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- W2924587316 abstract "Microneedle fabrication using biopolymers has emerged as a potential technique to offer additional advantages of biodegradability and enhanced biocompatibility over other polymers. Collagen, a biopolymeric source of extracellular support in human skin, serves the purpose of adaptation and synthesis of dissolvable microneedles as well. Hence the present study is designed to synthesize dissolvable collagen microneedles using micro-molding technique whereas Taguchi analysis was employed to evaluate their correlations and conclude the outcomes as stabilized conditions to produce uniform microneedles. The drug loading and releasing potential of microneedles were demonstrated using trypan blue as a model drug. Moreover, in vitro penetration of fabricated microneedles was conducted on mice skin and histological imaging witnessed its practical potential. This collagen based dissolving microneedles may serve as the promising device for delivering collagen as well as other drugs for the betterment of skin and other health issues respectively, in no time." @default.
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- W2924587316 date "2019-08-01" @default.
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- W2924587316 title "Kinetics of collagen microneedle drug delivery system" @default.
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- W2924587316 doi "https://doi.org/10.1016/j.jddst.2019.03.007" @default.
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