FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923644555> ?p ?o ?g. }

• W2923644555 abstract "Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by infections due to Trypanosoma brucei subspecies. In addition to the well-established environmental and behavioural risks of becoming infected, there is evidence for a genetic component to the response to trypanosome infection. We undertook a candidate gene case-control study to investigate genetic associations further.We genotyped one polymorphism in each of seven genes (IL1A, IL1RN, IL4RN, IL6, HP, HPR, and HLA-G) in 73 cases and 250 controls collected from 19 ethno-linguistic subgroups stratified into three major ethno-linguistic groups, 2 pooled ethno-linguistic groups and 11 ethno-linguistic subgroups from three Cameroonian HAT foci. The seven polymorphic loci tested consisted of three SNPs, three variable numbers of tandem repeat (VNTR) and one INDEL.We found that the genotype (TT) and minor allele (T) of IL1A gene as well as the genotype 1A3A of IL1RN were associated with an increased risk of getting Trypanosoma brucei gambiense and develop HAT when all data were analysed together and also when stratified by the three major ethno-linguistic groups, 2 pooled ethno-linguistic subgroups and 11 ethno-linguistic subgroups.This study revealed that one SNP rs1800794 of IL1A and one VNTR rs2234663 of IL1RN were associated with the increased risk to be infected by Trypanosoma brucei gambiense and develop sleeping sickness in southern Cameroon. The minor allele T and the genotype TT of SNP rs1800794 in IL1A as well as the genotype 1A3A of IL1RN rs2234663 VNTR seem to increase the risk of getting Trypanosoma brucei gambiense infections and develop sleeping sickness in southern Cameroon." @default.
• W2923644555 created "2019-04-01" @default.
• W2923644555 creator A5003822944 @default.
• W2923644555 creator A5014687627 @default.
• W2923644555 creator A5028041946 @default.
• W2923644555 creator A5034283362 @default.
• W2923644555 creator A5034389276 @default.
• W2923644555 creator A5038206688 @default.
• W2923644555 creator A5050244715 @default.
• W2923644555 creator A5068219851 @default.
• W2923644555 creator A5088635782 @default.
• W2923644555 creator A5089089482 @default.
• W2923644555 date "2019-03-25" @default.
• W2923644555 modified "2023-10-16" @default.
• W2923644555 title "Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon" @default.
• W2923644555 cites W17663478 @default.
• W2923644555 cites W180744667 @default.
• W2923644555 cites W1867338125 @default.
• W2923644555 cites W1926159205 @default.
• W2923644555 cites W1964612135 @default.
• W2923644555 cites W1967081185 @default.
• W2923644555 cites W1969564910 @default.
• W2923644555 cites W1970401043 @default.
• W2923644555 cites W1974251657 @default.
• W2923644555 cites W1977482627 @default.
• W2923644555 cites W1978733317 @default.
• W2923644555 cites W1980459782 @default.
• W2923644555 cites W1980815549 @default.
• W2923644555 cites W1986265706 @default.
• W2923644555 cites W1986644345 @default.
• W2923644555 cites W1990815225 @default.
• W2923644555 cites W1994553188 @default.
• W2923644555 cites W1996286571 @default.
• W2923644555 cites W2000726781 @default.
• W2923644555 cites W2000834459 @default.
• W2923644555 cites W2002806661 @default.
• W2923644555 cites W2005306209 @default.
• W2923644555 cites W2009144436 @default.
• W2923644555 cites W2012139771 @default.
• W2923644555 cites W2015831528 @default.
• W2923644555 cites W2017506148 @default.
• W2923644555 cites W2020461960 @default.
• W2923644555 cites W2026207762 @default.
• W2923644555 cites W2030923116 @default.
• W2923644555 cites W2038076957 @default.
• W2923644555 cites W2038992458 @default.
• W2923644555 cites W2043280443 @default.
• W2923644555 cites W2047231443 @default.
• W2923644555 cites W2049927826 @default.
• W2923644555 cites W2055347009 @default.
• W2923644555 cites W2062359839 @default.
• W2923644555 cites W2063765445 @default.
• W2923644555 cites W2066639195 @default.
• W2923644555 cites W2071131076 @default.
• W2923644555 cites W2079105132 @default.
• W2923644555 cites W2080420820 @default.
• W2923644555 cites W2088560448 @default.
• W2923644555 cites W2100303227 @default.
• W2923644555 cites W2102647767 @default.
• W2923644555 cites W2106616672 @default.
• W2923644555 cites W2110717939 @default.
• W2923644555 cites W2127597305 @default.
• W2923644555 cites W2127670550 @default.
• W2923644555 cites W2133901452 @default.
• W2923644555 cites W2134410122 @default.
• W2923644555 cites W2138355311 @default.
• W2923644555 cites W2140107100 @default.
• W2923644555 cites W2143112229 @default.
• W2923644555 cites W2151877638 @default.
• W2923644555 cites W2157163885 @default.
• W2923644555 cites W2161633633 @default.
• W2923644555 cites W2162098634 @default.
• W2923644555 cites W2182824092 @default.
• W2923644555 cites W236227114 @default.
• W2923644555 cites W2417953344 @default.
• W2923644555 cites W2440109215 @default.
• W2923644555 cites W2485772253 @default.
• W2923644555 cites W2619254835 @default.
• W2923644555 cites W2748096092 @default.
• W2923644555 cites W2765574764 @default.
• W2923644555 cites W2765598384 @default.
• W2923644555 cites W2785091500 @default.
• W2923644555 cites W2916998141 @default.
• W2923644555 cites W2950604450 @default.
• W2923644555 cites W4299703926 @default.
• W2923644555 doi "https://doi.org/10.1371/journal.pntd.0007283" @default.
• W2923644555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6448947" @default.
• W2923644555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30908482" @default.
• W2923644555 hasPublicationYear "2019" @default.
• W2923644555 type Work @default.
• W2923644555 sameAs 2923644555 @default.
• W2923644555 citedByCount "1" @default.
• W2923644555 countsByYear W29236445552020 @default.
• W2923644555 crossrefType "journal-article" @default.
• W2923644555 hasAuthorship W2923644555A5003822944 @default.
• W2923644555 hasAuthorship W2923644555A5014687627 @default.
• W2923644555 hasAuthorship W2923644555A5028041946 @default.
• W2923644555 hasAuthorship W2923644555A5034283362 @default.
• W2923644555 hasAuthorship W2923644555A5034389276 @default.
• W2923644555 hasAuthorship W2923644555A5038206688 @default.

• next