FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924097665> ?p ?o ?g. }

• W2924097665 endingPage "7683" @default.
• W2924097665 startingPage "7667" @default.
• W2924097665 abstract "Current pharmacological intervention for the treatment of osteolytic bone diseases such as osteoporosis focuses on the prevention of excessive osteoclastic bone resorption but does not enhance osteoblast-mediated bone formation. In our study, we have shown that 4-iodo-6-phenylpyrimidine (4-IPP), an irreversible inhibitor of macrophage migration inhibitory factor (MIF), can inhibit receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and potentiate osteoblast-mediated mineralization and bone nodule formation in vitro. Mechanistically, 4-IPP inhibited RANKL-induced p65 phosphorylation and nuclear translocation by preventing the interaction of MIF with thioredoxin-interacting protein-p65 complexes. This led to the suppression of late osteoclast marker genes such as nuclear factor of activated T cells cytoplasmic 1, resulting in impaired osteoclast formation. In contrast, 4-IPP potentiated osteoblast differentiation and mineralization also through the inhibition of the p65/NF-κB signaling cascade. In the murine model of pathologic osteolysis induced by titanium particles, 4-IPP protected against calvarial bone destruction. Similarly, in the murine model of ovariectomy-induced osteoporosis, 4-IPP treatment ameliorated the bone loss associated with estrogen deficiency by reducing osteoclastic activities and enhancing osteoblastic bone formation. Collectively, these findings provide evidence for the pharmacological targeting of MIF for the treatment of osteolytic bone disorders.-Zheng, L., Gao, J., Jin, K., Chen, Z., Yu, W., Zhu, K., Huang, W., Liu, F., Mei, L., Lou, C., He, D. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway." @default.
• W2924097665 created "2019-04-01" @default.
• W2924097665 creator A5004695623 @default.
• W2924097665 creator A5006748765 @default.
• W2924097665 creator A5007979461 @default.
• W2924097665 creator A5015838072 @default.
• W2924097665 creator A5027735250 @default.
• W2924097665 creator A5029346333 @default.
• W2924097665 creator A5044801301 @default.
• W2924097665 creator A5056578782 @default.
• W2924097665 creator A5063021458 @default.
• W2924097665 creator A5074936933 @default.
• W2924097665 creator A5091755280 @default.
• W2924097665 date "2019-03-20" @default.
• W2924097665 modified "2023-10-17" @default.
• W2924097665 title "Macrophage migration inhibitory factor (MIF) inhibitor 4‐IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF‐κB signaling pathway" @default.
• W2924097665 cites W1507322431 @default.
• W2924097665 cites W1513928844 @default.
• W2924097665 cites W1642259399 @default.
• W2924097665 cites W1978551760 @default.
• W2924097665 cites W1979455711 @default.
• W2924097665 cites W1984533078 @default.
• W2924097665 cites W1984821835 @default.
• W2924097665 cites W1986128158 @default.
• W2924097665 cites W1986837253 @default.
• W2924097665 cites W1988250064 @default.
• W2924097665 cites W1999191094 @default.
• W2924097665 cites W2001634895 @default.
• W2924097665 cites W2002211752 @default.
• W2924097665 cites W2004316687 @default.
• W2924097665 cites W2012103481 @default.
• W2924097665 cites W2024525376 @default.
• W2924097665 cites W2028978931 @default.
• W2924097665 cites W2029174607 @default.
• W2924097665 cites W2038773592 @default.
• W2924097665 cites W2046055623 @default.
• W2924097665 cites W2049310294 @default.
• W2924097665 cites W2062872099 @default.
• W2924097665 cites W2066749771 @default.
• W2924097665 cites W2068058635 @default.
• W2924097665 cites W2084622111 @default.
• W2924097665 cites W2087441379 @default.
• W2924097665 cites W2090056328 @default.
• W2924097665 cites W2090279266 @default.
• W2924097665 cites W2091029032 @default.
• W2924097665 cites W2093252878 @default.
• W2924097665 cites W2096425957 @default.
• W2924097665 cites W2099484036 @default.
• W2924097665 cites W2110929110 @default.
• W2924097665 cites W2118495599 @default.
• W2924097665 cites W2143518473 @default.
• W2924097665 cites W2146058212 @default.
• W2924097665 cites W2153226227 @default.
• W2924097665 cites W2162068180 @default.
• W2924097665 cites W2212319200 @default.
• W2924097665 cites W2296384316 @default.
• W2924097665 cites W2338269537 @default.
• W2924097665 cites W2345489314 @default.
• W2924097665 cites W2370489452 @default.
• W2924097665 cites W2461771786 @default.
• W2924097665 cites W2590696895 @default.
• W2924097665 cites W2595356781 @default.
• W2924097665 cites W2623534687 @default.
• W2924097665 cites W2767133282 @default.
• W2924097665 cites W2770652917 @default.
• W2924097665 doi "https://doi.org/10.1096/fj.201802364rr" @default.
• W2924097665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30893559" @default.
• W2924097665 hasPublicationYear "2019" @default.
• W2924097665 type Work @default.
• W2924097665 sameAs 2924097665 @default.
• W2924097665 citedByCount "28" @default.
• W2924097665 countsByYear W29240976652019 @default.
• W2924097665 countsByYear W29240976652020 @default.
• W2924097665 countsByYear W29240976652021 @default.
• W2924097665 countsByYear W29240976652022 @default.
• W2924097665 countsByYear W29240976652023 @default.
• W2924097665 crossrefType "journal-article" @default.
• W2924097665 hasAuthorship W2924097665A5004695623 @default.
• W2924097665 hasAuthorship W2924097665A5006748765 @default.
• W2924097665 hasAuthorship W2924097665A5007979461 @default.
• W2924097665 hasAuthorship W2924097665A5015838072 @default.
• W2924097665 hasAuthorship W2924097665A5027735250 @default.
• W2924097665 hasAuthorship W2924097665A5029346333 @default.
• W2924097665 hasAuthorship W2924097665A5044801301 @default.
• W2924097665 hasAuthorship W2924097665A5056578782 @default.
• W2924097665 hasAuthorship W2924097665A5063021458 @default.
• W2924097665 hasAuthorship W2924097665A5074936933 @default.
• W2924097665 hasAuthorship W2924097665A5091755280 @default.
• W2924097665 hasBestOaLocation W29240976651 @default.
• W2924097665 hasConcept C104177226 @default.
• W2924097665 hasConcept C126322002 @default.
• W2924097665 hasConcept C134018914 @default.
• W2924097665 hasConcept C141071460 @default.
• W2924097665 hasConcept C170493617 @default.
• W2924097665 hasConcept C185592680 @default.
• W2924097665 hasConcept C202751555 @default.
• W2924097665 hasConcept C2776033226 @default.
• W2924097665 hasConcept C2777730290 @default.

• next