FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924346474> ?p ?o ?g. }

• W2924346474 abstract "The blinding inflammatory lesion stromal keratitis (SK), which occurs in some patients in response to ocular herpes simplex virus (HSV) infection, represents mainly an immune cell mediated inflammatory response to the virus infection. The principal orchestrators of the immunopathological lesions are T cells although additional events participate that include the extent of recruitment of non-lymphoid cells, the extent of neoangiogenesis and the extent of damage to nerve function. This review focusses on evidence that the balance of the functional subsets of T cells has a major impact on lesion severity and duration. Accordingly, if proinflammatory Th1 and Th17 CD4 T cells, and perhaps in some cases CD8 T cells, predominate lesions occur earlier and are more severe. Lesions are diminished when cells with regulatory function predominate. Moreover, when regulatory cells acquire the property to produce Amphiregulin this may facilitate lesion resolution. An objective to controlling lesions is to learn how to manipulate the balance of T cells to favor the representation and function of regulatory T cells and their products over proinflammatory cells. In this review we emphasize how exploiting the differential metabolic requirements of immune cells could be a valuable approach to control SK." @default.
• W2924346474 created "2019-04-01" @default.
• W2924346474 creator A5013287504 @default.
• W2924346474 creator A5055852389 @default.
• W2924346474 date "2019-03-19" @default.
• W2924346474 modified "2023-09-25" @default.
• W2924346474 title "The Role of T Cells in Herpes Stromal Keratitis" @default.
• W2924346474 cites W128240883 @default.
• W2924346474 cites W1488739114 @default.
• W2924346474 cites W1546655223 @default.
• W2924346474 cites W1553817667 @default.
• W2924346474 cites W1566416470 @default.
• W2924346474 cites W1605851537 @default.
• W2924346474 cites W1607189030 @default.
• W2924346474 cites W1643523773 @default.
• W2924346474 cites W1743570032 @default.
• W2924346474 cites W1966478716 @default.
• W2924346474 cites W1966972158 @default.
• W2924346474 cites W1972673579 @default.
• W2924346474 cites W1973599173 @default.
• W2924346474 cites W1979126484 @default.
• W2924346474 cites W1982180094 @default.
• W2924346474 cites W1986868882 @default.
• W2924346474 cites W1989516288 @default.
• W2924346474 cites W1995305578 @default.
• W2924346474 cites W1995796039 @default.
• W2924346474 cites W2001051250 @default.
• W2924346474 cites W2006065705 @default.
• W2924346474 cites W2008058658 @default.
• W2924346474 cites W2013010265 @default.
• W2924346474 cites W2016827757 @default.
• W2924346474 cites W2021805498 @default.
• W2924346474 cites W2022816420 @default.
• W2924346474 cites W2024490058 @default.
• W2924346474 cites W2033193447 @default.
• W2924346474 cites W2035208392 @default.
• W2924346474 cites W2036383793 @default.
• W2924346474 cites W2043774001 @default.
• W2924346474 cites W2047509815 @default.
• W2924346474 cites W2060185417 @default.
• W2924346474 cites W2062520454 @default.
• W2924346474 cites W2066675802 @default.
• W2924346474 cites W2071638524 @default.
• W2924346474 cites W2074632761 @default.
• W2924346474 cites W2076327296 @default.
• W2924346474 cites W2083733536 @default.
• W2924346474 cites W2086539844 @default.
• W2924346474 cites W2088910660 @default.
• W2924346474 cites W2095840406 @default.
• W2924346474 cites W2100837670 @default.
• W2924346474 cites W2109492494 @default.
• W2924346474 cites W2118578510 @default.
• W2924346474 cites W2121438737 @default.
• W2924346474 cites W2121672225 @default.
• W2924346474 cites W2121977118 @default.
• W2924346474 cites W2125904103 @default.
• W2924346474 cites W2128587735 @default.
• W2924346474 cites W2132306808 @default.
• W2924346474 cites W2133305239 @default.
• W2924346474 cites W2136341627 @default.
• W2924346474 cites W2137186878 @default.
• W2924346474 cites W2141501395 @default.
• W2924346474 cites W2141649011 @default.
• W2924346474 cites W2145134285 @default.
• W2924346474 cites W2148241125 @default.
• W2924346474 cites W2149477225 @default.
• W2924346474 cites W2152642587 @default.
• W2924346474 cites W2153389047 @default.
• W2924346474 cites W2157739158 @default.
• W2924346474 cites W2275245978 @default.
• W2924346474 cites W2301131921 @default.
• W2924346474 cites W2320226321 @default.
• W2924346474 cites W2340430279 @default.
• W2924346474 cites W2409598223 @default.
• W2924346474 cites W2468925656 @default.
• W2924346474 cites W2487091400 @default.
• W2924346474 cites W2575603832 @default.
• W2924346474 cites W2580505043 @default.
• W2924346474 cites W2735838422 @default.
• W2924346474 cites W2740829994 @default.
• W2924346474 cites W2765319000 @default.
• W2924346474 cites W2783436545 @default.
• W2924346474 cites W2803777243 @default.
• W2924346474 cites W2886922970 @default.
• W2924346474 cites W2902849407 @default.
• W2924346474 cites W2904235927 @default.
• W2924346474 cites W4211052952 @default.
• W2924346474 cites W4320801375 @default.
• W2924346474 doi "https://doi.org/10.3389/fimmu.2019.00512" @default.
• W2924346474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6433787" @default.
• W2924346474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30941142" @default.
• W2924346474 hasPublicationYear "2019" @default.
• W2924346474 type Work @default.
• W2924346474 sameAs 2924346474 @default.
• W2924346474 citedByCount "29" @default.
• W2924346474 countsByYear W29243464742019 @default.
• W2924346474 countsByYear W29243464742020 @default.
• W2924346474 countsByYear W29243464742021 @default.
• W2924346474 countsByYear W29243464742022 @default.
• W2924346474 countsByYear W29243464742023 @default.

• next