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- W2924358404 abstract "Rituximab is a chimeric monoclonal antibody that binds to CD20 antigen of B-cells. It depletes the level of mature B-cells by various mechanisms such as mediation of antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and B-cell apoptosis. Rituximab is a USFDA approved drug for clinical use in non-Hodgkin's B-cell lymphoma (NHL), rheumatoid arthritis, chronic lymphocytic leukemia (CLL), granulomatosis with polyangiitis and pemphigus vulgaris. It is also known for its off label use in renal disease and renal transplant worldwide. However, the exact mechanisms by which it exerts its effect in the aforementioned condition remain unclear but may be related to its long-term effects on plasma cell development and the impact on B-cell modulation of T cell responses. This review discusses the current use of rituximab in renal disease and renal transplantation, and its potential role in novel therapeutic protocols." @default.
- W2924358404 created "2019-04-01" @default.
- W2924358404 creator A5014276245 @default.
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- W2924358404 date "2019-03-26" @default.
- W2924358404 modified "2023-10-17" @default.
- W2924358404 title "Rituximab in kidney disease and transplant" @default.
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- W2924358404 doi "https://doi.org/10.1002/ame2.12064" @default.
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