Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924549202> ?p ?o ?g. }
- W2924549202 endingPage "1903" @default.
- W2924549202 startingPage "1894" @default.
- W2924549202 abstract "To identify the transporters involved in renal elimination of relebactam, and to assess the potential of relebactam as a perpetrator or victim of drug−drug interactions (DDIs) for major drug transporters. A series of bidirectional transport, uptake and inhibition studies were conducted in vitro using transfected cell lines and membrane vesicles. The inhibitory effects of relebactam on major drug transporters, as well as the inhibitory effects of commonly used antibiotics/antifungals on organic anion transporter (OAT) 3-mediated uptake of relebactam, were assessed. Relebactam was shown to be a substrate of OAT3, OAT4, and multidrug and toxin extrusion (MATE) proteins MATE1 and MATE2K. Relebactam did not show profound inhibition across a panel of transporters, including organic anion-transporting polypeptides 1B1 and 1B3, OAT1, OAT3, organic cation transporter 2, MATE1, MATE2K, breast cancer resistance protein, multidrug resistance protein 1 and the bile salt export pump. Among the antibiotics/antifungals assessed for potential DDIs, probenecid demonstrated the most potent in vitro inhibition of relebactam uptake; however, such in vitro data did not translate into clinically relevant DDIs, suggesting that relebactam can be co-administered with OAT inhibitors, such as probenecid. Overall, relebactam has low potential to be a victim or perpetrator of DDIs with major drug transporters." @default.
- W2924549202 created "2019-04-01" @default.
- W2924549202 creator A5012642289 @default.
- W2924549202 creator A5015714594 @default.
- W2924549202 creator A5064305769 @default.
- W2924549202 creator A5066264337 @default.
- W2924549202 creator A5081371600 @default.
- W2924549202 creator A5082048814 @default.
- W2924549202 creator A5082359884 @default.
- W2924549202 date "2019-03-19" @default.
- W2924549202 modified "2023-09-24" @default.
- W2924549202 title "Role of transporters in the disposition of a novel β-lactamase inhibitor: relebactam (MK-7655)" @default.
- W2924549202 cites W1508816133 @default.
- W2924549202 cites W1850703972 @default.
- W2924549202 cites W1889656319 @default.
- W2924549202 cites W1916323032 @default.
- W2924549202 cites W1927939563 @default.
- W2924549202 cites W1967930591 @default.
- W2924549202 cites W1977024456 @default.
- W2924549202 cites W1979307648 @default.
- W2924549202 cites W1987857738 @default.
- W2924549202 cites W1990524769 @default.
- W2924549202 cites W1996669107 @default.
- W2924549202 cites W2004612922 @default.
- W2924549202 cites W2011560794 @default.
- W2924549202 cites W2013411037 @default.
- W2924549202 cites W2022246037 @default.
- W2924549202 cites W2025894603 @default.
- W2924549202 cites W2044906812 @default.
- W2924549202 cites W2050540577 @default.
- W2924549202 cites W2062176677 @default.
- W2924549202 cites W2064278251 @default.
- W2924549202 cites W2067808501 @default.
- W2924549202 cites W2072188970 @default.
- W2924549202 cites W2081213990 @default.
- W2924549202 cites W2082627462 @default.
- W2924549202 cites W2089429110 @default.
- W2924549202 cites W2102006967 @default.
- W2924549202 cites W2103323995 @default.
- W2924549202 cites W2108985755 @default.
- W2924549202 cites W2116320617 @default.
- W2924549202 cites W2121515108 @default.
- W2924549202 cites W2122764045 @default.
- W2924549202 cites W2125337025 @default.
- W2924549202 cites W2128736157 @default.
- W2924549202 cites W2134789996 @default.
- W2924549202 cites W2139911027 @default.
- W2924549202 cites W2144143337 @default.
- W2924549202 cites W2145451520 @default.
- W2924549202 cites W2148368238 @default.
- W2924549202 cites W2155512096 @default.
- W2924549202 cites W2158870082 @default.
- W2924549202 cites W2168749478 @default.
- W2924549202 cites W2169592887 @default.
- W2924549202 cites W2171070365 @default.
- W2924549202 cites W2505961383 @default.
- W2924549202 cites W2518662404 @default.
- W2924549202 cites W2573036173 @default.
- W2924549202 cites W2593347693 @default.
- W2924549202 doi "https://doi.org/10.1093/jac/dkz101" @default.
- W2924549202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30891606" @default.
- W2924549202 hasPublicationYear "2019" @default.
- W2924549202 type Work @default.
- W2924549202 sameAs 2924549202 @default.
- W2924549202 citedByCount "11" @default.
- W2924549202 countsByYear W29245492022019 @default.
- W2924549202 countsByYear W29245492022020 @default.
- W2924549202 countsByYear W29245492022021 @default.
- W2924549202 countsByYear W29245492022022 @default.
- W2924549202 crossrefType "journal-article" @default.
- W2924549202 hasAuthorship W2924549202A5012642289 @default.
- W2924549202 hasAuthorship W2924549202A5015714594 @default.
- W2924549202 hasAuthorship W2924549202A5064305769 @default.
- W2924549202 hasAuthorship W2924549202A5066264337 @default.
- W2924549202 hasAuthorship W2924549202A5081371600 @default.
- W2924549202 hasAuthorship W2924549202A5082048814 @default.
- W2924549202 hasAuthorship W2924549202A5082359884 @default.
- W2924549202 hasConcept C104317684 @default.
- W2924549202 hasConcept C123584848 @default.
- W2924549202 hasConcept C133936738 @default.
- W2924549202 hasConcept C149011108 @default.
- W2924549202 hasConcept C185592680 @default.
- W2924549202 hasConcept C200082930 @default.
- W2924549202 hasConcept C202751555 @default.
- W2924549202 hasConcept C2776769776 @default.
- W2924549202 hasConcept C2780035454 @default.
- W2924549202 hasConcept C2910769707 @default.
- W2924549202 hasConcept C44312359 @default.
- W2924549202 hasConcept C501593827 @default.
- W2924549202 hasConcept C55493867 @default.
- W2924549202 hasConcept C86803240 @default.
- W2924549202 hasConcept C98274493 @default.
- W2924549202 hasConceptScore W2924549202C104317684 @default.
- W2924549202 hasConceptScore W2924549202C123584848 @default.
- W2924549202 hasConceptScore W2924549202C133936738 @default.
- W2924549202 hasConceptScore W2924549202C149011108 @default.
- W2924549202 hasConceptScore W2924549202C185592680 @default.
- W2924549202 hasConceptScore W2924549202C200082930 @default.