Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924140265> ?p ?o ?g. }
- W2924140265 abstract "Abstract Hox genes are evolutionarily conserved transcription factors that during embryonic development function as master regulators of positional identity. In postnatal life, the function of Hox proteins is less clear: Hox genes are expressed during tissue repair, but in this context their function(s) are largely unknown. Here we show that Hox genes are expressed in periosteal stem/progenitor cells in a distribution similar to that during embryonic development. Using unbiased sequencing, we established that periosteal stem/progenitor cells from distinct anatomic sites within the skeleton significantly differ in their transcriptome, and that Hox expression status best defines these differences. Lastly, we provide evidence that Hox gene expression is one potential mechanism that maintains periosteal stem/progenitor cells in a more primitive, tripotent state, while suppression of Hox genes leads to fate changes with loss of tripotency. Together, our data describe an adult role of Hox genes other than positional identity, and the modulatory role of Hox genes in fate decisions may offer potential druggable targets for the treatment of fractures, non-unions and bone defects." @default.
- W2924140265 created "2019-04-01" @default.
- W2924140265 creator A5013092294 @default.
- W2924140265 creator A5023790589 @default.
- W2924140265 creator A5025801281 @default.
- W2924140265 creator A5032850501 @default.
- W2924140265 creator A5056241109 @default.
- W2924140265 creator A5058203137 @default.
- W2924140265 creator A5078087984 @default.
- W2924140265 creator A5084678254 @default.
- W2924140265 creator A5086650077 @default.
- W2924140265 date "2019-03-25" @default.
- W2924140265 modified "2023-10-18" @default.
- W2924140265 title "Hox gene expression determines cell fate of adult periosteal stem/progenitor cells" @default.
- W2924140265 cites W1834348670 @default.
- W2924140265 cites W1960646300 @default.
- W2924140265 cites W1982234682 @default.
- W2924140265 cites W1985052925 @default.
- W2924140265 cites W1994643992 @default.
- W2924140265 cites W2012330620 @default.
- W2924140265 cites W2047305416 @default.
- W2924140265 cites W2051911149 @default.
- W2924140265 cites W2065704432 @default.
- W2924140265 cites W2067056216 @default.
- W2924140265 cites W2069235384 @default.
- W2924140265 cites W2075794898 @default.
- W2924140265 cites W2076221823 @default.
- W2924140265 cites W2078719918 @default.
- W2924140265 cites W2110091762 @default.
- W2924140265 cites W2113002117 @default.
- W2924140265 cites W2116236561 @default.
- W2924140265 cites W2119666376 @default.
- W2924140265 cites W2120989136 @default.
- W2924140265 cites W2134101898 @default.
- W2924140265 cites W2137256580 @default.
- W2924140265 cites W2156952955 @default.
- W2924140265 cites W2171282651 @default.
- W2924140265 cites W2187474026 @default.
- W2924140265 cites W2276501963 @default.
- W2924140265 cites W2531326375 @default.
- W2924140265 cites W2552330831 @default.
- W2924140265 cites W2560095183 @default.
- W2924140265 cites W2567004306 @default.
- W2924140265 cites W2610445061 @default.
- W2924140265 cites W2790664419 @default.
- W2924140265 cites W2891678928 @default.
- W2924140265 cites W2949205080 @default.
- W2924140265 doi "https://doi.org/10.1038/s41598-019-41639-7" @default.
- W2924140265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6434021" @default.
- W2924140265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30911091" @default.
- W2924140265 hasPublicationYear "2019" @default.
- W2924140265 type Work @default.
- W2924140265 sameAs 2924140265 @default.
- W2924140265 citedByCount "21" @default.
- W2924140265 countsByYear W29241402652019 @default.
- W2924140265 countsByYear W29241402652020 @default.
- W2924140265 countsByYear W29241402652021 @default.
- W2924140265 countsByYear W29241402652022 @default.
- W2924140265 countsByYear W29241402652023 @default.
- W2924140265 crossrefType "journal-article" @default.
- W2924140265 hasAuthorship W2924140265A5013092294 @default.
- W2924140265 hasAuthorship W2924140265A5023790589 @default.
- W2924140265 hasAuthorship W2924140265A5025801281 @default.
- W2924140265 hasAuthorship W2924140265A5032850501 @default.
- W2924140265 hasAuthorship W2924140265A5056241109 @default.
- W2924140265 hasAuthorship W2924140265A5058203137 @default.
- W2924140265 hasAuthorship W2924140265A5078087984 @default.
- W2924140265 hasAuthorship W2924140265A5084678254 @default.
- W2924140265 hasAuthorship W2924140265A5086650077 @default.
- W2924140265 hasBestOaLocation W29241402651 @default.
- W2924140265 hasConcept C104317684 @default.
- W2924140265 hasConcept C111039654 @default.
- W2924140265 hasConcept C145103041 @default.
- W2924140265 hasConcept C150194340 @default.
- W2924140265 hasConcept C162317418 @default.
- W2924140265 hasConcept C163952510 @default.
- W2924140265 hasConcept C201750760 @default.
- W2924140265 hasConcept C28328180 @default.
- W2924140265 hasConcept C54355233 @default.
- W2924140265 hasConcept C86339819 @default.
- W2924140265 hasConcept C86803240 @default.
- W2924140265 hasConcept C95444343 @default.
- W2924140265 hasConceptScore W2924140265C104317684 @default.
- W2924140265 hasConceptScore W2924140265C111039654 @default.
- W2924140265 hasConceptScore W2924140265C145103041 @default.
- W2924140265 hasConceptScore W2924140265C150194340 @default.
- W2924140265 hasConceptScore W2924140265C162317418 @default.
- W2924140265 hasConceptScore W2924140265C163952510 @default.
- W2924140265 hasConceptScore W2924140265C201750760 @default.
- W2924140265 hasConceptScore W2924140265C28328180 @default.
- W2924140265 hasConceptScore W2924140265C54355233 @default.
- W2924140265 hasConceptScore W2924140265C86339819 @default.
- W2924140265 hasConceptScore W2924140265C86803240 @default.
- W2924140265 hasConceptScore W2924140265C95444343 @default.
- W2924140265 hasFunder F4320337362 @default.
- W2924140265 hasIssue "1" @default.
- W2924140265 hasLocation W29241402651 @default.
- W2924140265 hasLocation W29241402652 @default.
- W2924140265 hasLocation W29241402653 @default.
- W2924140265 hasOpenAccess W2924140265 @default.