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- W2923646939 abstract "In this report, eight antihypertensive peptides were isolated from protein hydrolysate of Antarctic krill (Euphausia superba) using ultrafiltration and chromatography consecutively, and their sequences were identified as Trp-Phe, Tyr-Arg-Lys-Glu-Arg, Tyr-Arg-Lys, Val-Asp, Tyr-Lys-Asp, Phe-Gln-Lys, Phe-Ala-Ser, and Phe-Arg-Lys-Glu. The IC50 values of Trp-Phe (0.32 ± 0.05 mg/mL) and Phe-Ala-Ser (0.15 ± 0.02 mg/mL) on ACE inhibitory activity were significantly (p ≤ .05) lower than those of the other six peptides. Furthermore, Trp-Phe, Tyr-Arg-Lys, Phe-Gln-Lys, and Phe-Ala-Ser did not only increase the nitric oxide (NO) concentration and decreased the content of endothelin-1 (ET-1) in the medium of human umbilical vein endothelial cells (HUVECs) in a dose-dependent manner after 24 h, but also significantly reversed the decreased production of NO in the presence of 0.5 μM norepinephrine and the effect of NE on ET-1 production. These results indicate that the isolated antihypertensive peptides can correct the endothelial cell dysfunction induced by norepinephrine." @default.
- W2923646939 created "2019-04-01" @default.
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- W2923646939 date "2019-07-01" @default.
- W2923646939 modified "2023-10-16" @default.
- W2923646939 title "Eight antihypertensive peptides from the protein hydrolysate of Antarctic krill (Euphausia superba): Isolation, identification, and activity evaluation on human umbilical vein endothelial cells (HUVECs)" @default.
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- W2923646939 doi "https://doi.org/10.1016/j.foodres.2019.03.035" @default.
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