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• W2923948487 startingPage "1058" @default.
• W2923948487 abstract "Naltrexone is a competitive opioid receptor antagonist approved as supportive treatment in alcohol dependence and opioid addiction. At a dose of 50-100 mg daily, naltrexone is used off-label in dermatology for the treatment of trichotillomania and different types of pruritus. At a dose as low as 1- 5 mg per day, naltrexone demonstrates immunomodulatory action i.e. modulates Toll-like receptors signaling, decreases release of proinflammatory cytokines (tumor necrosis factor, interleukin-6, interleukin- 12), inhibits T lymphocyte proliferation, down-regulates the expression of chemokine receptors and adhesion molecules. The efficacy of standard and low doses of naltrexone in a variety of dermatological disorders has been reported. These include diseases such as familial benign chronic pemphigus (Hailey-Hailey disease), dermatomyositis, systemic sclerosis, psoriasis and lichen planopilaris. Optimistic preliminary findings, low cost of therapy and good tolerance make naltrexone a promising alternative therapy or adjunct drug in dermatology." @default.
• W2923948487 created "2019-04-01" @default.
• W2923948487 creator A5035483115 @default.
• W2923948487 creator A5058838543 @default.
• W2923948487 creator A5061762229 @default.
• W2923948487 creator A5082486380 @default.
• W2923948487 date "2019-07-12" @default.
• W2923948487 modified "2023-09-27" @default.
• W2923948487 title "The Use of Naltrexone in Dermatology. Current Evidence and Future Directions" @default.
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• W2923948487 doi "https://doi.org/10.2174/1389450120666190318121122" @default.
• W2923948487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30887922" @default.
• W2923948487 hasPublicationYear "2019" @default.
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