FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924409326> ?p ?o ?g. }

• W2924409326 abstract "Abstract Accurate histological classification and identification of fusion genes represent two cornerstones of clinical diagnostics in non-small cell lung cancer (NSCLC). Here, we present a NanoString gene expression platform and a novel platform-independent, single sample predictor (SSP) of NSCLC histology for combined, simultaneous, histological classification and fusion gene detection in minimal formalin fixed paraffin embedded (FFPE) tissue. The SSP was developed in 68 NSCLC tumors of adenocarcinoma (AC), squamous cell carcinoma (SqCC) and large-cell neuroendocrine carcinoma (LCNEC) histology, based on NanoString expression of 11 ( CHGA , SYP , CD56 , SFTPG , NAPSA , TTF-1 , TP73L , KRT6A , KRT5 , KRT40 , KRT16 ) relevant genes for IHC-based NSCLC histology classification. The SSP was combined with a gene fusion detection module (analyzing ALK , RET , ROS1 , MET , NRG1 , and NTRK1 ) into a multicomponent NanoString assay. The histological SSP was validated in six cohorts varying in size (n = 11–199), tissue origin (early or advanced disease), histological composition (including undifferentiated cancer), and gene expression platform. Fusion gene detection revealed five EML4-ALK fusions, four KIF5B-RET fusions, two CD74-NRG1 fusion and three MET exon 14 skipping events among 131 tested cases. The histological SSP was successfully trained and tested in the development cohort (mean AUC = 0.96 in iterated test sets). The SSP proved successful in predicting histology of NSCLC tumors of well-defined subgroups and difficult undifferentiated morphology irrespective of gene expression data platform. Discrepancies between gene expression prediction and histologic diagnosis included cases with mixed histologies, true large cell carcinomas, or poorly differentiated adenocarcinomas with mucin expression. In summary, we present a proof-of-concept multicomponent assay for parallel histological classification and multiplexed fusion gene detection in archival tissue, including a novel platform-independent histological SSP classifier. The assay and SSP could serve as a promising complement in the routine evaluation of diagnostic lung cancer biopsies." @default.
• W2924409326 created "2019-04-01" @default.
• W2924409326 creator A5002955183 @default.
• W2924409326 creator A5002992871 @default.
• W2924409326 creator A5028733130 @default.
• W2924409326 creator A5032102375 @default.
• W2924409326 creator A5042394311 @default.
• W2924409326 creator A5043761831 @default.
• W2924409326 creator A5044764887 @default.
• W2924409326 creator A5051144449 @default.
• W2924409326 creator A5051370807 @default.
• W2924409326 creator A5052033876 @default.
• W2924409326 creator A5053093921 @default.
• W2924409326 creator A5056172056 @default.
• W2924409326 creator A5057506311 @default.
• W2924409326 creator A5058658281 @default.
• W2924409326 creator A5074008032 @default.
• W2924409326 creator A5074164236 @default.
• W2924409326 creator A5074514816 @default.
• W2924409326 creator A5074754519 @default.
• W2924409326 creator A5082180772 @default.
• W2924409326 creator A5088103868 @default.
• W2924409326 date "2019-03-26" @default.
• W2924409326 modified "2023-10-16" @default.
• W2924409326 title "A combined gene expression tool for parallel histological prediction and gene fusion detection in non-small cell lung cancer" @default.
• W2924409326 cites W1504251112 @default.
• W2924409326 cites W1809114427 @default.
• W2924409326 cites W1893007615 @default.
• W2924409326 cites W1971369221 @default.
• W2924409326 cites W1985496063 @default.
• W2924409326 cites W2007776026 @default.
• W2924409326 cites W2010770530 @default.
• W2924409326 cites W2035435676 @default.
• W2924409326 cites W2049949128 @default.
• W2924409326 cites W2055402151 @default.
• W2924409326 cites W2091596054 @default.
• W2924409326 cites W2106057638 @default.
• W2924409326 cites W2107296273 @default.
• W2924409326 cites W2108814287 @default.
• W2924409326 cites W2121284021 @default.
• W2924409326 cites W2126640368 @default.
• W2924409326 cites W2156728903 @default.
• W2924409326 cites W2157168213 @default.
• W2924409326 cites W2163523622 @default.
• W2924409326 cites W2169624569 @default.
• W2924409326 cites W2171528238 @default.
• W2924409326 cites W2219924891 @default.
• W2924409326 cites W2251438188 @default.
• W2924409326 cites W2280957887 @default.
• W2924409326 cites W2468271545 @default.
• W2924409326 cites W2473039878 @default.
• W2924409326 cites W2516744702 @default.
• W2924409326 cites W2590398102 @default.
• W2924409326 cites W2596372264 @default.
• W2924409326 cites W2609024728 @default.
• W2924409326 cites W2614866089 @default.
• W2924409326 cites W2738006884 @default.
• W2924409326 cites W2767917908 @default.
• W2924409326 cites W2802791300 @default.
• W2924409326 doi "https://doi.org/10.1038/s41598-019-41585-4" @default.
• W2924409326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6435686" @default.
• W2924409326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30914778" @default.
• W2924409326 hasPublicationYear "2019" @default.
• W2924409326 type Work @default.
• W2924409326 sameAs 2924409326 @default.
• W2924409326 citedByCount "17" @default.
• W2924409326 countsByYear W29244093262020 @default.
• W2924409326 countsByYear W29244093262021 @default.
• W2924409326 countsByYear W29244093262022 @default.
• W2924409326 countsByYear W29244093262023 @default.
• W2924409326 crossrefType "journal-article" @default.
• W2924409326 hasAuthorship W2924409326A5002955183 @default.
• W2924409326 hasAuthorship W2924409326A5002992871 @default.
• W2924409326 hasAuthorship W2924409326A5028733130 @default.
• W2924409326 hasAuthorship W2924409326A5032102375 @default.
• W2924409326 hasAuthorship W2924409326A5042394311 @default.
• W2924409326 hasAuthorship W2924409326A5043761831 @default.
• W2924409326 hasAuthorship W2924409326A5044764887 @default.
• W2924409326 hasAuthorship W2924409326A5051144449 @default.
• W2924409326 hasAuthorship W2924409326A5051370807 @default.
• W2924409326 hasAuthorship W2924409326A5052033876 @default.
• W2924409326 hasAuthorship W2924409326A5053093921 @default.
• W2924409326 hasAuthorship W2924409326A5056172056 @default.
• W2924409326 hasAuthorship W2924409326A5057506311 @default.
• W2924409326 hasAuthorship W2924409326A5058658281 @default.
• W2924409326 hasAuthorship W2924409326A5074008032 @default.
• W2924409326 hasAuthorship W2924409326A5074164236 @default.
• W2924409326 hasAuthorship W2924409326A5074514816 @default.
• W2924409326 hasAuthorship W2924409326A5074754519 @default.
• W2924409326 hasAuthorship W2924409326A5082180772 @default.
• W2924409326 hasAuthorship W2924409326A5088103868 @default.
• W2924409326 hasBestOaLocation W29244093261 @default.
• W2924409326 hasConcept C104317684 @default.
• W2924409326 hasConcept C111829193 @default.
• W2924409326 hasConcept C121608353 @default.
• W2924409326 hasConcept C126322002 @default.
• W2924409326 hasConcept C142724271 @default.
• W2924409326 hasConcept C204232928 @default.
• W2924409326 hasConcept C2776256026 @default.
• W2924409326 hasConcept C2781182431 @default.

• next