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• W2924582644 abstract "Ageing is defined as the gradual decline of normal physiological functions in a time-dependent manner. Significant progress has been made in characterising the regulatory processes involved in the mechanisms of ageing which would have been hindered without the use of model organisms. Use of alternative model organisms greatly diversifies our understanding of different factors underpinning the ageing process and the potential translation for human application. Unique characteristics make Daphnia an attractive model organism for research into mechanisms underlying ageing, such as transparent body, short generation time, well-characterised methylome, regenerative capabilities and available naturally occurring ecotypes. Most interestingly, genetically identical female and male Daphnia have evolved different average lifespans, providing a unique opportunity for understanding the underlying mechanisms of ageing and regulation of lifespan. Investigating sex differences in longevity could provide insight into principal mechanisms of ageing and lifespan regulation. In this study we provide evidence in support of establishing genetically identical female and male Daphnia as unique and valuable resources for research into mechanisms of ageing and begin to delineate the mechanisms involved in sex differences in lifespan. We identify significant differences between genders in physiological markers such as lifespan, growth rate, heart rate and swimming speed in addition to molecular markers such as lipid peroxidation product accumulation, thiol content decline and age-dependent decline in DNA damage repair efficiency. Overall, our data indicates that investigating sex differences in longevity in the clonal organism Daphnia under controlled laboratory conditions can provide insight into principal mechanisms of ageing and lifespan regulation." @default.
• W2924582644 created "2019-04-01" @default.
• W2924582644 creator A5016967754 @default.
• W2924582644 creator A5026605437 @default.
• W2924582644 creator A5070469250 @default.
• W2924582644 date "2019-07-01" @default.
• W2924582644 modified "2023-09-23" @default.
• W2924582644 title "Ageing differently: Sex-dependent ageing rates in Daphnia magna" @default.
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• W2924582644 doi "https://doi.org/10.1016/j.exger.2019.03.008" @default.
• W2924582644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30922945" @default.
• W2924582644 hasPublicationYear "2019" @default.
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