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- W2923929195 endingPage "168" @default.
- W2923929195 startingPage "159" @default.
- W2923929195 abstract "Bacterial secreted proteases are the key factors that increase the virulence potential of different pathogens. Extraintestinal pathogenic E. coli (ExPEC) is a distinct pathotype that has unique ability to infect various body sites apart from the gastrointestinal tract causing several life-threatening diseases both in human and animals. Thus, understanding of ExPEC pathogenesis is crucial in effective management of disease caused by these pathogens. It is known that ExPEC possesses a broad spectrum of virulence factors including the secreted proteases which elude the host defence system. Recent studies have shown that high prevalence as well as the action of the secreted proteases influence the pathogenesis of ExPEC. However, literature on the secreted proteases present in ExPEC and their role in promoting virulence of ExPEC is rather limited. This review describes the distribution, characterization and the role of serine and metalloproteases secreted by diverse pathotypes of ExPEC, highlighting the significance of secreted proteases of ExPEC in pathogenesis." @default.
- W2923929195 created "2019-04-01" @default.
- W2923929195 creator A5002401596 @default.
- W2923929195 creator A5013911558 @default.
- W2923929195 creator A5021075690 @default.
- W2923929195 date "2019-05-01" @default.
- W2923929195 modified "2023-10-17" @default.
- W2923929195 title "Secreted proteases: A new insight in the pathogenesis of extraintestinal pathogenic Escherichia coli" @default.
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