FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924494779> ?p ?o ?g. }

• W2924494779 abstract "Summary Ubiquitin and ubiquitin-like chains are finely balanced by the action of conjugating and de-conjugating enzymes. Alterations in this balance trigger signalling events required for the response to stress conditions and are often observed in pathologies. How such changes are detected is not well-understood. We show that upon DNA damage the induction of the de-NEDDylating enzyme NEDP1 restricts the formation of poly-NEDD8 chains, mainly through lysines K11/K48. This promotes APAF1 oligomerisation and apoptosis induction, a step that requires the HSP70 ATPase activity. We found that HSP70 binds to NEDD8 and in vitro , mono-NEDD8 stimulates the ATPase activity of HSP70, counteracted upon poly-NEDDylation. This effect is independent of NEDD8 conjugation onto substrates. The studies identify the HSP70 chaperone as sensor of changes in the NEDD8 cycle, providing mechanistic insights for a cytoplasmic role of NEDD8 in the DNA damage induced apoptosis. They also indicate that the balance between mono- versus poly-NEDDylation is a regulatory module of HSP70 function. The above findings may be important in tumorigenesis, as we find that NEDP1 levels are downregulated in Hepatocellular Carcinoma with concomitant accumulation of NEDD8 conjugates." @default.
• W2924494779 created "2019-04-01" @default.
• W2924494779 creator A5007933365 @default.
• W2924494779 creator A5016331154 @default.
• W2924494779 creator A5021105937 @default.
• W2924494779 creator A5024718667 @default.
• W2924494779 creator A5036874399 @default.
• W2924494779 creator A5077996724 @default.
• W2924494779 creator A5081780580 @default.
• W2924494779 creator A5082030051 @default.
• W2924494779 creator A5088037590 @default.
• W2924494779 date "2019-03-22" @default.
• W2924494779 modified "2023-09-25" @default.
• W2924494779 title "The NEDD8 cycle controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity" @default.
• W2924494779 cites W1482509014 @default.
• W2924494779 cites W1515506492 @default.
• W2924494779 cites W1598608016 @default.
• W2924494779 cites W188992472 @default.
• W2924494779 cites W1964652518 @default.
• W2924494779 cites W1965414705 @default.
• W2924494779 cites W1967960279 @default.
• W2924494779 cites W1972005136 @default.
• W2924494779 cites W1976041483 @default.
• W2924494779 cites W1976685504 @default.
• W2924494779 cites W1983028272 @default.
• W2924494779 cites W1987211450 @default.
• W2924494779 cites W1987277177 @default.
• W2924494779 cites W1995295362 @default.
• W2924494779 cites W1997387127 @default.
• W2924494779 cites W1999268424 @default.
• W2924494779 cites W2001381163 @default.
• W2924494779 cites W2001569984 @default.
• W2924494779 cites W2020357295 @default.
• W2924494779 cites W2021029501 @default.
• W2924494779 cites W2023889729 @default.
• W2924494779 cites W2044347239 @default.
• W2924494779 cites W2050259175 @default.
• W2924494779 cites W2054806801 @default.
• W2924494779 cites W2058901070 @default.
• W2924494779 cites W2061184183 @default.
• W2924494779 cites W2063017603 @default.
• W2924494779 cites W2064878094 @default.
• W2924494779 cites W2065761104 @default.
• W2924494779 cites W2066745745 @default.
• W2924494779 cites W2068518836 @default.
• W2924494779 cites W2075352602 @default.
• W2924494779 cites W2076614723 @default.
• W2924494779 cites W2078495108 @default.
• W2924494779 cites W2085184384 @default.
• W2924494779 cites W2086424573 @default.
• W2924494779 cites W2100581111 @default.
• W2924494779 cites W2107789276 @default.
• W2924494779 cites W2109936231 @default.
• W2924494779 cites W2110548370 @default.
• W2924494779 cites W2118084489 @default.
• W2924494779 cites W2134872883 @default.
• W2924494779 cites W2140321845 @default.
• W2924494779 cites W2141261653 @default.
• W2924494779 cites W2145195328 @default.
• W2924494779 cites W2159565935 @default.
• W2924494779 cites W2160411656 @default.
• W2924494779 cites W2161523490 @default.
• W2924494779 cites W2168588242 @default.
• W2924494779 cites W2610197482 @default.
• W2924494779 cites W2747219203 @default.
• W2924494779 cites W2811242128 @default.
• W2924494779 cites W2915475451 @default.
• W2924494779 doi "https://doi.org/10.1101/583864" @default.
• W2924494779 hasPublicationYear "2019" @default.
• W2924494779 type Work @default.
• W2924494779 sameAs 2924494779 @default.
• W2924494779 citedByCount "0" @default.
• W2924494779 crossrefType "posted-content" @default.
• W2924494779 hasAuthorship W2924494779A5007933365 @default.
• W2924494779 hasAuthorship W2924494779A5016331154 @default.
• W2924494779 hasAuthorship W2924494779A5021105937 @default.
• W2924494779 hasAuthorship W2924494779A5024718667 @default.
• W2924494779 hasAuthorship W2924494779A5036874399 @default.
• W2924494779 hasAuthorship W2924494779A5077996724 @default.
• W2924494779 hasAuthorship W2924494779A5081780580 @default.
• W2924494779 hasAuthorship W2924494779A5082030051 @default.
• W2924494779 hasAuthorship W2924494779A5088037590 @default.
• W2924494779 hasBestOaLocation W29244947791 @default.
• W2924494779 hasConcept C104317684 @default.
• W2924494779 hasConcept C134459356 @default.
• W2924494779 hasConcept C142724271 @default.
• W2924494779 hasConcept C143425029 @default.
• W2924494779 hasConcept C181199279 @default.
• W2924494779 hasConcept C185592680 @default.
• W2924494779 hasConcept C205260736 @default.
• W2924494779 hasConcept C23265538 @default.
• W2924494779 hasConcept C25602115 @default.
• W2924494779 hasConcept C2775962898 @default.
• W2924494779 hasConcept C2779231659 @default.
• W2924494779 hasConcept C45005369 @default.
• W2924494779 hasConcept C552990157 @default.
• W2924494779 hasConcept C55493867 @default.
• W2924494779 hasConcept C68991219 @default.
• W2924494779 hasConcept C71924100 @default.
• W2924494779 hasConcept C86803240 @default.

• next