FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924555954> ?p ?o ?g. }

• W2924555954 endingPage "1952" @default.
• W2924555954 startingPage "1938" @default.
• W2924555954 abstract "Repetitive visual stimulation profoundly changes sensory processing in the primary visual cortex (V1). We show how the associated adaptive changes are linked to an altered flow of synaptic activation across the V1 laminar microcircuit. Using repeated visual stimulation, we recorded layer-specific responses in V1 of two fixating monkeys. We found that repetition-related spiking suppression was most pronounced outside granular V1 layers that receive the main retinogeniculate input. This repetition-related response suppression was robust to alternating stimuli between the eyes, in line with the notion that repetition-related adaptation is predominantly of cortical origin. Most importantly, current source density (CSD) analysis, which provides an estimate of local net depolarization, revealed that synaptic processing during repeated stimulation was most profoundly affected within supragranular layers, which harbor the bulk of cortico-cortical connections. Direct comparison of the temporal evolution of laminar CSD and spiking activity showed that stimulus repetition first affected supragranular synaptic currents, which translated into a reduction of stimulus-evoked spiking across layers. Together, these results suggest that repetition induces an altered state of intracortical processing that underpins visual adaptation. NEW & NOTEWORTHY Our survival depends on our brains rapidly adapting to ever changing environments. A well-studied form of adaptation occurs whenever we encounter the same or similar stimuli repeatedly. We show that this repetition-related adaptation is supported by systematic changes in the flow of sensory activation across the laminar cortical microcircuitry of primary visual cortex. These results demonstrate how adaptation impacts neuronal interactions across cortical circuits." @default.
• W2924555954 created "2019-04-01" @default.
• W2924555954 creator A5040252856 @default.
• W2924555954 creator A5049346717 @default.
• W2924555954 creator A5071802849 @default.
• W2924555954 creator A5083195125 @default.
• W2924555954 date "2019-05-01" @default.
• W2924555954 modified "2023-10-17" @default.
• W2924555954 title "V1 microcircuit dynamics: altered signal propagation suggests intracortical origins for adaptation in response to visual repetition" @default.
• W2924555954 cites W1521633888 @default.
• W2924555954 cites W1565561704 @default.
• W2924555954 cites W1807438930 @default.
• W2924555954 cites W1831238016 @default.
• W2924555954 cites W1873383122 @default.
• W2924555954 cites W1927932324 @default.
• W2924555954 cites W1935489410 @default.
• W2924555954 cites W1966342514 @default.
• W2924555954 cites W1969456163 @default.
• W2924555954 cites W1973850726 @default.
• W2924555954 cites W1975018267 @default.
• W2924555954 cites W1984647925 @default.
• W2924555954 cites W1986014504 @default.
• W2924555954 cites W1993532945 @default.
• W2924555954 cites W1999333255 @default.
• W2924555954 cites W2000650167 @default.
• W2924555954 cites W2007225590 @default.
• W2924555954 cites W2015944398 @default.
• W2924555954 cites W2021058416 @default.
• W2924555954 cites W2028071797 @default.
• W2924555954 cites W2028310026 @default.
• W2924555954 cites W2030755560 @default.
• W2924555954 cites W2033660305 @default.
• W2924555954 cites W2037593266 @default.
• W2924555954 cites W2042775785 @default.
• W2924555954 cites W2042777876 @default.
• W2924555954 cites W2043864930 @default.
• W2924555954 cites W2046881010 @default.
• W2924555954 cites W2047431989 @default.
• W2924555954 cites W2047990541 @default.
• W2924555954 cites W2050506578 @default.
• W2924555954 cites W2051537466 @default.
• W2924555954 cites W2053315601 @default.
• W2924555954 cites W2054341944 @default.
• W2924555954 cites W2057191104 @default.
• W2924555954 cites W2067702957 @default.
• W2924555954 cites W2071727010 @default.
• W2924555954 cites W2079982717 @default.
• W2924555954 cites W2087173000 @default.
• W2924555954 cites W2088646672 @default.
• W2924555954 cites W2089263332 @default.
• W2924555954 cites W2092871243 @default.
• W2924555954 cites W2094850439 @default.
• W2924555954 cites W2097099483 @default.
• W2924555954 cites W2098580305 @default.
• W2924555954 cites W2109596819 @default.
• W2924555954 cites W2111177605 @default.
• W2924555954 cites W2111736228 @default.
• W2924555954 cites W2118468989 @default.
• W2924555954 cites W2119122949 @default.
• W2924555954 cites W2120079537 @default.
• W2924555954 cites W2124669342 @default.
• W2924555954 cites W2125777593 @default.
• W2924555954 cites W2126730158 @default.
• W2924555954 cites W2127648064 @default.
• W2924555954 cites W2136647172 @default.
• W2924555954 cites W2140555726 @default.
• W2924555954 cites W2143051737 @default.
• W2924555954 cites W2143072133 @default.
• W2924555954 cites W2144530246 @default.
• W2924555954 cites W2146224128 @default.
• W2924555954 cites W2152120108 @default.
• W2924555954 cites W2152744976 @default.
• W2924555954 cites W2155744172 @default.
• W2924555954 cites W2158128048 @default.
• W2924555954 cites W2158866673 @default.
• W2924555954 cites W2159198041 @default.
• W2924555954 cites W2168202614 @default.
• W2924555954 cites W2207105567 @default.
• W2924555954 cites W2237150516 @default.
• W2924555954 cites W2266468563 @default.
• W2924555954 cites W2267038514 @default.
• W2924555954 cites W2279931900 @default.
• W2924555954 cites W2290185842 @default.
• W2924555954 cites W2304766319 @default.
• W2924555954 cites W2321905775 @default.
• W2924555954 cites W2342093171 @default.
• W2924555954 cites W2510872579 @default.
• W2924555954 cites W2513914902 @default.
• W2924555954 cites W2527545736 @default.
• W2924555954 cites W2564407496 @default.
• W2924555954 cites W2568921893 @default.
• W2924555954 cites W2586305175 @default.
• W2924555954 cites W2600225728 @default.
• W2924555954 cites W2770068125 @default.
• W2924555954 cites W2784079369 @default.
• W2924555954 cites W2952206935 @default.
• W2924555954 cites W2980931803 @default.
• W2924555954 doi "https://doi.org/10.1152/jn.00113.2019" @default.

• next