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- W2924577278 abstract "The nature and underlying mechanisms of the observed increased vulnerability to post-traumatic stress disorder (PTSD) in women are unclear. We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of 3,577 European American women (966 PTSD cases and 2,611 trauma-exposed controls). We applied a high-resolution polygenic score approach and Mendelian randomization analysis to investigate genetic correlations and causal relationships. We observed an inverse association of PTSD with genetically determined anthropometric traits related to body shape, independent of body mass index (BMI). The top association was related to BMI-adjusted waist circumference (WCadj; R = -0.079, P < 0.001, Q = 0.011). We estimated a relative decrease of 64.6% (95% CI, 27.5 to 82.7) in the risk of PTSD per 1-SD increase in WCadj. MR-Egger regression analysis showed no evidence of pleiotropic effects in this association (P for pleiotropy = 0.979). We also observed associations of genetically determined WCadj with age at first sexual intercourse and number of sexual partners (P = 0.013 and P < 0.001, respectively). There is a putative causal relationship between genetically determined female body shape and PTSD, which could be mediated by evolutionary mechanisms involved in human sexual behaviors." @default.
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- W2924577278 date "2019-01-01" @default.
- W2924577278 modified "2023-09-23" @default.
- W2924577278 title "A Putative Causal Relationship Between Genetically Determined Female Body Shape And Post-Traumatic Stress Disorder" @default.
- W2924577278 doi "https://doi.org/10.1016/j.euroneuro.2017.06.094" @default.
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