FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923795903> ?p ?o ?g. }

• W2923795903 abstract "Breast cancer is the second most common cancer worldwide, the most common among women, and the most frequent cause of death among women in less developed regions. Trastuzumab is a humanized monoclonal antibody that downregulates the extracellular domain of the HER2 protein. Using trastuzumab to treat women with localized HER2-positive breast cancer has been shown to improve survival. The objective of this study is to explore the cost-effectiveness of adjuvant trastuzumab, from a societal perspective, in 11 African countries. In addition, we aimed to establish value-based prices for trastuzumab based on the gross domestic product per capita in each country.We developed a Markov model in order to assess the costs and benefits associated with trastuzumab treatment over a lifetime horizon. A probabilistic sensitivity analysis was performed in order to estimate the impact of uncertainty of parameter-values on the results. Efficacy inputs were derived using clinical trial data from non-African countries.In the base case analysis, trastuzumab yielded a gain ranging from 0.92 LYs in Nigeria to 1.07 LYs in South Africa, and 0.9 QALYs in Nigeria to 1.02 QALYs in South Africa. The incremental cost ranged from 19,561 USD in Nigeria to 19,997 USD in Congo, and an incremental cost-effectiveness ratio ranging from 19,534 USD/QALY in South Africa to 21,697 USD/QALY in Nigeria. Using willingness to pay estimates based on World Health Organization recommendations, trastuzumab appear to not be cost-effective in all countries analyzed. Cost-effectiveness estimates were most sensitive to the discount rate, trastuzumab cost, and the hazard ratio.Trastuzumab does not appear to be cost effective in the African countries analyzed. In order for trastuzumab to be cost-effective, the costs of treatment would require significant discounts." @default.
• W2923795903 created "2019-04-01" @default.
• W2923795903 creator A5020242154 @default.
• W2923795903 creator A5020270010 @default.
• W2923795903 creator A5025760051 @default.
• W2923795903 creator A5043150762 @default.
• W2923795903 date "2019-02-28" @default.
• W2923795903 modified "2023-10-10" @default.
• W2923795903 title "Cost effectiveness and affordability of trastuzumab in sub-Saharan Africa for early stage HER2-positive breast cancer" @default.
• W2923795903 cites W1757407923 @default.
• W2923795903 cites W1810964460 @default.
• W2923795903 cites W1967599937 @default.
• W2923795903 cites W1969875009 @default.
• W2923795903 cites W2003128904 @default.
• W2923795903 cites W2040935952 @default.
• W2923795903 cites W2045324973 @default.
• W2923795903 cites W2059170159 @default.
• W2923795903 cites W2064873973 @default.
• W2923795903 cites W2080574215 @default.
• W2923795903 cites W2084572083 @default.
• W2923795903 cites W2101253730 @default.
• W2923795903 cites W2111224984 @default.
• W2923795903 cites W2125620887 @default.
• W2923795903 cites W2134169490 @default.
• W2923795903 cites W2139107075 @default.
• W2923795903 cites W2139352067 @default.
• W2923795903 cites W2140074016 @default.
• W2923795903 cites W2140354367 @default.
• W2923795903 cites W2146803994 @default.
• W2923795903 cites W2149908785 @default.
• W2923795903 cites W2159504369 @default.
• W2923795903 cites W2162511260 @default.
• W2923795903 cites W2167093651 @default.
• W2923795903 cites W2274240919 @default.
• W2923795903 cites W2286756681 @default.
• W2923795903 cites W2335431575 @default.
• W2923795903 cites W2346129974 @default.
• W2923795903 cites W2397859874 @default.
• W2923795903 cites W2541156216 @default.
• W2923795903 cites W2557867537 @default.
• W2923795903 cites W2565886458 @default.
• W2923795903 cites W2566000157 @default.
• W2923795903 cites W2589066740 @default.
• W2923795903 cites W2599668162 @default.
• W2923795903 cites W2605358146 @default.
• W2923795903 cites W2613346504 @default.
• W2923795903 cites W2743656444 @default.
• W2923795903 cites W2782641177 @default.
• W2923795903 cites W2788205988 @default.
• W2923795903 cites W2805213545 @default.
• W2923795903 cites W2806629158 @default.
• W2923795903 cites W4236784887 @default.
• W2923795903 doi "https://doi.org/10.1186/s12962-019-0174-7" @default.
• W2923795903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6396469" @default.
• W2923795903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30867655" @default.
• W2923795903 hasPublicationYear "2019" @default.
• W2923795903 type Work @default.
• W2923795903 sameAs 2923795903 @default.
• W2923795903 citedByCount "35" @default.
• W2923795903 countsByYear W29237959032019 @default.
• W2923795903 countsByYear W29237959032020 @default.
• W2923795903 countsByYear W29237959032021 @default.
• W2923795903 countsByYear W29237959032022 @default.
• W2923795903 countsByYear W29237959032023 @default.
• W2923795903 crossrefType "journal-article" @default.
• W2923795903 hasAuthorship W2923795903A5020242154 @default.
• W2923795903 hasAuthorship W2923795903A5020270010 @default.
• W2923795903 hasAuthorship W2923795903A5025760051 @default.
• W2923795903 hasAuthorship W2923795903A5043150762 @default.
• W2923795903 hasBestOaLocation W29237959031 @default.
• W2923795903 hasConcept C112930515 @default.
• W2923795903 hasConcept C121608353 @default.
• W2923795903 hasConcept C126322002 @default.
• W2923795903 hasConcept C127598652 @default.
• W2923795903 hasConcept C143998085 @default.
• W2923795903 hasConcept C144024400 @default.
• W2923795903 hasConcept C149923435 @default.
• W2923795903 hasConcept C2779786085 @default.
• W2923795903 hasConcept C2908647359 @default.
• W2923795903 hasConcept C29456083 @default.
• W2923795903 hasConcept C3019080777 @default.
• W2923795903 hasConcept C515549039 @default.
• W2923795903 hasConcept C530470458 @default.
• W2923795903 hasConcept C71924100 @default.
• W2923795903 hasConcept C99454951 @default.
• W2923795903 hasConceptScore W2923795903C112930515 @default.
• W2923795903 hasConceptScore W2923795903C121608353 @default.
• W2923795903 hasConceptScore W2923795903C126322002 @default.
• W2923795903 hasConceptScore W2923795903C127598652 @default.
• W2923795903 hasConceptScore W2923795903C143998085 @default.
• W2923795903 hasConceptScore W2923795903C144024400 @default.
• W2923795903 hasConceptScore W2923795903C149923435 @default.
• W2923795903 hasConceptScore W2923795903C2779786085 @default.
• W2923795903 hasConceptScore W2923795903C2908647359 @default.
• W2923795903 hasConceptScore W2923795903C29456083 @default.
• W2923795903 hasConceptScore W2923795903C3019080777 @default.
• W2923795903 hasConceptScore W2923795903C515549039 @default.
• W2923795903 hasConceptScore W2923795903C530470458 @default.
• W2923795903 hasConceptScore W2923795903C71924100 @default.
• W2923795903 hasConceptScore W2923795903C99454951 @default.

• next