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- W2924615078 abstract "Abstract Anxiety is an emotion that is crucial to an individual's survival strategy. Inter-individual variation of anxiety perception may in extreme cases lead to pathological states that are categorized within the spectrum of anxiety disorders (AD). The examination of anxiety parameters in population based samples may contribute to further understand the genetic underpinnings of anxiety states and disorders and personality traits connected to anxiety. We have recruited a sample of 2659 healthy individuals, all of whom were screened for the absence of any AD and who are well described concerning their psychological state with special focus on anxiety, stress and stress coping, fear, life history and environmental risk factors. In addition, several endophenotypes of AD have been determined for all individuals. We will present phenotype genotype associations within this sample in a genome wide association study including gene environment interactions and the generation of polygenic risk scores. The focus will be on our results of anxiety sensitivity which has been assessed by use of the ASI (Reiss et al., 1986)." @default.
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- W2924615078 date "2019-01-01" @default.
- W2924615078 modified "2023-10-18" @default.
- W2924615078 title "A Genome-Wide Association Study of Anxiety In A German Population Based Sample" @default.
- W2924615078 doi "https://doi.org/10.1016/j.euroneuro.2017.06.142" @default.
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