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- W2924632206 abstract "Background: Primary hyperparathyroidism (PHPT) has a variable clinicalpresentation and symptomatic PHPT is still the predominant form of thedisease in India. Data from western India is lacking. Aim : To presentthe clinical profile of PHPT from western India. Settings and Design :This retrospective study was conducted at a tertiary care referralcenter. Materials and Methods : We analyzed the clinical presentation,biochemical, radiological features, and operative findings in adultpatients with PHPT (1986-2008) and compared with our published data ofchildren and adolescent patients with PHPT. Statistical Analysis : wasdone with SPSS 16 software. Results : Seventy-nine patients (F: M-2:1)with age ranging from 21 to 55 years (mean 33.5±8.82) wereanalyzed. Skeletal manifestations (75.5%), renal calculi (40.5%) andproximal muscle weakness (45.5%) were the most common symptoms ofpresentation with mean duration of symptoms being 33.70 (median: 24,range 1-120) months. Biochemical features included hypercalcemia (totalcorrected calcium 12.55±1.77 mg/dl), low inorganic phosphorus(1.81±0.682 mg/dl), elevated total alkaline phosphatase (mean:762.2; median: 559; range: 50-4930IU/L) and high parathyroid hormone(PTH) (mean±SD: 866.61±799.15; median: 639.5; range: 52-3820pg/ml). Preoperative localization was achieved in 74 patients andsingle adenoma was found during surgery in 72 patients. Hungry bonedisease was seen in 30.3% and transient hypoparathyroidism developed in62% patients. In comparison to PHPT in children there were nosignificant differences with regard to clinical, laboratory andradiological features. Conclusions : PHPT in western India issymptomatic disorder with skeletal and renal mani-festations at a muchyounger age. Clinical profile of PHPT in children is similar to that ofadults." @default.
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- W2924632206 date "2010-12-31" @default.
- W2924632206 modified "2023-09-27" @default.
- W2924632206 title "Clinical profile of primary hyperparathyroidism from western India: Asingle center experience" @default.
- W2924632206 hasPublicationYear "2010" @default.
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