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• W2924745419 endingPage "3045" @default.
• W2924745419 startingPage "3028" @default.
• W2924745419 abstract "Abstract We have previously shown that total knockout of fibroblast growth factor‐2 (FGF‐2) results in prolonged survival and improved motor performance in superoxide dismutase 1 (SOD1 G93A ) mutant mice, the most widely used animal model of the fatal adult onset motor neuron disease amyotrophic lateral sclerosis (ALS). Moreover, we found differential expression of growth factors in SOD1 G93A mice, with distinct regulation patterns of FGF‐2 in spinal cord and muscle tissue. Within the present study we aimed to characterize FGF‐2‐isoform specific effects on survival, motor performance as well as gene expression patterns predominantly in muscle tissue by generating double mutant SOD1 G93A FGF‐2 high molecular weight‐ and SOD1 G93A FGF‐2 low molecular weight‐knockout mice. While isoform specific depletion was not beneficial regarding survival or motor performance of double mutant mice, we found isoform‐dependent differential gene expression of epidermal growth factor (EGF) in the muscle of SOD1 G93A FGF‐2 low molecular weight knockout mice compared to single mutant SOD1 G93A mice. This significant downregulation of EGF in the muscle tissue of double mutant SOD1 G93A FGF‐2 low molecular weight knockout mice implies that FGF‐2 low molecular weight knockout (or the presence of the FGF‐2 high molecular weight isoform) selectively impacts EGF gene expression in ALS muscle tissue." @default.
• W2924745419 created "2019-04-01" @default.
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• W2924745419 date "2019-04-08" @default.
• W2924745419 modified "2023-10-16" @default.
• W2924745419 title "Isoform‐selective as opposed to complete depletion of fibroblast growth factor 2 (FGF‐2) has no major impact on survival and gene expression in SOD1 G93A amyotrophic lateral sclerosis mice" @default.
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• W2924745419 doi "https://doi.org/10.1111/ejn.14405" @default.
• W2924745419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30883949" @default.
• W2924745419 hasPublicationYear "2019" @default.
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