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- W292462361 abstract "目的筛查中国恒河猴Mamu-A^＊01基因，比较中国恒河猴和印度恒河猴的Mamu-A^＊01基因序列和功能是否相同。方法PCR方法检测128只中国恒河猴，用特异性引物扩增Mamu-A^＊01基因，将PCR扩增后的产物克隆测序后与印度恒河猴的Mamu-A^＊01基因进行同源比对；酶联免疫斑点检测（EHSPOT）方法分别检测5只Mamu-A^＊01基因阳性和5只阴性恒河猴针对SIV、SHIV抗原肽p11C的特异性CTL反应。结果共筛查出5只Mamu-A^＊01基因阳性恒河猴（3．91％），经测序分析后与印度恒河猴的同源性可达99．1％。这5只均为SIV／SHIV感染恒河猴，其中四只SIV感染的猴的EHSPOT结果显示针对p11C的高频CTL反应，斑点数在500—1400/10^6 PBMCs之间，而另1只SHIV感染的恒河猴及5只阴性猴没有斑点出现。结论中国恒河猴含有Mamu-A^＊01基因，基因频率有区域性差异，中国恒河猴的Mamu-A^＊01可提呈特异性抗原肽p11C。" @default.
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- W292462361 date "2008-01-01" @default.
- W292462361 modified "2023-09-24" @default.
- W292462361 title "中国恒河猴Mamu-A^＊01基因筛查及其对抗原肽p11C的特异性CTL反应" @default.
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