Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923610805> ?p ?o ?g. }
- W2923610805 endingPage "14" @default.
- W2923610805 startingPage "6" @default.
- W2923610805 abstract "Cardiovascular disease is the leading cause of diabetes-related morbidity and mortality. It is widely accepted that heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Mitochondria are the center of fatty acid (FA) and glucose metabolism and thus are likely to be impacted by impaired metabolism associated with diabetes. Although the cause of this increased heart failure risk is multifactorial, increasing evidence points toward a crucial role for cardiomyocyte mitochondria dysfunction. Altered energy metabolism, defects in mitochondrial dynamics, increased oxidative stress, impaired calcium (Ca2+) handling and mitochondria-induced cell death are observed in mitochondria of diabetic myocardium. In addition, mitochondrial dysfunction appears to contribute substantially to the origin of arrhythmias in diabetic hearts. The current review will describe these mitochondrial abnormalities in cardiomyocytes attempting to provide an overview of underlying mechanisms. Finally, we briefly discuss the potential link between mitochondrial malfunction and arrhythmogenesis." @default.
- W2923610805 created "2019-04-01" @default.
- W2923610805 creator A5025875546 @default.
- W2923610805 creator A5040398270 @default.
- W2923610805 creator A5083938851 @default.
- W2923610805 date "2019-05-01" @default.
- W2923610805 modified "2023-09-24" @default.
- W2923610805 title "Cardiomyocyte mitochondrial dysfunction in diabetes and its contribution in cardiac arrhythmogenesis" @default.
- W2923610805 cites W1021382246 @default.
- W2923610805 cites W1529592271 @default.
- W2923610805 cites W1562655948 @default.
- W2923610805 cites W1576822037 @default.
- W2923610805 cites W1760999968 @default.
- W2923610805 cites W1809230663 @default.
- W2923610805 cites W1882183807 @default.
- W2923610805 cites W1960357398 @default.
- W2923610805 cites W1968550558 @default.
- W2923610805 cites W1968878147 @default.
- W2923610805 cites W1970527212 @default.
- W2923610805 cites W1979127230 @default.
- W2923610805 cites W1986276307 @default.
- W2923610805 cites W1989101440 @default.
- W2923610805 cites W1992564227 @default.
- W2923610805 cites W1999391010 @default.
- W2923610805 cites W1999532278 @default.
- W2923610805 cites W2000325349 @default.
- W2923610805 cites W2006787533 @default.
- W2923610805 cites W2009278410 @default.
- W2923610805 cites W2011124873 @default.
- W2923610805 cites W2017163269 @default.
- W2923610805 cites W2018559323 @default.
- W2923610805 cites W2019480343 @default.
- W2923610805 cites W2021172172 @default.
- W2923610805 cites W2021871393 @default.
- W2923610805 cites W2024287748 @default.
- W2923610805 cites W2025144170 @default.
- W2923610805 cites W2034498301 @default.
- W2923610805 cites W2039440815 @default.
- W2923610805 cites W2054203136 @default.
- W2923610805 cites W2058763646 @default.
- W2923610805 cites W2070869619 @default.
- W2923610805 cites W2075957528 @default.
- W2923610805 cites W2077424966 @default.
- W2923610805 cites W2079462709 @default.
- W2923610805 cites W2080150505 @default.
- W2923610805 cites W2080659100 @default.
- W2923610805 cites W2081706292 @default.
- W2923610805 cites W2086246076 @default.
- W2923610805 cites W2092533923 @default.
- W2923610805 cites W2095063209 @default.
- W2923610805 cites W2095140180 @default.
- W2923610805 cites W2096317893 @default.
- W2923610805 cites W2096545094 @default.
- W2923610805 cites W2096772012 @default.
- W2923610805 cites W2097049860 @default.
- W2923610805 cites W2098328780 @default.
- W2923610805 cites W2098612318 @default.
- W2923610805 cites W2101840868 @default.
- W2923610805 cites W2103309568 @default.
- W2923610805 cites W2108113014 @default.
- W2923610805 cites W2111757377 @default.
- W2923610805 cites W2112637952 @default.
- W2923610805 cites W2114671826 @default.
- W2923610805 cites W2114944602 @default.
- W2923610805 cites W2115101707 @default.
- W2923610805 cites W2117931978 @default.
- W2923610805 cites W2120379299 @default.
- W2923610805 cites W2122167119 @default.
- W2923610805 cites W2123522154 @default.
- W2923610805 cites W2127321192 @default.
- W2923610805 cites W2128334241 @default.
- W2923610805 cites W2128473487 @default.
- W2923610805 cites W2128908058 @default.
- W2923610805 cites W2131666074 @default.
- W2923610805 cites W2133514174 @default.
- W2923610805 cites W2133992379 @default.
- W2923610805 cites W2135314348 @default.
- W2923610805 cites W2136937485 @default.
- W2923610805 cites W2137774140 @default.
- W2923610805 cites W2141188578 @default.
- W2923610805 cites W2143688500 @default.
- W2923610805 cites W2144766505 @default.
- W2923610805 cites W2149292131 @default.
- W2923610805 cites W2149566271 @default.
- W2923610805 cites W2150256240 @default.
- W2923610805 cites W2150820282 @default.
- W2923610805 cites W2152674951 @default.
- W2923610805 cites W2153042674 @default.
- W2923610805 cites W2153092921 @default.
- W2923610805 cites W2153866356 @default.
- W2923610805 cites W2154726349 @default.
- W2923610805 cites W2159262476 @default.
- W2923610805 cites W2160331251 @default.
- W2923610805 cites W2160448824 @default.
- W2923610805 cites W2160660790 @default.
- W2923610805 cites W2161291398 @default.
- W2923610805 cites W2161836085 @default.
- W2923610805 cites W2166432730 @default.