FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923756047> ?p ?o ?g. }

• W2923756047 endingPage "914" @default.
• W2923756047 startingPage "899" @default.
• W2923756047 abstract "Whether hormone replacement therapy has beneficial metabolic effects in postmenopausal women remains controversial because of between-study differences in menopausal duration, estrogen formulations, and diet. Additionally, animal studies have not reflected the typical human obesogenic, Western-style diet (WSD). In this study, we determined the effects of immediate 17β-estradiol (ImE) or delayed 17β-estradiol treatment on weight and metabolism parameters in old ovo-hysterectomized rhesus macaques consuming a WSD over a 30-month period. The placebo and ImE groups exhibited progressive gains in weight and fat mass, which ImE initially attenuated but did not prevent. Progression of insulin resistance (IR) was lessened by ImE compared with placebo under both fasting and IV glucose–stimulated conditions, plateauing in all groups between 24 and 30 months. Consequently, relative euglycemia was maintained through lower stimulated insulin levels with ImE than with placebo. Bone mineral density decreased in the placebo group but was maintained in the ImE group, whereas bone mineral content was unaffected by placebo and increased with ImE. Daily activity was reduced while macaques consumed a WSD and was not affected by ImE. Over time, total cholesterol, triglyceride, very-low-density cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and IL-8 levels increased or trended upward in all animals, with only the change in HDL-C affected by ImE. Delayed estrogen treatment (months 24 to 30) had no significant impact on body composition or glucometabolic parameters. In summary, detrimental WSD-induced changes in body composition and metabolism were only temporarily ameliorated by ImE, with the important exception of glucose homeostasis, which benefited from E replacement even as body composition worsened." @default.
• W2923756047 created "2019-04-01" @default.
• W2923756047 creator A5004181866 @default.
• W2923756047 creator A5005189935 @default.
• W2923756047 creator A5054652468 @default.
• W2923756047 creator A5055662535 @default.
• W2923756047 creator A5056376384 @default.
• W2923756047 date "2019-02-07" @default.
• W2923756047 modified "2023-10-14" @default.
• W2923756047 title "Estradiol Replacement Timing and Obesogenic Diet Effects on Body Composition and Metabolism in Postmenopausal Macaques" @default.
• W2923756047 cites W1738368558 @default.
• W2923756047 cites W1772008586 @default.
• W2923756047 cites W1851403026 @default.
• W2923756047 cites W1872729885 @default.
• W2923756047 cites W1964457494 @default.
• W2923756047 cites W1970918827 @default.
• W2923756047 cites W1971867327 @default.
• W2923756047 cites W1977040679 @default.
• W2923756047 cites W1983331304 @default.
• W2923756047 cites W1993320216 @default.
• W2923756047 cites W2016515302 @default.
• W2923756047 cites W2018510008 @default.
• W2923756047 cites W2021344960 @default.
• W2923756047 cites W2022727635 @default.
• W2923756047 cites W2032422942 @default.
• W2923756047 cites W2035482833 @default.
• W2923756047 cites W2047108227 @default.
• W2923756047 cites W2062615522 @default.
• W2923756047 cites W2064176291 @default.
• W2923756047 cites W2066403330 @default.
• W2923756047 cites W2070095465 @default.
• W2923756047 cites W2072821667 @default.
• W2923756047 cites W2076517403 @default.
• W2923756047 cites W2076975509 @default.
• W2923756047 cites W2082130856 @default.
• W2923756047 cites W2086279120 @default.
• W2923756047 cites W2092962639 @default.
• W2923756047 cites W2094219322 @default.
• W2923756047 cites W2096913799 @default.
• W2923756047 cites W2097776282 @default.
• W2923756047 cites W2102826076 @default.
• W2923756047 cites W2111534662 @default.
• W2923756047 cites W2116456394 @default.
• W2923756047 cites W2116474059 @default.
• W2923756047 cites W2124569831 @default.
• W2923756047 cites W2139323290 @default.
• W2923756047 cites W2146136609 @default.
• W2923756047 cites W2161591122 @default.
• W2923756047 cites W2166988806 @default.
• W2923756047 cites W2167727277 @default.
• W2923756047 cites W2326263541 @default.
• W2923756047 cites W2341244791 @default.
• W2923756047 cites W2415921346 @default.
• W2923756047 cites W2465155672 @default.
• W2923756047 cites W2546761941 @default.
• W2923756047 cites W2606520020 @default.
• W2923756047 cites W2626981280 @default.
• W2923756047 cites W2767921395 @default.
• W2923756047 cites W2808711495 @default.
• W2923756047 cites W2892674731 @default.
• W2923756047 cites W2903378764 @default.
• W2923756047 cites W4248186749 @default.
• W2923756047 doi "https://doi.org/10.1210/en.2018-00884" @default.
• W2923756047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6435013" @default.
• W2923756047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30753523" @default.
• W2923756047 hasPublicationYear "2019" @default.
• W2923756047 type Work @default.
• W2923756047 sameAs 2923756047 @default.
• W2923756047 citedByCount "8" @default.
• W2923756047 countsByYear W29237560472019 @default.
• W2923756047 countsByYear W29237560472020 @default.
• W2923756047 countsByYear W29237560472021 @default.
• W2923756047 countsByYear W29237560472022 @default.
• W2923756047 countsByYear W29237560472023 @default.
• W2923756047 crossrefType "journal-article" @default.
• W2923756047 hasAuthorship W2923756047A5004181866 @default.
• W2923756047 hasAuthorship W2923756047A5005189935 @default.
• W2923756047 hasAuthorship W2923756047A5054652468 @default.
• W2923756047 hasAuthorship W2923756047A5055662535 @default.
• W2923756047 hasAuthorship W2923756047A5056376384 @default.
• W2923756047 hasBestOaLocation W29237560471 @default.
• W2923756047 hasConcept C126322002 @default.
• W2923756047 hasConcept C134018914 @default.
• W2923756047 hasConcept C142724271 @default.
• W2923756047 hasConcept C204787440 @default.
• W2923756047 hasConcept C27081682 @default.
• W2923756047 hasConcept C2777164284 @default.
• W2923756047 hasConcept C2777391703 @default.
• W2923756047 hasConcept C2778163477 @default.
• W2923756047 hasConcept C2778913445 @default.
• W2923756047 hasConcept C2779306644 @default.
• W2923756047 hasConcept C2780541478 @default.
• W2923756047 hasConcept C71924100 @default.
• W2923756047 hasConceptScore W2923756047C126322002 @default.
• W2923756047 hasConceptScore W2923756047C134018914 @default.
• W2923756047 hasConceptScore W2923756047C142724271 @default.
• W2923756047 hasConceptScore W2923756047C204787440 @default.
• W2923756047 hasConceptScore W2923756047C27081682 @default.

• next