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- W2923707162 abstract "Abstract:Immunosuppressive drugs are now unavoidably used after the transplantation of liver, heart and bone marrow, as well as in certain autoimmune diseases. Among these agents, Cyclosporine-A (CyA) is one of the most effective immunosuppressants which is widely used. But as any other immunosuppressive agent, the use of CyA is not without harmful side effects. Neurotoxic, nephrotoxic and hepatotoxic complications may be seen in patients treated with CyA. For the first time Borel from Sandoz research center (Switzerland) showed that the metabolite of a fungus named Tolypcladium inflatum gams, has a suppressive effect on immune system. Thirty intermediate products of CyA metabolic pathway have been know so far and some studies have demonstrated the properties of a limited number of these products (M1, M8, M17, M21). Pharmacodynamic studies on CyA have revealed that the immunosuppressive effect of this drug is mainly achievable by its activity on T-lymphocyte. In fact, CyA inhibits the gene transcription in T-lymphocytes which results in lesser or no production of antigen-antibody complex. Since the administered therapeutic dose of drug is a variable of many factors such as the type of transplanted organ, physiologic state of the patient, bioavailability and the treatment protocol and on the other hand, CyA has some destructive side effects on the other body organs, therefore determination of the effective therapeutic dose of CyA, and frequent measurement of CyA and its metabolites concentrations in blood is a necessity.Keywords: Cyclosporine-A, Immunosuppressive drug, Organ transplantation" @default.
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- W2923707162 title "The significance of determining the therapeutic dose of Cyclosporine-A in patients undergoing organ transplantation" @default.
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