FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924142746> ?p ?o ?g. }

• W2924142746 endingPage "e0212784" @default.
• W2924142746 startingPage "e0212784" @default.
• W2924142746 abstract "Background International guidelines lack a substantial consensus regarding management of asymptomatic full-term and late preterm neonates at risk for early-onset disease (EOS). Large cohorts of newborns are suitable to increase the understanding of the safety and efficacy of a given strategy. Methods This is a prospective, area-based, cohort study involving regional birth facilities of Emilia-Romagna (Italy). We compared cases of EOS (at or above 35 weeks’ gestation) registered in 2003–2009 (baseline period: 266,646 LBs) and in 2010–2016, after introduction of a new strategy (serial physical examinations, SPEs) for managing asymptomatic neonates at risk for EOS (intervention period: 265,508 LBs). Results There were 108 cases of EOS (baseline period, n = 60; intervention period, n = 48). Twenty-two (20.4%) remained asymptomatic through the first 72 hours of life, whereas 86 (79.6%) developed symptoms, in most cases (52/86, 60.5%) at birth or within 6 hours. The median age at presentation was significantly earlier in the intrapartum antibiotic prophylaxis (IAP)-exposed than in the IAP-unexposed neonates (0 hours, IQR 0.0000–0.0000 vs 6 hours, IQR 0.0000–15.0000, p<0.001). High number of neonates (n = 531) asymptomatic at birth, exposed to intrapartum fever, should be treated empirically for each newborn who subsequently develops sepsis. IAP exposed neonates increased (12% vs 33%, p = 0.01), age at presentation decreased (median 6 vs 1 hours, p = 0.01), whereas meningitis, mechanical ventilation and mortality did not change in baseline vs intervention period. After implementing the SPEs, no cases had adverse outcomes due to the strategy, and no cases developed severe disease after 6 hours of life. Conclusions Infants with EOS exposed to IAP developed symptoms at birth in almost all cases, and those who appeared well at birth had a very low chance of having EOS. The risk of EOS in neonates (asymptomatic at birth) exposed to intrapartum fever was low. Although definite conclusions on causation are lacking, our data support SPEs of asymptomatic newborns at risk for EOS. SPEs seems a safe and effective alternative to laboratory screening and empirical antibiotic therapy." @default.
• W2924142746 created "2019-04-01" @default.
• W2924142746 creator A5025189563 @default.
• W2924142746 creator A5026025292 @default.
• W2924142746 creator A5027748806 @default.
• W2924142746 creator A5031793628 @default.
• W2924142746 creator A5033946527 @default.
• W2924142746 creator A5034315615 @default.
• W2924142746 creator A5037330878 @default.
• W2924142746 creator A5038727106 @default.
• W2924142746 creator A5039324871 @default.
• W2924142746 creator A5043451240 @default.
• W2924142746 creator A5046309757 @default.
• W2924142746 creator A5071446226 @default.
• W2924142746 creator A5080583446 @default.
• W2924142746 creator A5081304321 @default.
• W2924142746 creator A5085026814 @default.
• W2924142746 date "2019-03-20" @default.
• W2924142746 modified "2023-09-23" @default.
• W2924142746 title "Group B Streptococcus early-onset disease and observation of well-appearing newborns" @default.
• W2924142746 cites W1829505854 @default.
• W2924142746 cites W1854176043 @default.
• W2924142746 cites W2022677792 @default.
• W2924142746 cites W2038538412 @default.
• W2924142746 cites W2069023210 @default.
• W2924142746 cites W2071824064 @default.
• W2924142746 cites W2089326901 @default.
• W2924142746 cites W2124992614 @default.
• W2924142746 cites W2316592952 @default.
• W2924142746 cites W2348296881 @default.
• W2924142746 cites W2397332045 @default.
• W2924142746 cites W2517669285 @default.
• W2924142746 cites W2549742976 @default.
• W2924142746 cites W2592958094 @default.
• W2924142746 cites W2593600449 @default.
• W2924142746 cites W2616251258 @default.
• W2924142746 cites W2777601894 @default.
• W2924142746 cites W2791614007 @default.
• W2924142746 cites W2794973784 @default.
• W2924142746 cites W4256758994 @default.
• W2924142746 doi "https://doi.org/10.1371/journal.pone.0212784" @default.
• W2924142746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6426194" @default.
• W2924142746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30893310" @default.
• W2924142746 hasPublicationYear "2019" @default.
• W2924142746 type Work @default.
• W2924142746 sameAs 2924142746 @default.
• W2924142746 citedByCount "20" @default.
• W2924142746 countsByYear W29241427462019 @default.
• W2924142746 countsByYear W29241427462020 @default.
• W2924142746 countsByYear W29241427462021 @default.
• W2924142746 countsByYear W29241427462022 @default.
• W2924142746 countsByYear W29241427462023 @default.
• W2924142746 crossrefType "journal-article" @default.
• W2924142746 hasAuthorship W2924142746A5025189563 @default.
• W2924142746 hasAuthorship W2924142746A5026025292 @default.
• W2924142746 hasAuthorship W2924142746A5027748806 @default.
• W2924142746 hasAuthorship W2924142746A5031793628 @default.
• W2924142746 hasAuthorship W2924142746A5033946527 @default.
• W2924142746 hasAuthorship W2924142746A5034315615 @default.
• W2924142746 hasAuthorship W2924142746A5037330878 @default.
• W2924142746 hasAuthorship W2924142746A5038727106 @default.
• W2924142746 hasAuthorship W2924142746A5039324871 @default.
• W2924142746 hasAuthorship W2924142746A5043451240 @default.
• W2924142746 hasAuthorship W2924142746A5046309757 @default.
• W2924142746 hasAuthorship W2924142746A5071446226 @default.
• W2924142746 hasAuthorship W2924142746A5080583446 @default.
• W2924142746 hasAuthorship W2924142746A5081304321 @default.
• W2924142746 hasAuthorship W2924142746A5085026814 @default.
• W2924142746 hasBestOaLocation W29241427461 @default.
• W2924142746 hasConcept C126322002 @default.
• W2924142746 hasConcept C187212893 @default.
• W2924142746 hasConcept C188816634 @default.
• W2924142746 hasConcept C2777910003 @default.
• W2924142746 hasConcept C2778384902 @default.
• W2924142746 hasConcept C2779234561 @default.
• W2924142746 hasConcept C2781026528 @default.
• W2924142746 hasConcept C46973012 @default.
• W2924142746 hasConcept C54355233 @default.
• W2924142746 hasConcept C71924100 @default.
• W2924142746 hasConcept C72563966 @default.
• W2924142746 hasConcept C86803240 @default.
• W2924142746 hasConceptScore W2924142746C126322002 @default.
• W2924142746 hasConceptScore W2924142746C187212893 @default.
• W2924142746 hasConceptScore W2924142746C188816634 @default.
• W2924142746 hasConceptScore W2924142746C2777910003 @default.
• W2924142746 hasConceptScore W2924142746C2778384902 @default.
• W2924142746 hasConceptScore W2924142746C2779234561 @default.
• W2924142746 hasConceptScore W2924142746C2781026528 @default.
• W2924142746 hasConceptScore W2924142746C46973012 @default.
• W2924142746 hasConceptScore W2924142746C54355233 @default.
• W2924142746 hasConceptScore W2924142746C71924100 @default.
• W2924142746 hasConceptScore W2924142746C72563966 @default.
• W2924142746 hasConceptScore W2924142746C86803240 @default.
• W2924142746 hasIssue "3" @default.
• W2924142746 hasLocation W29241427461 @default.
• W2924142746 hasLocation W29241427462 @default.
• W2924142746 hasLocation W29241427463 @default.
• W2924142746 hasLocation W29241427464 @default.

• next