FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923881640> ?p ?o ?g. }

• W2923881640 abstract "Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, the nature, regulation, function, and clinical relevance of mast cells in human gastric cancer (GC) are presently unknown.Flow cytometry analyses were performed to examine level and phenotype of mast cells in samples from 114 patients with GC. Multivariate analysis of prognostic factors for overall survival was performed using the Cox proportional hazards model. Kaplan-Meier plots for patient survival were performed using the log-rank test. Mast cells, T cells and tumor cells were isolated or generated, stimulated and/or cultured for in vitro and in vivo function assays.Patients with GC showed a significantly higher mast cell infiltration in tumors. Mast cell levels increased with tumor progression and independently predicted reduced overall survival. These tumor-infiltrating mast cells accumulated in tumors by CXCL12-CXCR4 chemotaxis. Intratumoral mast cells expressed higher immunosuppressive molecule programmed death-ligand 1 (PD-L1), and mast cells induced by tumors strongly express PD-L1 proteins in both time-dependent and dose-dependent manners. Significant correlations were found between the levels of PD-L1+ mast cells and pro-inflammatory cytokine TNF-α in GC tumors, and tumor-derived TNF-α activated NF-κB signaling pathway to induce mast cell expression of PD-L1. The tumor-infiltrating and tumor-conditioned mast cells effectively suppressed normal T-cell immunity through PD-L1 in vitro, and tumor-conditioned mast cells contributed to the suppression of T-cell immunity and the growth of human GC tumors in vivo; the effect could be reversed by blocking PD-L1 on these mast cells.Thus, our results illuminate novel immunosuppressive and protumorigenic roles of mast cells in GC, and also present a novel mechanism in which PD-L1 expressing mast cells link the proinflammatory response to immune tolerance in the GC tumor milieu." @default.
• W2923881640 created "2019-04-01" @default.
• W2923881640 creator A5004846643 @default.
• W2923881640 creator A5005373133 @default.
• W2923881640 creator A5019224827 @default.
• W2923881640 creator A5025183715 @default.
• W2923881640 creator A5028611793 @default.
• W2923881640 creator A5029990401 @default.
• W2923881640 creator A5031979422 @default.
• W2923881640 creator A5033237840 @default.
• W2923881640 creator A5036472537 @default.
• W2923881640 creator A5039692056 @default.
• W2923881640 creator A5050676476 @default.
• W2923881640 creator A5051030011 @default.
• W2923881640 creator A5051306947 @default.
• W2923881640 creator A5053368619 @default.
• W2923881640 creator A5072422702 @default.
• W2923881640 creator A5080562594 @default.
• W2923881640 creator A5081093007 @default.
• W2923881640 creator A5085643062 @default.
• W2923881640 creator A5090917855 @default.
• W2923881640 date "2019-02-26" @default.
• W2923881640 modified "2023-10-15" @default.
• W2923881640 title "Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway" @default.
• W2923881640 cites W1553846656 @default.
• W2923881640 cites W1633784490 @default.
• W2923881640 cites W1913322240 @default.
• W2923881640 cites W1927075449 @default.
• W2923881640 cites W1953360647 @default.
• W2923881640 cites W1972447401 @default.
• W2923881640 cites W1991493240 @default.
• W2923881640 cites W2000422965 @default.
• W2923881640 cites W2003229125 @default.
• W2923881640 cites W2004630197 @default.
• W2923881640 cites W2007357395 @default.
• W2923881640 cites W2010862338 @default.
• W2923881640 cites W2013346434 @default.
• W2923881640 cites W2015975112 @default.
• W2923881640 cites W2019648143 @default.
• W2923881640 cites W2021237871 @default.
• W2923881640 cites W2026861011 @default.
• W2923881640 cites W2046092325 @default.
• W2923881640 cites W2051929083 @default.
• W2923881640 cites W2057393304 @default.
• W2923881640 cites W2058150019 @default.
• W2923881640 cites W2104337528 @default.
• W2923881640 cites W2111161262 @default.
• W2923881640 cites W2126868151 @default.
• W2923881640 cites W2143413473 @default.
• W2923881640 cites W2167650860 @default.
• W2923881640 cites W2172664276 @default.
• W2923881640 cites W2381763656 @default.
• W2923881640 cites W2569426717 @default.
• W2923881640 cites W2577073229 @default.
• W2923881640 cites W2593635330 @default.
• W2923881640 cites W2600859172 @default.
• W2923881640 cites W2606526654 @default.
• W2923881640 cites W2612583081 @default.
• W2923881640 cites W2617612789 @default.
• W2923881640 cites W2626512221 @default.
• W2923881640 cites W2747774814 @default.
• W2923881640 cites W2766573665 @default.
• W2923881640 cites W2791238394 @default.
• W2923881640 cites W2792256546 @default.
• W2923881640 cites W2792380195 @default.
• W2923881640 cites W2797605742 @default.
• W2923881640 cites W2806388448 @default.
• W2923881640 cites W2811001941 @default.
• W2923881640 cites W2811458542 @default.
• W2923881640 cites W2885687923 @default.
• W2923881640 cites W2892082076 @default.
• W2923881640 cites W2897319943 @default.
• W2923881640 cites W2897815318 @default.
• W2923881640 cites W4211130279 @default.
• W2923881640 doi "https://doi.org/10.1186/s40425-019-0530-3" @default.
• W2923881640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6390584" @default.
• W2923881640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30808413" @default.
• W2923881640 hasPublicationYear "2019" @default.
• W2923881640 type Work @default.
• W2923881640 sameAs 2923881640 @default.
• W2923881640 citedByCount "93" @default.
• W2923881640 countsByYear W29238816402019 @default.
• W2923881640 countsByYear W29238816402020 @default.
• W2923881640 countsByYear W29238816402021 @default.
• W2923881640 countsByYear W29238816402022 @default.
• W2923881640 countsByYear W29238816402023 @default.
• W2923881640 crossrefType "journal-article" @default.
• W2923881640 hasAuthorship W2923881640A5004846643 @default.
• W2923881640 hasAuthorship W2923881640A5005373133 @default.
• W2923881640 hasAuthorship W2923881640A5019224827 @default.
• W2923881640 hasAuthorship W2923881640A5025183715 @default.
• W2923881640 hasAuthorship W2923881640A5028611793 @default.
• W2923881640 hasAuthorship W2923881640A5029990401 @default.
• W2923881640 hasAuthorship W2923881640A5031979422 @default.
• W2923881640 hasAuthorship W2923881640A5033237840 @default.
• W2923881640 hasAuthorship W2923881640A5036472537 @default.
• W2923881640 hasAuthorship W2923881640A5039692056 @default.
• W2923881640 hasAuthorship W2923881640A5050676476 @default.
• W2923881640 hasAuthorship W2923881640A5051030011 @default.
• W2923881640 hasAuthorship W2923881640A5051306947 @default.

• next