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• W2924528028 abstract "Abstract Voltage-gated sodium channels (VGSC) are transmembrane proteins that generate an action potential in excitable cells and play an essential role in neuronal signaling. Since VGSCs play a crucial role in nerve transmission they have become primary targets for a broad range of commercial insecticides. RNA interference (RNAi) is a valuable reverse genetics tool used in functional genomics, but recently, it has also shown promise as a novel agent that could be used to control agricultural insect pests. In this study, we targeted the VGSC ( MpNa v ) gene in the peach-potato aphid Myzus persicae , by oral feeding of artificial diets mixed with dsRNAs. Knock-down of MpNa v gene expression caused up to 65% mortality in 3 rd instar nymphs. Moreover, significantly lower fecundity and longevity was observed in adult aphids that had been fed with dsMpNa v solution at the nymphal stage. Analysis of gene expression by qRT-PCR indicated that the aphid mortality rates and the lowered fecundity and longevity were attributable to the down-regulation of MpNa v by RNAi. Taken together, our results show that MpNa v is a viable candidate target gene for the development of an RNAi-based bio-aphicide." @default.
• W2924528028 created "2019-04-01" @default.
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• W2924528028 date "2019-03-28" @default.
• W2924528028 modified "2023-10-16" @default.
• W2924528028 title "RNA interference-mediated knockdown of voltage-gated sodium channel (MpNav) gene causes mortality in peach-potato aphid, Myzus persicae" @default.
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• W2924528028 doi "https://doi.org/10.1038/s41598-019-41832-8" @default.
• W2924528028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6439219" @default.
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• W2924528028 hasPublicationYear "2019" @default.
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