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• W2924157074 startingPage "19" @default.
• W2924157074 abstract "Adipose tissue homeostasis depends on interactions between stromal cells, adipocytes, and the cytokines and chemokines they produce. The gp130 cytokine, oncostatin M (OSM), plays a role in adipose tissue homeostasis. Mice, lacking the OSM receptor (OSMR) in adipocytes (OsmrFKO mice), exhibit derangements in adipose tissue, insulin sensitivity, and immune cell balance. Here, we describe a possible role for the chemokine stromal-derived factor 1 (SDF-1) in these alterations. We treated 3T3-L1 adipocytes with OSM and observed a suppression of SDF-1 gene expression and protein secretion, an effect which was partially blunted by OSMR knockdown. However, OsmrFKO mice also exhibited decreased SDF-1 gene and protein expression in adipose tissue. These contrasting results suggest that the loss of adipocyte OSM⁻OSMR signaling in vivo may be indirectly affecting adipokine production and secretion by altering OSM target genes to ultimately decrease SDF-1 expression in the OsmrFKO mouse. We conclude that adipocyte OSM⁻OSMR signaling plays a role in adipose tissue SDF-1 production and may mitigate its effects on adipose tissue homeostasis." @default.
• W2924157074 created "2019-04-01" @default.
• W2924157074 creator A5001823468 @default.
• W2924157074 creator A5009073100 @default.
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• W2924157074 date "2019-03-23" @default.
• W2924157074 modified "2023-10-14" @default.
• W2924157074 title "Oncostatin M Mediates Adipocyte Expression and Secretion of Stromal-Derived Factor 1" @default.
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• W2924157074 doi "https://doi.org/10.3390/biology8010019" @default.
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• W2924157074 hasPublicationYear "2019" @default.
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