FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923710107> ?p ?o ?g. }

• W2923710107 abstract "Abstract Background Synthetic cannabinoids are a commonly used class of recreational drugs that can have significant adverse effects. There have been sporadic reports of co-consumption of illicit drugs with rodenticides such as warfarin and brodifacoum (BFC) over the past 20 years but recently, hundreds of people have been reported to have been poisoned with a mixture of synthetic cannabinoids and BFC. We have sought to establish whether BFC directly affects cannabinoid receptors, or their activation by the synthetic cannabinoid CP55940 or the phytocannabinoid Δ 9 -tetrahydrocannabinol (Δ 9 -THC). Methods The effects of BFC on the hyperpolarization of wild type AtT20 cells, or AtT20 cells stably expressing human CB 1 - and CB 2 -mediated receptors, were studied using a fluorescent assay of membrane potential. The effects of BFC on CB 1 and CB 2 mediated inhibition of forskolin-stimulated adenylyl cyclase (AC) activation was measured using a BRET assay of cAMP levels in HEK 293 cells stably expressing human CB 1 and CB 2 . Results BFC did not activate CB 1 or CB 2 receptors, or affect the hyperpolarization of wild type AtT20 cells produced by somatostatin. BFC (10 µ M) did not affect the hyperpolarization of AtT20-CB 1 or AtT20-CB 2 cells produced by CP55940 or Δ 9 -THC. BFC (1 µ M) did not affect the inhibition of forskolin-stimulated AC activity by CP55940 in HEK 293 cells expressing CB 1 or CB 2 . BFC (1 µ M) also failed to affect the desensitization of CB 1 and CB 2 signalling produced by prolonged (30 min) application of CP55940 or Δ 9 -THC to AtT20 cells. Discussion BFC is not a cannabinoid receptor agonist, and appeared not to affect cannabinoid receptor activation. Our data suggests there is no pharmacodynamic rationale for mixing BFC with synthetic cannabinoids, however, it does not speak to whether BFC may affect synthetic cannabinoid metabolism or biodistribution. The reasons underlying the mixing of BFC with synthetic cannabinoids are unknown, and it remains to be established whether the “contamination” was deliberate or accidental. However, the consequences for people who ingested the mixture were often serious, and sometimes fatal, but this seems unlikely to be due to BFC action at cannabinoid receptors." @default.
• W2923710107 created "2019-04-01" @default.
• W2923710107 creator A5010714266 @default.
• W2923710107 creator A5045230401 @default.
• W2923710107 creator A5053915349 @default.
• W2923710107 creator A5075525937 @default.
• W2923710107 date "2019-03-27" @default.
• W2923710107 modified "2023-09-28" @default.
• W2923710107 title "Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells" @default.
• W2923710107 cites W1492703982 @default.
• W2923710107 cites W1670633125 @default.
• W2923710107 cites W1890620814 @default.
• W2923710107 cites W1975214876 @default.
• W2923710107 cites W1991403136 @default.
• W2923710107 cites W2028491124 @default.
• W2923710107 cites W2035929830 @default.
• W2923710107 cites W2038784126 @default.
• W2923710107 cites W2076456625 @default.
• W2923710107 cites W2113689031 @default.
• W2923710107 cites W2149845270 @default.
• W2923710107 cites W2153539777 @default.
• W2923710107 cites W2294124386 @default.
• W2923710107 cites W2326889891 @default.
• W2923710107 cites W2344345617 @default.
• W2923710107 cites W2470236573 @default.
• W2923710107 cites W2613465380 @default.
• W2923710107 cites W2620628134 @default.
• W2923710107 cites W2626033047 @default.
• W2923710107 cites W2726882144 @default.
• W2923710107 cites W2807196896 @default.
• W2923710107 cites W2869712208 @default.
• W2923710107 cites W2883006223 @default.
• W2923710107 cites W2888896676 @default.
• W2923710107 cites W2892710743 @default.
• W2923710107 cites W2894118435 @default.
• W2923710107 cites W2911663770 @default.
• W2923710107 doi "https://doi.org/10.1101/589341" @default.
• W2923710107 hasPublicationYear "2019" @default.
• W2923710107 type Work @default.
• W2923710107 sameAs 2923710107 @default.
• W2923710107 citedByCount "1" @default.
• W2923710107 countsByYear W29237101072019 @default.
• W2923710107 crossrefType "posted-content" @default.
• W2923710107 hasAuthorship W2923710107A5010714266 @default.
• W2923710107 hasAuthorship W2923710107A5045230401 @default.
• W2923710107 hasAuthorship W2923710107A5053915349 @default.
• W2923710107 hasAuthorship W2923710107A5075525937 @default.
• W2923710107 hasBestOaLocation W29237101071 @default.
• W2923710107 hasConcept C131453863 @default.
• W2923710107 hasConcept C148001335 @default.
• W2923710107 hasConcept C170493617 @default.
• W2923710107 hasConcept C174510640 @default.
• W2923710107 hasConcept C185592680 @default.
• W2923710107 hasConcept C2778938600 @default.
• W2923710107 hasConcept C2779178603 @default.
• W2923710107 hasConcept C2780871563 @default.
• W2923710107 hasConcept C55493867 @default.
• W2923710107 hasConcept C66974803 @default.
• W2923710107 hasConcept C71240020 @default.
• W2923710107 hasConcept C86803240 @default.
• W2923710107 hasConcept C93248783 @default.
• W2923710107 hasConcept C98274493 @default.
• W2923710107 hasConceptScore W2923710107C131453863 @default.
• W2923710107 hasConceptScore W2923710107C148001335 @default.
• W2923710107 hasConceptScore W2923710107C170493617 @default.
• W2923710107 hasConceptScore W2923710107C174510640 @default.
• W2923710107 hasConceptScore W2923710107C185592680 @default.
• W2923710107 hasConceptScore W2923710107C2778938600 @default.
• W2923710107 hasConceptScore W2923710107C2779178603 @default.
• W2923710107 hasConceptScore W2923710107C2780871563 @default.
• W2923710107 hasConceptScore W2923710107C55493867 @default.
• W2923710107 hasConceptScore W2923710107C66974803 @default.
• W2923710107 hasConceptScore W2923710107C71240020 @default.
• W2923710107 hasConceptScore W2923710107C86803240 @default.
• W2923710107 hasConceptScore W2923710107C93248783 @default.
• W2923710107 hasConceptScore W2923710107C98274493 @default.
• W2923710107 hasLocation W29237101071 @default.
• W2923710107 hasLocation W29237101072 @default.
• W2923710107 hasOpenAccess W2923710107 @default.
• W2923710107 hasPrimaryLocation W29237101071 @default.
• W2923710107 hasRelatedWork W1486010290 @default.
• W2923710107 hasRelatedWork W1971653584 @default.
• W2923710107 hasRelatedWork W1984286105 @default.
• W2923710107 hasRelatedWork W1990893297 @default.
• W2923710107 hasRelatedWork W2004634500 @default.
• W2923710107 hasRelatedWork W2006755079 @default.
• W2923710107 hasRelatedWork W2048306858 @default.
• W2923710107 hasRelatedWork W2067312146 @default.
• W2923710107 hasRelatedWork W2068455138 @default.
• W2923710107 hasRelatedWork W2071116267 @default.
• W2923710107 hasRelatedWork W2075171154 @default.
• W2923710107 hasRelatedWork W2082237701 @default.
• W2923710107 hasRelatedWork W2153644263 @default.
• W2923710107 hasRelatedWork W2507965617 @default.
• W2923710107 hasRelatedWork W2558259824 @default.
• W2923710107 hasRelatedWork W2590381008 @default.
• W2923710107 hasRelatedWork W2895018796 @default.
• W2923710107 hasRelatedWork W2920133387 @default.
• W2923710107 hasRelatedWork W2975179097 @default.
• W2923710107 hasRelatedWork W2188208965 @default.

• next