Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923967191> ?p ?o ?g. }
- W2923967191 endingPage "169" @default.
- W2923967191 startingPage "162" @default.
- W2923967191 abstract "Background: Growing evidence suggests a rapid antisuicidal effect of low-dose ketamine infusion in Caucasian patients with treatment-resistant depression (TRD). However, the antisuicidal effects of ketamine on Taiwanese patients with TRD remains unknown. Methods: Seventy-one patients with TRD were randomly classified into three treatment groups: 0.5 mg/kg ketamine, 0.2 mg/kg ketamine, or normal saline (placebo) infusion. The Hamilton Depression Rating Scale (HAMD) and Montgomery-Åsberg Depression Rating Scale (MADRS) were applied prior to initiation of test infusions, at 40, 80, 120, and 240 min postinfusion, and sequentially on Days 2, 3, 4, 5, 6, 7, and 14 after ketamine or placebo infusion. Item 3 (suicide) of the HAMD and item 10 (suicidal thoughts) of the MADRS were extracted for generalized estimating equation (GEE) model analyses to investigate the antisuicidal effects of ketamine infusion. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism was genotyped. Results: The GEE model revealed significant group (p = 0.007) and time (p = 0.004) effects on suicidal symptoms over times (prior to infusion to day 14 postinfusion). The group that received 0.5 mg/kg ketamine infusion exhibited a significantly lower score in item 3 of the HAMD and item 10 of the MADRS compared with the groups that received 0.2 mg/kg ketamine or placebo infusion. Among those carrying any Val allele of BDNF, both 0.5 and 0.2 mg/kg ketamine infusions were effective in reducing suicidal thoughts; however, among those with Met/Met of BDNF, only 0.5 mg/kg ketamine infusion was effective in reducing suicidal thoughts. Discussion: A single low-dose ketamine infusion was effective in reducing suicidal ideation among Taiwanese patients with TRD. BDNF Val66Met polymorphism may play a crucial role in the antisuicidal effects of ketamine infusion." @default.
- W2923967191 created "2019-04-01" @default.
- W2923967191 creator A5000579005 @default.
- W2923967191 creator A5011118280 @default.
- W2923967191 creator A5017459807 @default.
- W2923967191 creator A5026642049 @default.
- W2923967191 creator A5042168221 @default.
- W2923967191 creator A5046738774 @default.
- W2923967191 creator A5052719456 @default.
- W2923967191 creator A5059032985 @default.
- W2923967191 creator A5064155442 @default.
- W2923967191 creator A5077941048 @default.
- W2923967191 date "2019-05-01" @default.
- W2923967191 modified "2023-10-17" @default.
- W2923967191 title "Antisuicidal effect, BDNF Val66Met polymorphism, and low-dose ketamine infusion: Reanalysis of adjunctive ketamine study of Taiwanese patients with treatment-resistant depression (AKSTP-TRD)" @default.
- W2923967191 cites W1885564923 @default.
- W2923967191 cites W2000193915 @default.
- W2923967191 cites W2007445546 @default.
- W2923967191 cites W2050774254 @default.
- W2923967191 cites W2051427665 @default.
- W2923967191 cites W2065887140 @default.
- W2923967191 cites W2100735098 @default.
- W2923967191 cites W2114613490 @default.
- W2923967191 cites W2124203952 @default.
- W2923967191 cites W2127064468 @default.
- W2923967191 cites W2128918664 @default.
- W2923967191 cites W2152644978 @default.
- W2923967191 cites W2167565363 @default.
- W2923967191 cites W2254316248 @default.
- W2923967191 cites W2519531315 @default.
- W2923967191 cites W2608506675 @default.
- W2923967191 cites W2614068273 @default.
- W2923967191 cites W2738303459 @default.
- W2923967191 cites W2762798648 @default.
- W2923967191 cites W2766915693 @default.
- W2923967191 cites W2790275773 @default.
- W2923967191 cites W2883869741 @default.
- W2923967191 cites W2886961920 @default.
- W2923967191 doi "https://doi.org/10.1016/j.jad.2019.03.075" @default.
- W2923967191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30925267" @default.
- W2923967191 hasPublicationYear "2019" @default.
- W2923967191 type Work @default.
- W2923967191 sameAs 2923967191 @default.
- W2923967191 citedByCount "41" @default.
- W2923967191 countsByYear W29239671912019 @default.
- W2923967191 countsByYear W29239671912020 @default.
- W2923967191 countsByYear W29239671912021 @default.
- W2923967191 countsByYear W29239671912022 @default.
- W2923967191 countsByYear W29239671912023 @default.
- W2923967191 crossrefType "journal-article" @default.
- W2923967191 hasAuthorship W2923967191A5000579005 @default.
- W2923967191 hasAuthorship W2923967191A5011118280 @default.
- W2923967191 hasAuthorship W2923967191A5017459807 @default.
- W2923967191 hasAuthorship W2923967191A5026642049 @default.
- W2923967191 hasAuthorship W2923967191A5042168221 @default.
- W2923967191 hasAuthorship W2923967191A5046738774 @default.
- W2923967191 hasAuthorship W2923967191A5052719456 @default.
- W2923967191 hasAuthorship W2923967191A5059032985 @default.
- W2923967191 hasAuthorship W2923967191A5064155442 @default.
- W2923967191 hasAuthorship W2923967191A5077941048 @default.
- W2923967191 hasConcept C126322002 @default.
- W2923967191 hasConcept C138496976 @default.
- W2923967191 hasConcept C139719470 @default.
- W2923967191 hasConcept C142724271 @default.
- W2923967191 hasConcept C15744967 @default.
- W2923967191 hasConcept C160539049 @default.
- W2923967191 hasConcept C162324750 @default.
- W2923967191 hasConcept C170493617 @default.
- W2923967191 hasConcept C204787440 @default.
- W2923967191 hasConcept C27081682 @default.
- W2923967191 hasConcept C2776000289 @default.
- W2923967191 hasConcept C2776867660 @default.
- W2923967191 hasConcept C2777198177 @default.
- W2923967191 hasConcept C2777342061 @default.
- W2923967191 hasConcept C2778790584 @default.
- W2923967191 hasConcept C2779144063 @default.
- W2923967191 hasConcept C2780051608 @default.
- W2923967191 hasConcept C2780795376 @default.
- W2923967191 hasConcept C3018023364 @default.
- W2923967191 hasConcept C42219234 @default.
- W2923967191 hasConcept C71924100 @default.
- W2923967191 hasConcept C83849319 @default.
- W2923967191 hasConceptScore W2923967191C126322002 @default.
- W2923967191 hasConceptScore W2923967191C138496976 @default.
- W2923967191 hasConceptScore W2923967191C139719470 @default.
- W2923967191 hasConceptScore W2923967191C142724271 @default.
- W2923967191 hasConceptScore W2923967191C15744967 @default.
- W2923967191 hasConceptScore W2923967191C160539049 @default.
- W2923967191 hasConceptScore W2923967191C162324750 @default.
- W2923967191 hasConceptScore W2923967191C170493617 @default.
- W2923967191 hasConceptScore W2923967191C204787440 @default.
- W2923967191 hasConceptScore W2923967191C27081682 @default.
- W2923967191 hasConceptScore W2923967191C2776000289 @default.
- W2923967191 hasConceptScore W2923967191C2776867660 @default.
- W2923967191 hasConceptScore W2923967191C2777198177 @default.
- W2923967191 hasConceptScore W2923967191C2777342061 @default.
- W2923967191 hasConceptScore W2923967191C2778790584 @default.
- W2923967191 hasConceptScore W2923967191C2779144063 @default.