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• W2924117543 abstract "Background:Despite the well-documented relationship between lobar cerebral microbleeds (lCMB) and Alzheimer’s disease (AD), there is limited knowledge about the role of lCMB in AD pathology. Objective:To understand the nature of this relationship, we investigated the association between lCMB, amylo id load, perfusion, and metabolism. Methods:Participants with AD, mild cognitive impairment (MCI), and healthy controls were recruited and scanned with 11C-Pittsburg-Compound B (PiB), Fluorodeoxyglucose (FDG) PET, and susceptibility-weighted MRI. Early PiB-PET frames were used to estimate perfusion. The association between lCMB and PET uptake in each anatomical lobe was measured using multiple regression models. Results:The presence of lCMB predicted increased total (p < 0.001) and regional (p = 0.0002) PiB uptake, as well as decreased cerebral perfusion (p = 0.03). Cases with lCMB had hypometabolism in their temporal lobe (p = 0.04). Conclusion:There are significant relationships between lCMBs and various markers of AD pathology. lCMB has a spatial association with Aβ load and a complex effect on perfusion and metabolism." @default.
• W2924117543 created "2019-04-01" @default.
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• W2924117543 date "2019-04-23" @default.
• W2924117543 modified "2023-10-18" @default.
• W2924117543 title "Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer’s Disease" @default.
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• W2924117543 doi "https://doi.org/10.3233/jad-180443" @default.
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• W2924117543 hasPublicationYear "2019" @default.
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