FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924127868> ?p ?o ?g. }

• W2924127868 endingPage "108804" @default.
• W2924127868 startingPage "108804" @default.
• W2924127868 abstract "B lymphocytes have been shown to contribute to autoimmune diseases via producing antibodies and proinflammatory cytokines. Depletion of B cells by blocking CD20 can inhibit these diseases. Here we examined whether an antibody against CD20, rituximab (RTX) (Rituxan@), used clinically in oncology could have similar anti-inflammatory effects in cardiac remodeling and heart failure (HF) in mice. Cardiac remodeling was established by pressure overload induced by transverse aortic constriction (TAC). Wild-type (WT) male C57BL/6 J mice were subjected to pressure overload by using transverse aortic constriction and then received RTX for 4 weeks. Administration of RTX markedly improves in vivo heart function, and suppressed heart chamber dilation, myocyte hypertrophy, fibrosis and oxidative stress in mice after TAC operation. RTX treatment also reversed established hypertrophic remodeling induced by TAC. Moreover, TAC-induced activation of multiple signaling pathways including calcineurin A, ERK1/2, STAT3, TGFβ/Smad2/3 and IKKα/β/NF-kB were remarkably attenuated in RTX-treated hearts compared with controls. These inhibitory effects of RTX were associated with inhibition of proinflammatory cytokine expression and Th2 cytokine-mediated IgG production from B cells. In conclusion, this study identifies that administration of RTX can inhibit pressure overload-induced cardiac remodeling and dysfunction in mice, and suggest that RTX may be a promising drug for treating hypertrophic disease." @default.
• W2924127868 created "2019-04-01" @default.
• W2924127868 creator A5028829196 @default.
• W2924127868 creator A5031524039 @default.
• W2924127868 creator A5055565843 @default.
• W2924127868 creator A5056140696 @default.
• W2924127868 creator A5073216396 @default.
• W2924127868 creator A5090774841 @default.
• W2924127868 date "2019-06-01" @default.
• W2924127868 modified "2023-10-18" @default.
• W2924127868 title "Rituximab prevents and reverses cardiac remodeling by depressing B cell function in mice" @default.
• W2924127868 cites W1538852380 @default.
• W2924127868 cites W1929509592 @default.
• W2924127868 cites W1967290306 @default.
• W2924127868 cites W1977585353 @default.
• W2924127868 cites W1984235771 @default.
• W2924127868 cites W1984281014 @default.
• W2924127868 cites W2010431766 @default.
• W2924127868 cites W2011811777 @default.
• W2924127868 cites W2016986936 @default.
• W2924127868 cites W2021257197 @default.
• W2924127868 cites W2048443754 @default.
• W2924127868 cites W2051543984 @default.
• W2924127868 cites W2058856567 @default.
• W2924127868 cites W2064106373 @default.
• W2924127868 cites W2064739203 @default.
• W2924127868 cites W2064752763 @default.
• W2924127868 cites W2065134144 @default.
• W2924127868 cites W2109723575 @default.
• W2924127868 cites W2119326707 @default.
• W2924127868 cites W2125044993 @default.
• W2924127868 cites W2151777700 @default.
• W2924127868 cites W2185958617 @default.
• W2924127868 cites W2273550228 @default.
• W2924127868 cites W2466794211 @default.
• W2924127868 cites W2621342262 @default.
• W2924127868 cites W2730107310 @default.
• W2924127868 cites W2792454313 @default.
• W2924127868 cites W2895757545 @default.
• W2924127868 cites W2896253748 @default.
• W2924127868 cites W2898775852 @default.
• W2924127868 cites W2898919360 @default.
• W2924127868 cites W2903562879 @default.
• W2924127868 doi "https://doi.org/10.1016/j.biopha.2019.108804" @default.
• W2924127868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30909146" @default.
• W2924127868 hasPublicationYear "2019" @default.
• W2924127868 type Work @default.
• W2924127868 sameAs 2924127868 @default.
• W2924127868 citedByCount "23" @default.
• W2924127868 countsByYear W29241278682020 @default.
• W2924127868 countsByYear W29241278682021 @default.
• W2924127868 countsByYear W29241278682022 @default.
• W2924127868 countsByYear W29241278682023 @default.
• W2924127868 crossrefType "journal-article" @default.
• W2924127868 hasAuthorship W2924127868A5028829196 @default.
• W2924127868 hasAuthorship W2924127868A5031524039 @default.
• W2924127868 hasAuthorship W2924127868A5055565843 @default.
• W2924127868 hasAuthorship W2924127868A5056140696 @default.
• W2924127868 hasAuthorship W2924127868A5073216396 @default.
• W2924127868 hasAuthorship W2924127868A5090774841 @default.
• W2924127868 hasBestOaLocation W29241278681 @default.
• W2924127868 hasConcept C111566952 @default.
• W2924127868 hasConcept C126322002 @default.
• W2924127868 hasConcept C128057223 @default.
• W2924127868 hasConcept C134018914 @default.
• W2924127868 hasConcept C159654299 @default.
• W2924127868 hasConcept C164027704 @default.
• W2924127868 hasConcept C167414201 @default.
• W2924127868 hasConcept C198710026 @default.
• W2924127868 hasConcept C203014093 @default.
• W2924127868 hasConcept C2776914184 @default.
• W2924127868 hasConcept C2778198053 @default.
• W2924127868 hasConcept C2778271984 @default.
• W2924127868 hasConcept C2778690821 @default.
• W2924127868 hasConcept C2779537366 @default.
• W2924127868 hasConcept C2779838083 @default.
• W2924127868 hasConcept C2780559512 @default.
• W2924127868 hasConcept C2780653079 @default.
• W2924127868 hasConcept C2908929049 @default.
• W2924127868 hasConcept C2911091166 @default.
• W2924127868 hasConcept C3018791406 @default.
• W2924127868 hasConcept C71924100 @default.
• W2924127868 hasConcept C84393581 @default.
• W2924127868 hasConcept C98274493 @default.
• W2924127868 hasConceptScore W2924127868C111566952 @default.
• W2924127868 hasConceptScore W2924127868C126322002 @default.
• W2924127868 hasConceptScore W2924127868C128057223 @default.
• W2924127868 hasConceptScore W2924127868C134018914 @default.
• W2924127868 hasConceptScore W2924127868C159654299 @default.
• W2924127868 hasConceptScore W2924127868C164027704 @default.
• W2924127868 hasConceptScore W2924127868C167414201 @default.
• W2924127868 hasConceptScore W2924127868C198710026 @default.
• W2924127868 hasConceptScore W2924127868C203014093 @default.
• W2924127868 hasConceptScore W2924127868C2776914184 @default.
• W2924127868 hasConceptScore W2924127868C2778198053 @default.
• W2924127868 hasConceptScore W2924127868C2778271984 @default.
• W2924127868 hasConceptScore W2924127868C2778690821 @default.
• W2924127868 hasConceptScore W2924127868C2779537366 @default.

• next