Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923683328> ?p ?o ?g. }
- W2923683328 endingPage "1180" @default.
- W2923683328 startingPage "1180" @default.
- W2923683328 abstract "2'-O-Methylribo phosphorothioate oligonucleotides incorporating cyclopalladated benzylamine conjugate groups at their 5'-termini have been prepared and their ability to hybridize with a designated target sequence was assessed by conventional UV melting experiments. The oligonucleotides were further examined in splice-switching experiments in human cervical cancer (HeLa Luc/705), human liver (HuH7_705), and human osteosarcoma (U-2 OS_705) reporter cell lines. Melting temperatures of duplexes formed by the modified oligonucleotides were approximately 5 °C lower than melting temperatures of the respective unmodified duplexes. The cyclopalladated oligonucleotides functioned as splice-correcting agents in the HeLa Luc/705 cell line somewhat more efficiently than their unmodified counterparts. Furthermore, the introduction of this chemical modification did not induce toxicity in cells. These results demonstrate the feasibility of using covalently metalated oligonucleotides as therapeutic agents." @default.
- W2923683328 created "2019-04-01" @default.
- W2923683328 creator A5026544069 @default.
- W2923683328 creator A5036357426 @default.
- W2923683328 creator A5042257883 @default.
- W2923683328 creator A5064738558 @default.
- W2923683328 creator A5067890737 @default.
- W2923683328 creator A5072052699 @default.
- W2923683328 date "2019-03-26" @default.
- W2923683328 modified "2023-10-12" @default.
- W2923683328 title "Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents" @default.
- W2923683328 cites W1526905286 @default.
- W2923683328 cites W169228635 @default.
- W2923683328 cites W1952915322 @default.
- W2923683328 cites W1966868778 @default.
- W2923683328 cites W1988619957 @default.
- W2923683328 cites W2001138065 @default.
- W2923683328 cites W2008324345 @default.
- W2923683328 cites W2015551798 @default.
- W2923683328 cites W2031252637 @default.
- W2923683328 cites W2040135588 @default.
- W2923683328 cites W2040743013 @default.
- W2923683328 cites W2045347539 @default.
- W2923683328 cites W2049200073 @default.
- W2923683328 cites W2051192216 @default.
- W2923683328 cites W2051997653 @default.
- W2923683328 cites W2066839011 @default.
- W2923683328 cites W2069977478 @default.
- W2923683328 cites W2103339395 @default.
- W2923683328 cites W2119171285 @default.
- W2923683328 cites W2122290210 @default.
- W2923683328 cites W2135566609 @default.
- W2923683328 cites W2160859867 @default.
- W2923683328 cites W2162215932 @default.
- W2923683328 cites W2284974718 @default.
- W2923683328 cites W2319947215 @default.
- W2923683328 cites W2411634967 @default.
- W2923683328 cites W2443532808 @default.
- W2923683328 cites W2513989408 @default.
- W2923683328 cites W2519453322 @default.
- W2923683328 cites W2555443028 @default.
- W2923683328 cites W2587985131 @default.
- W2923683328 cites W2592524531 @default.
- W2923683328 cites W2594574412 @default.
- W2923683328 cites W2624827575 @default.
- W2923683328 cites W2749106357 @default.
- W2923683328 cites W2771932281 @default.
- W2923683328 cites W2774034164 @default.
- W2923683328 cites W2793471865 @default.
- W2923683328 cites W2803997860 @default.
- W2923683328 cites W2804619194 @default.
- W2923683328 cites W2891651899 @default.
- W2923683328 cites W2895155188 @default.
- W2923683328 cites W4237809595 @default.
- W2923683328 cites W54226581 @default.
- W2923683328 cites W2014597561 @default.
- W2923683328 doi "https://doi.org/10.3390/molecules24061180" @default.
- W2923683328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6470670" @default.
- W2923683328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30917503" @default.
- W2923683328 hasPublicationYear "2019" @default.
- W2923683328 type Work @default.
- W2923683328 sameAs 2923683328 @default.
- W2923683328 citedByCount "9" @default.
- W2923683328 countsByYear W29236833282019 @default.
- W2923683328 countsByYear W29236833282020 @default.
- W2923683328 countsByYear W29236833282021 @default.
- W2923683328 countsByYear W29236833282022 @default.
- W2923683328 crossrefType "journal-article" @default.
- W2923683328 hasAuthorship W2923683328A5026544069 @default.
- W2923683328 hasAuthorship W2923683328A5036357426 @default.
- W2923683328 hasAuthorship W2923683328A5042257883 @default.
- W2923683328 hasAuthorship W2923683328A5064738558 @default.
- W2923683328 hasAuthorship W2923683328A5067890737 @default.
- W2923683328 hasAuthorship W2923683328A5072052699 @default.
- W2923683328 hasBestOaLocation W29236833281 @default.
- W2923683328 hasConcept C104317684 @default.
- W2923683328 hasConcept C129312508 @default.
- W2923683328 hasConcept C134306372 @default.
- W2923683328 hasConcept C1491633281 @default.
- W2923683328 hasConcept C153911025 @default.
- W2923683328 hasConcept C178790620 @default.
- W2923683328 hasConcept C185592680 @default.
- W2923683328 hasConcept C197336794 @default.
- W2923683328 hasConcept C21951064 @default.
- W2923683328 hasConcept C2776276205 @default.
- W2923683328 hasConcept C2777366897 @default.
- W2923683328 hasConcept C2780989783 @default.
- W2923683328 hasConcept C33923547 @default.
- W2923683328 hasConcept C552990157 @default.
- W2923683328 hasConcept C55493867 @default.
- W2923683328 hasConcept C71240020 @default.
- W2923683328 hasConcept C86803240 @default.
- W2923683328 hasConceptScore W2923683328C104317684 @default.
- W2923683328 hasConceptScore W2923683328C129312508 @default.
- W2923683328 hasConceptScore W2923683328C134306372 @default.
- W2923683328 hasConceptScore W2923683328C1491633281 @default.
- W2923683328 hasConceptScore W2923683328C153911025 @default.
- W2923683328 hasConceptScore W2923683328C178790620 @default.