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- W2924451352 startingPage "1706" @default.
- W2924451352 abstract "Synaptic terminals grow and retract throughout life, yet synaptic strength is maintained within stable physiological ranges. To study this process, we investigated Drosophila endophilin (endo) mutants. Although active zone (AZ) number is doubled in endo mutants, a compensatory reduction in their size homeostatically adjusts global neurotransmitter output to maintain synaptic strength. We find an inverse adaptation in rab3 mutants. Additional analyses using confocal, STED, and electron microscopy reveal a stoichiometric tuning of AZ scaffolds and nanoarchitecture. Axonal transport of synaptic cargo via the lysosomal kinesin adapter Arl8 regulates AZ abundance to modulate global synaptic output and sustain the homeostatic potentiation of neurotransmission. Finally, we find that this AZ scaling can interface with two independent homeostats, depression and potentiation, to remodel AZ structure and function, demonstrating a robust balancing of separate homeostatic adaptations. Thus, AZs are pliable substrates with elastic and modular nanostructures that can be dynamically sculpted to stabilize and tune both local and global synaptic strength." @default.
- W2924451352 created "2019-04-01" @default.
- W2924451352 creator A5018228978 @default.
- W2924451352 creator A5033144971 @default.
- W2924451352 creator A5047265098 @default.
- W2924451352 creator A5067495401 @default.
- W2924451352 creator A5068664764 @default.
- W2924451352 creator A5070144887 @default.
- W2924451352 creator A5076328677 @default.
- W2924451352 creator A5076965328 @default.
- W2924451352 creator A5085517212 @default.
- W2924451352 date "2019-03-26" @default.
- W2924451352 modified "2023-09-30" @default.
- W2924451352 title "Homeostatic scaling of active zone scaffolds maintains global synaptic strength" @default.
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