Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923910621> ?p ?o ?g. }
- W2923910621 endingPage "92" @default.
- W2923910621 startingPage "85" @default.
- W2923910621 abstract "The detection of alkaline phosphatase (ALP) activity has received great attention since its activity in serum is highly associate with various human diseases. Herein, we describe a simple yet effective colorimetric assay for ALP activity based on polydiacetylene (PDA) and competitive binding of pyrophosphate (PPi) with calcium ions (Ca2+). PDA liposomes prepared from 10,12-pentacosadiynoic acid (PCDA) display the distinct blue-to-red color transition towards Ca2+, which can be effectively blocked by PPi due to the ultra-strong binding ability of Ca2+ with PPi. Since PPi can be specifically hydrolyzed into orthophosphate (Pi) by ALP, the negative effect of PPi could be removed when ALP is introduced into the system, thereby producing a colorimetric signal relying on ALP activity. Based on this strategy, ALP was sensitively and selectively detected with a limit of detection of 5.4 U/L. Besides, the proposed sensing method was successfully applied to evaluate the inhibitor efficiency. Detection of ALP in real human serum samples could also be achieved by this system with acceptable accuracy. As the proposed PDA liposome sensor is simple and straightforward, this strategy holds great potential as a promising alternative for ALP-based clinic diagnosis or biological research." @default.
- W2923910621 created "2019-04-01" @default.
- W2923910621 creator A5046389661 @default.
- W2923910621 creator A5058957988 @default.
- W2923910621 creator A5071520137 @default.
- W2923910621 creator A5078120538 @default.
- W2923910621 creator A5086704736 @default.
- W2923910621 creator A5086917499 @default.
- W2923910621 date "2019-06-01" @default.
- W2923910621 modified "2023-10-18" @default.
- W2923910621 title "Facile colorimetric assay of alkaline phosphatase activity using polydiacetylene liposomes with calcium ions and pyrophosphate" @default.
- W2923910621 cites W1782119342 @default.
- W2923910621 cites W1899890323 @default.
- W2923910621 cites W1964048218 @default.
- W2923910621 cites W1972006179 @default.
- W2923910621 cites W1973489530 @default.
- W2923910621 cites W1977869956 @default.
- W2923910621 cites W1981473180 @default.
- W2923910621 cites W1997624667 @default.
- W2923910621 cites W2003436477 @default.
- W2923910621 cites W2019754031 @default.
- W2923910621 cites W2020366763 @default.
- W2923910621 cites W2030829280 @default.
- W2923910621 cites W2042445442 @default.
- W2923910621 cites W2058628090 @default.
- W2923910621 cites W2060712739 @default.
- W2923910621 cites W2068270914 @default.
- W2923910621 cites W2074212062 @default.
- W2923910621 cites W2075927548 @default.
- W2923910621 cites W2100070671 @default.
- W2923910621 cites W2129549410 @default.
- W2923910621 cites W2141955432 @default.
- W2923910621 cites W2154704241 @default.
- W2923910621 cites W2269611697 @default.
- W2923910621 cites W2279898519 @default.
- W2923910621 cites W2300933535 @default.
- W2923910621 cites W2324172860 @default.
- W2923910621 cites W2324227473 @default.
- W2923910621 cites W2332536232 @default.
- W2923910621 cites W2337627606 @default.
- W2923910621 cites W2346212037 @default.
- W2923910621 cites W2346661437 @default.
- W2923910621 cites W2396056529 @default.
- W2923910621 cites W2418642045 @default.
- W2923910621 cites W2464112216 @default.
- W2923910621 cites W2521518876 @default.
- W2923910621 cites W2544786672 @default.
- W2923910621 cites W2560525166 @default.
- W2923910621 cites W2560751989 @default.
- W2923910621 cites W2588674123 @default.
- W2923910621 cites W2604156117 @default.
- W2923910621 cites W2616491738 @default.
- W2923910621 cites W2651002792 @default.
- W2923910621 cites W2766601275 @default.
- W2923910621 cites W2785760822 @default.
- W2923910621 cites W2786275139 @default.
- W2923910621 cites W2902449388 @default.
- W2923910621 cites W4245284209 @default.
- W2923910621 doi "https://doi.org/10.1016/j.snb.2019.03.087" @default.
- W2923910621 hasPublicationYear "2019" @default.
- W2923910621 type Work @default.
- W2923910621 sameAs 2923910621 @default.
- W2923910621 citedByCount "30" @default.
- W2923910621 countsByYear W29239106212019 @default.
- W2923910621 countsByYear W29239106212020 @default.
- W2923910621 countsByYear W29239106212021 @default.
- W2923910621 countsByYear W29239106212022 @default.
- W2923910621 countsByYear W29239106212023 @default.
- W2923910621 crossrefType "journal-article" @default.
- W2923910621 hasAuthorship W2923910621A5046389661 @default.
- W2923910621 hasAuthorship W2923910621A5058957988 @default.
- W2923910621 hasAuthorship W2923910621A5071520137 @default.
- W2923910621 hasAuthorship W2923910621A5078120538 @default.
- W2923910621 hasAuthorship W2923910621A5086704736 @default.
- W2923910621 hasAuthorship W2923910621A5086917499 @default.
- W2923910621 hasConcept C119128265 @default.
- W2923910621 hasConcept C13965031 @default.
- W2923910621 hasConcept C160160445 @default.
- W2923910621 hasConcept C178790620 @default.
- W2923910621 hasConcept C181199279 @default.
- W2923910621 hasConcept C185154212 @default.
- W2923910621 hasConcept C185592680 @default.
- W2923910621 hasConcept C21951064 @default.
- W2923910621 hasConcept C2776043855 @default.
- W2923910621 hasConcept C43617362 @default.
- W2923910621 hasConcept C519063684 @default.
- W2923910621 hasConcept C55493867 @default.
- W2923910621 hasConcept C94412978 @default.
- W2923910621 hasConceptScore W2923910621C119128265 @default.
- W2923910621 hasConceptScore W2923910621C13965031 @default.
- W2923910621 hasConceptScore W2923910621C160160445 @default.
- W2923910621 hasConceptScore W2923910621C178790620 @default.
- W2923910621 hasConceptScore W2923910621C181199279 @default.
- W2923910621 hasConceptScore W2923910621C185154212 @default.
- W2923910621 hasConceptScore W2923910621C185592680 @default.
- W2923910621 hasConceptScore W2923910621C21951064 @default.
- W2923910621 hasConceptScore W2923910621C2776043855 @default.
- W2923910621 hasConceptScore W2923910621C43617362 @default.