FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923645225> ?p ?o ?g. }

• W2923645225 endingPage "13" @default.
• W2923645225 startingPage "1" @default.
• W2923645225 abstract "To investigate the mechanism of a Bushen-Jianpi decoction (BSJPD) in liver cancer (LC) treatment, we analyzed clinical therapy data, conducted network pharmacology analysis, and performed pharmacological experimental verification in vitro and in vivo. The univariate analysis of clinical therapy showed that the BSJPD was protective factor (p < 0.05). The network pharmacology analysis showed that 9 compounds were important nodes of BSJPD-LC therapy network. In experimental verification, the rate of apoptosis increased in the liver tumors of mice treated with the BSJPD (p < 0.05); drug serum with 20 % BSJPD inhibited cell viability (p < 0.05) and reduced the expression of PI3K, the Bcl-xL/BAD ratio, and the levels of p53 and p-Akt in HepG2 cells. Moreover, licochalcone A, alisol B, and hederagenin inhibited cell viability (p < 0.05), induced cell apoptosis (p < 0.01), reduced p-Akt levels, and increased cleaved-CASP3 (p < 0.05) and p53 expression levels in HepG2 cells. These data suggest that the BSJPD prolongs the survival of LC patients and induces apoptosis and that it may be associated with the regulation of PI3K, Akt, p53, CASP3, and Bcl-xL/BAD expression." @default.
• W2923645225 created "2019-04-01" @default.
• W2923645225 creator A5012760955 @default.
• W2923645225 creator A5031017817 @default.
• W2923645225 creator A5041247351 @default.
• W2923645225 creator A5062687402 @default.
• W2923645225 creator A5066801001 @default.
• W2923645225 creator A5073215699 @default.
• W2923645225 creator A5074544818 @default.
• W2923645225 creator A5078197216 @default.
• W2923645225 creator A5089001993 @default.
• W2923645225 creator A5089079624 @default.
• W2923645225 date "2019-03-19" @default.
• W2923645225 modified "2023-10-16" @default.
• W2923645225 title "Network Pharmacology-Based Study on the Mechanism of Bushen-Jianpi Decoction in Liver Cancer Treatment" @default.
• W2923645225 cites W1570689006 @default.
• W2923645225 cites W1879762752 @default.
• W2923645225 cites W1974245465 @default.
• W2923645225 cites W1997857177 @default.
• W2923645225 cites W1998790582 @default.
• W2923645225 cites W2001108463 @default.
• W2923645225 cites W2002716364 @default.
• W2923645225 cites W2008141370 @default.
• W2923645225 cites W2011817914 @default.
• W2923645225 cites W2012141576 @default.
• W2923645225 cites W2019513836 @default.
• W2923645225 cites W2024215200 @default.
• W2923645225 cites W2025687548 @default.
• W2923645225 cites W2039930764 @default.
• W2923645225 cites W2059008385 @default.
• W2923645225 cites W2065855687 @default.
• W2923645225 cites W2071524470 @default.
• W2923645225 cites W2072653158 @default.
• W2923645225 cites W2077534147 @default.
• W2923645225 cites W2081980323 @default.
• W2923645225 cites W2085387078 @default.
• W2923645225 cites W2088886967 @default.
• W2923645225 cites W2094599199 @default.
• W2923645225 cites W2131753291 @default.
• W2923645225 cites W2135617615 @default.
• W2923645225 cites W2143728413 @default.
• W2923645225 cites W2149818581 @default.
• W2923645225 cites W2154799239 @default.
• W2923645225 cites W2167536008 @default.
• W2923645225 cites W2168630917 @default.
• W2923645225 cites W2171541660 @default.
• W2923645225 cites W2276650051 @default.
• W2923645225 cites W2321368314 @default.
• W2923645225 cites W2337446862 @default.
• W2923645225 cites W2345615963 @default.
• W2923645225 cites W2359099482 @default.
• W2923645225 cites W2403911643 @default.
• W2923645225 cites W2466068552 @default.
• W2923645225 cites W2588666440 @default.
• W2923645225 cites W2597922397 @default.
• W2923645225 cites W2610550910 @default.
• W2923645225 cites W2618504445 @default.
• W2923645225 cites W2744564915 @default.
• W2923645225 cites W2762736025 @default.
• W2923645225 cites W2769046912 @default.
• W2923645225 cites W2771828541 @default.
• W2923645225 cites W2772575815 @default.
• W2923645225 cites W2774137205 @default.
• W2923645225 cites W2801943992 @default.
• W2923645225 doi "https://doi.org/10.1155/2019/3242989" @default.
• W2923645225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6444272" @default.
• W2923645225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31015849" @default.
• W2923645225 hasPublicationYear "2019" @default.
• W2923645225 type Work @default.
• W2923645225 sameAs 2923645225 @default.
• W2923645225 citedByCount "9" @default.
• W2923645225 countsByYear W29236452252020 @default.
• W2923645225 countsByYear W29236452252021 @default.
• W2923645225 countsByYear W29236452252022 @default.
• W2923645225 countsByYear W29236452252023 @default.
• W2923645225 crossrefType "journal-article" @default.
• W2923645225 hasAuthorship W2923645225A5012760955 @default.
• W2923645225 hasAuthorship W2923645225A5031017817 @default.
• W2923645225 hasAuthorship W2923645225A5041247351 @default.
• W2923645225 hasAuthorship W2923645225A5062687402 @default.
• W2923645225 hasAuthorship W2923645225A5066801001 @default.
• W2923645225 hasAuthorship W2923645225A5073215699 @default.
• W2923645225 hasAuthorship W2923645225A5074544818 @default.
• W2923645225 hasAuthorship W2923645225A5078197216 @default.
• W2923645225 hasAuthorship W2923645225A5089001993 @default.
• W2923645225 hasAuthorship W2923645225A5089079624 @default.
• W2923645225 hasBestOaLocation W29236452251 @default.
• W2923645225 hasConcept C126322002 @default.
• W2923645225 hasConcept C150903083 @default.
• W2923645225 hasConcept C185592680 @default.
• W2923645225 hasConcept C190283241 @default.
• W2923645225 hasConcept C190409667 @default.
• W2923645225 hasConcept C207001950 @default.
• W2923645225 hasConcept C2776999253 @default.
• W2923645225 hasConcept C502942594 @default.
• W2923645225 hasConcept C53227056 @default.
• W2923645225 hasConcept C55493867 @default.
• W2923645225 hasConcept C71924100 @default.

• next