Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923966512> ?p ?o ?g. }
- W2923966512 endingPage "830" @default.
- W2923966512 startingPage "816" @default.
- W2923966512 abstract "Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like growth factor II (IGF-II) is necessary for prenatal growth, its role in adult stem cell physiology is largely unknown. We show that loss of Igf2 in adult mice resulted in a ∼50% reduction in slowly dividing, label-retaining cells in the two regions of the brain that harbor neural stem cells. Concordantly, induced Igf2 deletion increased newly generated neurons in the olfactory bulb accompanied by hyposmia, and caused impairments in learning and memory and increased anxiety. Induced Igf2 deletion also resulted in rapid loss of stem and progenitor cells in the crypts of Lieberkühn, leading to body-weight loss and lethality and the inability to produce organoids in vitro. These data demonstrate that IGF-II is critical for multiple adult stem cell niches." @default.
- W2923966512 created "2019-04-01" @default.
- W2923966512 creator A5006683878 @default.
- W2923966512 creator A5013190063 @default.
- W2923966512 creator A5015476276 @default.
- W2923966512 creator A5025465768 @default.
- W2923966512 creator A5026427036 @default.
- W2923966512 creator A5035480741 @default.
- W2923966512 creator A5038078180 @default.
- W2923966512 creator A5049834919 @default.
- W2923966512 creator A5052001271 @default.
- W2923966512 creator A5066895981 @default.
- W2923966512 creator A5072853922 @default.
- W2923966512 creator A5078554162 @default.
- W2923966512 creator A5080050746 @default.
- W2923966512 date "2019-04-01" @default.
- W2923966512 modified "2023-10-16" @default.
- W2923966512 title "Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine" @default.
- W2923966512 cites W111805191 @default.
- W2923966512 cites W1483247341 @default.
- W2923966512 cites W1538926863 @default.
- W2923966512 cites W1573822259 @default.
- W2923966512 cites W1817224745 @default.
- W2923966512 cites W1821065822 @default.
- W2923966512 cites W1872881668 @default.
- W2923966512 cites W1964118189 @default.
- W2923966512 cites W1965157206 @default.
- W2923966512 cites W1967611229 @default.
- W2923966512 cites W1970181305 @default.
- W2923966512 cites W1970351839 @default.
- W2923966512 cites W1972862259 @default.
- W2923966512 cites W1978949277 @default.
- W2923966512 cites W1982603620 @default.
- W2923966512 cites W1983456059 @default.
- W2923966512 cites W1988866946 @default.
- W2923966512 cites W1990557296 @default.
- W2923966512 cites W1993672117 @default.
- W2923966512 cites W1993677820 @default.
- W2923966512 cites W1995854660 @default.
- W2923966512 cites W1997851802 @default.
- W2923966512 cites W1998467546 @default.
- W2923966512 cites W2003299661 @default.
- W2923966512 cites W2003946492 @default.
- W2923966512 cites W2005599373 @default.
- W2923966512 cites W2007477376 @default.
- W2923966512 cites W2007573212 @default.
- W2923966512 cites W2008546738 @default.
- W2923966512 cites W2011542432 @default.
- W2923966512 cites W2011623297 @default.
- W2923966512 cites W2017632960 @default.
- W2923966512 cites W2017711029 @default.
- W2923966512 cites W2017828716 @default.
- W2923966512 cites W2017949036 @default.
- W2923966512 cites W2018100648 @default.
- W2923966512 cites W2021370278 @default.
- W2923966512 cites W2038714514 @default.
- W2923966512 cites W2038986004 @default.
- W2923966512 cites W2039557708 @default.
- W2923966512 cites W2044224616 @default.
- W2923966512 cites W2053362581 @default.
- W2923966512 cites W2054087511 @default.
- W2923966512 cites W2055917628 @default.
- W2923966512 cites W2057608998 @default.
- W2923966512 cites W2058173429 @default.
- W2923966512 cites W2061541169 @default.
- W2923966512 cites W2064394958 @default.
- W2923966512 cites W2068760639 @default.
- W2923966512 cites W2072965356 @default.
- W2923966512 cites W2078591745 @default.
- W2923966512 cites W2083813589 @default.
- W2923966512 cites W2089107351 @default.
- W2923966512 cites W2091812306 @default.
- W2923966512 cites W2094105781 @default.
- W2923966512 cites W2102321998 @default.
- W2923966512 cites W2113284270 @default.
- W2923966512 cites W2118775306 @default.
- W2923966512 cites W2119581166 @default.
- W2923966512 cites W2122787130 @default.
- W2923966512 cites W2123118366 @default.
- W2923966512 cites W2136308565 @default.
- W2923966512 cites W2139102297 @default.
- W2923966512 cites W2141535241 @default.
- W2923966512 cites W2143625921 @default.
- W2923966512 cites W2147589737 @default.
- W2923966512 cites W2156047304 @default.
- W2923966512 cites W2157010562 @default.
- W2923966512 cites W2159155233 @default.
- W2923966512 cites W2159262521 @default.
- W2923966512 cites W2162236473 @default.
- W2923966512 cites W2163035954 @default.
- W2923966512 cites W2164753229 @default.
- W2923966512 cites W2165087323 @default.
- W2923966512 cites W2165172234 @default.
- W2923966512 cites W2167163651 @default.
- W2923966512 cites W2168623286 @default.
- W2923966512 cites W2241354244 @default.
- W2923966512 cites W2807022503 @default.
- W2923966512 cites W2994709475 @default.