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• W2923376335 endingPage "638" @default.
• W2923376335 startingPage "617" @default.
• W2923376335 abstract "Since the Hedgehog signaling pathway has been associated with cancer, it has emerged as a therapeutic target for cancer therapy. The main target among the key Hedgehog proteins is the GPCR-like Smo receptor. Therefore, some Smo antagonists that have entered clinical trials, including the US FDA-approved drugs vismodegib and sonidegib, to treat basal cell carcinoma and medulloblastoma. However, early resistance of these drugs has spawned the need to understand the molecular bases of this phenomena. We therefore reviewed details about Smo receptor structures and the best Smo antagonist chemical structures. In addition, we discussed strategies that should be considered to develop new, safer generations of Smo antagonists that avoid current clinical limitations." @default.
• W2923376335 created "2019-04-01" @default.
• W2923376335 creator A5030195026 @default.
• W2923376335 creator A5039270117 @default.
• W2923376335 creator A5077567118 @default.
• W2923376335 creator A5079415264 @default.
• W2923376335 date "2019-03-01" @default.
• W2923376335 modified "2023-10-03" @default.
• W2923376335 title "State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures" @default.
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