FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923742693> ?p ?o ?g. }

• W2923742693 abstract "Abstract Host-directed therapeutics are a promising anti-infective strategy against intracellular bacterial pathogens. Repurposing host-targeted drugs approved by the FDA in the US, the MHRA in the UK and/or regulatory equivalents in other countries, is particularly interesting because these drugs are commercially available, safe doses are documented and they have been already approved for other clinical purposes. In this study, we aimed to identify novel therapies against intracellular Staphylococcus aureus , an opportunistic pathogen that is able to exploit host molecular and metabolic pathways to support its own intracellular survival. We screened 133 host-targeting drugs and found three host-directed tyrosine kinase inhibitors (Ibrutinib, Dasatinib and Crizotinib) that substantially impaired intracellular bacterial survival. We found that Ibrutinib significantly increased host cell viability after S. aureus infection via inhibition of cell invasion and intracellular bacterial proliferation. Using phosphoproteomics data, we propose a putative mechanism of action of Ibrutinib involving several host factors, including EPHA2, C-JUN and NWASP. We confirmed the importance of EPHA2 for staphylococcal infection in an EPHA2 -knock-out cell line. Our study serves as an important example of feasibility for identifying host-directed therapeutics as candidates for repurposing." @default.
• W2923742693 created "2019-04-01" @default.
• W2923742693 creator A5014180570 @default.
• W2923742693 creator A5015127274 @default.
• W2923742693 creator A5021400498 @default.
• W2923742693 creator A5028795183 @default.
• W2923742693 creator A5035774522 @default.
• W2923742693 creator A5049370608 @default.
• W2923742693 creator A5056831712 @default.
• W2923742693 creator A5058550136 @default.
• W2923742693 creator A5078545135 @default.
• W2923742693 creator A5083109741 @default.
• W2923742693 date "2019-03-19" @default.
• W2923742693 modified "2023-10-01" @default.
• W2923742693 title "Host-directed kinase inhibitors act as novel therapies against intracellular Staphylococcus aureus" @default.
• W2923742693 cites W1562501682 @default.
• W2923742693 cites W1830209188 @default.
• W2923742693 cites W1831717060 @default.
• W2923742693 cites W1893306363 @default.
• W2923742693 cites W1915856409 @default.
• W2923742693 cites W1948355459 @default.
• W2923742693 cites W1965680643 @default.
• W2923742693 cites W1985318253 @default.
• W2923742693 cites W1986930831 @default.
• W2923742693 cites W1993345471 @default.
• W2923742693 cites W2000590947 @default.
• W2923742693 cites W2011681488 @default.
• W2923742693 cites W2018872127 @default.
• W2923742693 cites W2021299992 @default.
• W2923742693 cites W2021856025 @default.
• W2923742693 cites W2027837678 @default.
• W2923742693 cites W2036681019 @default.
• W2923742693 cites W2052313855 @default.
• W2923742693 cites W2053170600 @default.
• W2923742693 cites W2056586891 @default.
• W2923742693 cites W2063527102 @default.
• W2923742693 cites W2073599411 @default.
• W2923742693 cites W2073831807 @default.
• W2923742693 cites W2082918574 @default.
• W2923742693 cites W2083492619 @default.
• W2923742693 cites W2094830630 @default.
• W2923742693 cites W2096314274 @default.
• W2923742693 cites W2100097883 @default.
• W2923742693 cites W2100438695 @default.
• W2923742693 cites W2103820395 @default.
• W2923742693 cites W2109985686 @default.
• W2923742693 cites W2114896344 @default.
• W2923742693 cites W2115875812 @default.
• W2923742693 cites W2122826545 @default.
• W2923742693 cites W2126467473 @default.
• W2923742693 cites W2127545461 @default.
• W2923742693 cites W2128166172 @default.
• W2923742693 cites W2142474397 @default.
• W2923742693 cites W2143119706 @default.
• W2923742693 cites W2145109145 @default.
• W2923742693 cites W2147545245 @default.
• W2923742693 cites W2150893994 @default.
• W2923742693 cites W2151663481 @default.
• W2923742693 cites W2155147216 @default.
• W2923742693 cites W2155957426 @default.
• W2923742693 cites W2158217645 @default.
• W2923742693 cites W2167200907 @default.
• W2923742693 cites W2238393175 @default.
• W2923742693 cites W2303243520 @default.
• W2923742693 cites W2327287238 @default.
• W2923742693 cites W2330028620 @default.
• W2923742693 cites W2336786371 @default.
• W2923742693 cites W2563711991 @default.
• W2923742693 cites W2581426267 @default.
• W2923742693 cites W2757983152 @default.
• W2923742693 cites W2780449395 @default.
• W2923742693 cites W2786572209 @default.
• W2923742693 cites W2792689110 @default.
• W2923742693 cites W2794351815 @default.
• W2923742693 cites W2887404222 @default.
• W2923742693 doi "https://doi.org/10.1038/s41598-019-41260-8" @default.
• W2923742693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6425000" @default.
• W2923742693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30890742" @default.
• W2923742693 hasPublicationYear "2019" @default.
• W2923742693 type Work @default.
• W2923742693 sameAs 2923742693 @default.
• W2923742693 citedByCount "18" @default.
• W2923742693 countsByYear W29237426932019 @default.
• W2923742693 countsByYear W29237426932020 @default.
• W2923742693 countsByYear W29237426932021 @default.
• W2923742693 countsByYear W29237426932022 @default.
• W2923742693 countsByYear W29237426932023 @default.
• W2923742693 crossrefType "journal-article" @default.
• W2923742693 hasAuthorship W2923742693A5014180570 @default.
• W2923742693 hasAuthorship W2923742693A5015127274 @default.
• W2923742693 hasAuthorship W2923742693A5021400498 @default.
• W2923742693 hasAuthorship W2923742693A5028795183 @default.
• W2923742693 hasAuthorship W2923742693A5035774522 @default.
• W2923742693 hasAuthorship W2923742693A5049370608 @default.
• W2923742693 hasAuthorship W2923742693A5056831712 @default.
• W2923742693 hasAuthorship W2923742693A5058550136 @default.
• W2923742693 hasAuthorship W2923742693A5078545135 @default.
• W2923742693 hasAuthorship W2923742693A5083109741 @default.
• W2923742693 hasBestOaLocation W29237426931 @default.
• W2923742693 hasConcept C103637391 @default.

• next