FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923967510> ?p ?o ?g. }

• W2923967510 endingPage "283" @default.
• W2923967510 startingPage "283" @default.
• W2923967510 abstract "This study was conducted to elucidate the involvement of the PINK1-Parkin pathway in ethanol-induced mitophagy among Sertoli cells (SCs). In the research, adult rats were given intraperitoneal injections of ethanol (5 gm/kg) and sacrificed at various time periods within 24 h. Transmission electron microscopy was applied to reveal enhanced mitochondrial damage in SCs of the ethanol-treated rats (ETRs) in association with a significant increase in numbers of mitophagic vacuoles (mitophagosomes and autolysosomes) in contrast to very low levels in a control group treated with phosphate-buffered saline (PBS). This enhancement was ultra-structurally verified via observation of trapped mitochondria within LC3-labeled membranes, upregulation of LC3 protein levels, colocalization of LC3 and cytochrome c, and reduced expression of mitochondrial proteins. Importantly, Parkin expression was found to be upregulated in ETR SCs, specifically in mitochondria and mitophagosomes in addition to colocalization with PINK1 and pan-cathepsin, indicating augmented mitophagy. Transcription factor EB (TFEB, a transcription factor for autophagy and mitophagy proteins) was also found to be upregulated in nuclei of ETR SCs and associated with enhanced expression of iNOS. Enhanced Parkin-related mitophagy in ETR SCs may be a protective mechanism with therapeutic implications. To the authors’ knowledge, this is the first report demonstrating the ultrastructural characteristics and molecular mechanisms of Parkin-related mitophagy in ETR SCs." @default.
• W2923967510 created "2019-04-01" @default.
• W2923967510 creator A5024652836 @default.
• W2923967510 creator A5026381335 @default.
• W2923967510 creator A5034500908 @default.
• W2923967510 creator A5052074447 @default.
• W2923967510 creator A5071512243 @default.
• W2923967510 date "2019-03-25" @default.
• W2923967510 modified "2023-09-30" @default.
• W2923967510 title "Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy" @default.
• W2923967510 cites W1511003303 @default.
• W2923967510 cites W1851431531 @default.
• W2923967510 cites W1995966034 @default.
• W2923967510 cites W2000065315 @default.
• W2923967510 cites W2000913561 @default.
• W2923967510 cites W2015589839 @default.
• W2923967510 cites W2023448800 @default.
• W2923967510 cites W2029319331 @default.
• W2923967510 cites W2035692638 @default.
• W2923967510 cites W2054193843 @default.
• W2923967510 cites W2055834061 @default.
• W2923967510 cites W2064028385 @default.
• W2923967510 cites W2081522223 @default.
• W2923967510 cites W2105088586 @default.
• W2923967510 cites W2106444069 @default.
• W2923967510 cites W2117339132 @default.
• W2923967510 cites W2118787902 @default.
• W2923967510 cites W2123611234 @default.
• W2923967510 cites W2139117716 @default.
• W2923967510 cites W2141572838 @default.
• W2923967510 cites W2142219689 @default.
• W2923967510 cites W2155015733 @default.
• W2923967510 cites W2157096314 @default.
• W2923967510 cites W2164367561 @default.
• W2923967510 cites W2168072934 @default.
• W2923967510 cites W2273029159 @default.
• W2923967510 cites W2289566380 @default.
• W2923967510 cites W2326435378 @default.
• W2923967510 cites W2345299272 @default.
• W2923967510 cites W2396474445 @default.
• W2923967510 cites W2508283937 @default.
• W2923967510 cites W2514673286 @default.
• W2923967510 cites W2516126943 @default.
• W2923967510 cites W2560254398 @default.
• W2923967510 cites W2611983368 @default.
• W2923967510 cites W2616267086 @default.
• W2923967510 cites W2620313366 @default.
• W2923967510 cites W2747407286 @default.
• W2923967510 cites W2790745093 @default.
• W2923967510 cites W2793407457 @default.
• W2923967510 cites W2887998229 @default.
• W2923967510 cites W2907248296 @default.
• W2923967510 cites W2911248861 @default.
• W2923967510 cites W2914084525 @default.
• W2923967510 cites W2982023393 @default.
• W2923967510 doi "https://doi.org/10.3390/cells8030283" @default.
• W2923967510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6468925" @default.
• W2923967510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30934625" @default.
• W2923967510 hasPublicationYear "2019" @default.
• W2923967510 type Work @default.
• W2923967510 sameAs 2923967510 @default.
• W2923967510 citedByCount "19" @default.
• W2923967510 countsByYear W29239675102019 @default.
• W2923967510 countsByYear W29239675102020 @default.
• W2923967510 countsByYear W29239675102021 @default.
• W2923967510 countsByYear W29239675102022 @default.
• W2923967510 countsByYear W29239675102023 @default.
• W2923967510 crossrefType "journal-article" @default.
• W2923967510 hasAuthorship W2923967510A5024652836 @default.
• W2923967510 hasAuthorship W2923967510A5026381335 @default.
• W2923967510 hasAuthorship W2923967510A5034500908 @default.
• W2923967510 hasAuthorship W2923967510A5052074447 @default.
• W2923967510 hasAuthorship W2923967510A5071512243 @default.
• W2923967510 hasBestOaLocation W29239675101 @default.
• W2923967510 hasConcept C104317684 @default.
• W2923967510 hasConcept C126322002 @default.
• W2923967510 hasConcept C127561419 @default.
• W2923967510 hasConcept C185592680 @default.
• W2923967510 hasConcept C190283241 @default.
• W2923967510 hasConcept C203522944 @default.
• W2923967510 hasConcept C2776804853 @default.
• W2923967510 hasConcept C2777668072 @default.
• W2923967510 hasConcept C2779134260 @default.
• W2923967510 hasConcept C2779324830 @default.
• W2923967510 hasConcept C2779734285 @default.
• W2923967510 hasConcept C28859421 @default.
• W2923967510 hasConcept C40209533 @default.
• W2923967510 hasConcept C55493867 @default.
• W2923967510 hasConcept C71924100 @default.
• W2923967510 hasConcept C86803240 @default.
• W2923967510 hasConcept C95444343 @default.
• W2923967510 hasConceptScore W2923967510C104317684 @default.
• W2923967510 hasConceptScore W2923967510C126322002 @default.
• W2923967510 hasConceptScore W2923967510C127561419 @default.
• W2923967510 hasConceptScore W2923967510C185592680 @default.
• W2923967510 hasConceptScore W2923967510C190283241 @default.
• W2923967510 hasConceptScore W2923967510C203522944 @default.
• W2923967510 hasConceptScore W2923967510C2776804853 @default.

• next