Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924705691> ?p ?o ?g. }
- W2924705691 endingPage "88" @default.
- W2924705691 startingPage "81" @default.
- W2924705691 abstract "Air pollution is the main urban-related environmental hazard and one of the major contributors to the global burden of disease based on its cardiovascular-respiratory impacts. In children, exposure to urban air pollution is associated, among others, with decelerated neurodevelopment early in life and increased risk of neurodevelopmental problems such as attention-deficit hyperactivity disorder, autism spectrum disorders, academic failure and the start of Alzheimer's pathogenesis. However, the evidence of the effects of air pollution on brain development is still inadequate, mainly due to the limitations in (a) characterizing brain development (most studies were based on subjective tools such as questionnaires or neuropsychological tests) and (b) air pollution exposure (most studies only used residential levels based on geographical modelling and also overlooking the variation in the mixture of air pollutants as well as the composition and hence toxicity of particulate pollutants in different settings), (c) the lack of studies during the most vulnerable stages of brain development (foetal and early life (first two years post-natally)) and (d) the lack of structural and functional imaging data underlying these effects. In mice, in utero exposure to fine particles was linked to structural brain changes and there is a need to establish the generalizability of these findings in human beings. Though scarce, current evidence in children supports the importance of the pre-natal period as a susceptible window of exposure. Two studies in schoolchildren found that pre-natal air pollution exposure might damage brain structure while exposure during childhood was not linked to any structural alteration. Another study showed that children with higher traffic-related air pollution at school had lower functional integration in key brain networks, but no changes in brain structure, possibly partly because of the time window of air pollution exposure (in utero versus childhood exposure). A key development is to discover the windows of greatest sensitivity of structural brain changes to air pollution exposure by incorporating the recent advances in non-invasive imaging to characterize natal and post-natal brain development and exploring whether and to what extend placental dysfunction could mediate such an association. Studying pre-natal life is important because effects at this time are of a potentially irreversible nature and because the largest preventive opportunities occur during these periods." @default.
- W2924705691 created "2019-04-01" @default.
- W2924705691 creator A5002894473 @default.
- W2924705691 creator A5046359435 @default.
- W2924705691 date "2019-04-10" @default.
- W2924705691 modified "2023-10-05" @default.
- W2924705691 title "Pre‐natal brain development as a target for urban air pollution" @default.
- W2924705691 cites W1136542869 @default.
- W2924705691 cites W1209451894 @default.
- W2924705691 cites W1594102900 @default.
- W2924705691 cites W1752651658 @default.
- W2924705691 cites W1828742533 @default.
- W2924705691 cites W1933516342 @default.
- W2924705691 cites W1974386770 @default.
- W2924705691 cites W1979101530 @default.
- W2924705691 cites W1981496519 @default.
- W2924705691 cites W1983030849 @default.
- W2924705691 cites W1984559864 @default.
- W2924705691 cites W1987824576 @default.
- W2924705691 cites W1995727875 @default.
- W2924705691 cites W1997172059 @default.
- W2924705691 cites W2042394746 @default.
- W2924705691 cites W2043709629 @default.
- W2924705691 cites W2047324580 @default.
- W2924705691 cites W2052635085 @default.
- W2924705691 cites W2084673373 @default.
- W2924705691 cites W2085153618 @default.
- W2924705691 cites W2091442256 @default.
- W2924705691 cites W2102923534 @default.
- W2924705691 cites W2113081633 @default.
- W2924705691 cites W2116322149 @default.
- W2924705691 cites W2117738566 @default.
- W2924705691 cites W2128903550 @default.
- W2924705691 cites W2130831435 @default.
- W2924705691 cites W2133862271 @default.
- W2924705691 cites W2135646975 @default.
- W2924705691 cites W2140581099 @default.
- W2924705691 cites W2152739465 @default.
- W2924705691 cites W2162823223 @default.
- W2924705691 cites W2168816058 @default.
- W2924705691 cites W2173451380 @default.
- W2924705691 cites W2186214466 @default.
- W2924705691 cites W2203181040 @default.
- W2924705691 cites W2266796279 @default.
- W2924705691 cites W2286090902 @default.
- W2924705691 cites W2290277226 @default.
- W2924705691 cites W2319339135 @default.
- W2924705691 cites W2326368503 @default.
- W2924705691 cites W2339204296 @default.
- W2924705691 cites W2339543277 @default.
- W2924705691 cites W2473798414 @default.
- W2924705691 cites W2497879403 @default.
- W2924705691 cites W2499884006 @default.
- W2924705691 cites W2510576856 @default.
- W2924705691 cites W2511433639 @default.
- W2924705691 cites W2512520014 @default.
- W2924705691 cites W2521122281 @default.
- W2924705691 cites W2522738868 @default.
- W2924705691 cites W2524545577 @default.
- W2924705691 cites W2565311030 @default.
- W2924705691 cites W2570808694 @default.
- W2924705691 cites W2589232582 @default.
- W2924705691 cites W2607350314 @default.
- W2924705691 cites W2609730754 @default.
- W2924705691 cites W2611917744 @default.
- W2924705691 cites W2622398952 @default.
- W2924705691 cites W2790092182 @default.
- W2924705691 cites W2792100562 @default.
- W2924705691 cites W2793482394 @default.
- W2924705691 cites W4237742659 @default.
- W2924705691 doi "https://doi.org/10.1111/bcpt.13226" @default.
- W2924705691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30884144" @default.
- W2924705691 hasPublicationYear "2019" @default.
- W2924705691 type Work @default.
- W2924705691 sameAs 2924705691 @default.
- W2924705691 citedByCount "40" @default.
- W2924705691 countsByYear W29247056912019 @default.
- W2924705691 countsByYear W29247056912020 @default.
- W2924705691 countsByYear W29247056912021 @default.
- W2924705691 countsByYear W29247056912022 @default.
- W2924705691 countsByYear W29247056912023 @default.
- W2924705691 crossrefType "journal-article" @default.
- W2924705691 hasAuthorship W2924705691A5002894473 @default.
- W2924705691 hasAuthorship W2924705691A5046359435 @default.
- W2924705691 hasBestOaLocation W29247056911 @default.
- W2924705691 hasConcept C118552586 @default.
- W2924705691 hasConcept C14216870 @default.
- W2924705691 hasConcept C15744967 @default.
- W2924705691 hasConcept C169760540 @default.
- W2924705691 hasConcept C169900460 @default.
- W2924705691 hasConcept C18903297 @default.
- W2924705691 hasConcept C201052633 @default.
- W2924705691 hasConcept C2781458332 @default.
- W2924705691 hasConcept C2984223407 @default.
- W2924705691 hasConcept C521259446 @default.
- W2924705691 hasConcept C559116025 @default.
- W2924705691 hasConcept C71924100 @default.
- W2924705691 hasConcept C86803240 @default.