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• W2923687617 abstract "A candidate inhibitor of filamentous fungal protein kinase C (PKC), Z-705, was identified by in silico screening. A screening system to evaluate the effects of fungal PKC inhibitors was constructed in Saccharomyces cerevisiae . Using this system, we found that Z-705 is highly selective for filamentous fungal PKC in comparison with S. cerevisiae PKC. Analysis of the AGS1 mRNA level, which is regulated by Mps1p mitogen-activated protein kinase (MAPK) via PKC, in the rice blast fungus Magnaporthe grisea revealed that Z-705 had a PKC inhibitory effect comparable to that of staurosporine. Micafungin induced hyphal melanization in M. grisea , and this melanization, which is required for pathogenicity of M. grisea , was inhibited by PKC inhibition by both Z-705 and staurosporine. The mRNA levels of 4HNR , 3HNR , and SCD1 , which are essential for melanization in M. grisea , were suppressed by both PKC inhibitors." @default.
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• W2923687617 date "2019-05-15" @default.
• W2923687617 modified "2023-10-02" @default.
• W2923687617 title "Novel Antifungal Compound Z-705 Specifically Inhibits Protein Kinase C of Filamentous Fungi" @default.
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• W2923687617 doi "https://doi.org/10.1128/aem.02923-18" @default.
• W2923687617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6498157" @default.
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