FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924776977> ?p ?o ?g. }

• W2924776977 endingPage "2661" @default.
• W2924776977 startingPage "2649" @default.
• W2924776977 abstract "Abstract Histone modifications, largely regulated by histone acetyltransferases (HAT) and histone deacetylases, have been recognized as major regulatory mechanisms governing human diseases, including cancer. Despite significant effort and recent advances, the mechanism by which the HAT and transcriptional coactivator p300 mediates tumorigenesis remains unclear. Here, we use a genetic and chemical approach to identify the microphthalmia-associated transcription factor (MITF) as a critical downstream target of p300 driving human melanoma growth. Direct transcriptional control of MITF by p300-dependent histone acetylation within proximal gene regulatory regions was coupled to cellular proliferation, suggesting a significant growth regulatory axis. Further analysis revealed forkhead box M1 (FOXM1) as a key effector of the p300–MITF axis driving cell growth that is selectively activated in human melanomas. Targeted chemical inhibition of p300 acetyltransferase activity using a potent and selective catalytic p300/CBP inhibitor demonstrated significant growth inhibitory effects in melanoma cells expressing high levels of MITF. Collectively, these data confirm the critical role of the p300–MITF–FOXM1 axis in melanoma and support p300 as a promising novel epigenetic therapeutic target in human melanoma. Significance: These results show that MITF is a major downstream target of p300 in human melanoma whose expression is predictive of melanoma response to small-molecule inhibition of p300 HAT activity." @default.
• W2924776977 created "2019-04-01" @default.
• W2924776977 creator A5008802134 @default.
• W2924776977 creator A5011240484 @default.
• W2924776977 creator A5011567661 @default.
• W2924776977 creator A5018061374 @default.
• W2924776977 creator A5021297776 @default.
• W2924776977 creator A5039470453 @default.
• W2924776977 creator A5050607613 @default.
• W2924776977 creator A5059061843 @default.
• W2924776977 creator A5062980852 @default.
• W2924776977 creator A5063330136 @default.
• W2924776977 creator A5074565884 @default.
• W2924776977 creator A5086885588 @default.
• W2924776977 date "2019-05-15" @default.
• W2924776977 modified "2023-09-26" @default.
• W2924776977 title "MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma" @default.
• W2924776977 cites W1139788413 @default.
• W2924776977 cites W1590243782 @default.
• W2924776977 cites W1818189828 @default.
• W2924776977 cites W1834835434 @default.
• W2924776977 cites W1953890763 @default.
• W2924776977 cites W1963652662 @default.
• W2924776977 cites W1966467063 @default.
• W2924776977 cites W1977936916 @default.
• W2924776977 cites W1982635732 @default.
• W2924776977 cites W1985928174 @default.
• W2924776977 cites W1990636453 @default.
• W2924776977 cites W1997889534 @default.
• W2924776977 cites W2000146676 @default.
• W2924776977 cites W2003402062 @default.
• W2924776977 cites W2015009944 @default.
• W2924776977 cites W2023613648 @default.
• W2924776977 cites W2031875849 @default.
• W2924776977 cites W2033708806 @default.
• W2924776977 cites W2038838903 @default.
• W2924776977 cites W2052005627 @default.
• W2924776977 cites W2052677817 @default.
• W2924776977 cites W2068261932 @default.
• W2924776977 cites W2074974517 @default.
• W2924776977 cites W2077560715 @default.
• W2924776977 cites W2078370873 @default.
• W2924776977 cites W2082641730 @default.
• W2924776977 cites W2092376103 @default.
• W2924776977 cites W2094998522 @default.
• W2924776977 cites W2104503053 @default.
• W2924776977 cites W2104697581 @default.
• W2924776977 cites W2105516543 @default.
• W2924776977 cites W2110466396 @default.
• W2924776977 cites W2114843025 @default.
• W2924776977 cites W2120490928 @default.
• W2924776977 cites W2121545342 @default.
• W2924776977 cites W2132141505 @default.
• W2924776977 cites W2132630169 @default.
• W2924776977 cites W2133608451 @default.
• W2924776977 cites W2144634936 @default.
• W2924776977 cites W2149441684 @default.
• W2924776977 cites W2156150950 @default.
• W2924776977 cites W2158074192 @default.
• W2924776977 cites W2158416296 @default.
• W2924776977 cites W2159220884 @default.
• W2924776977 cites W2159299286 @default.
• W2924776977 cites W2162497387 @default.
• W2924776977 cites W2164927488 @default.
• W2924776977 cites W2165057403 @default.
• W2924776977 cites W2167823163 @default.
• W2924776977 cites W2170065082 @default.
• W2924776977 cites W2191834728 @default.
• W2924776977 cites W2297701691 @default.
• W2924776977 cites W2300290254 @default.
• W2924776977 cites W2319190863 @default.
• W2924776977 cites W2332292689 @default.
• W2924776977 cites W2428381774 @default.
• W2924776977 cites W2465117107 @default.
• W2924776977 cites W2592824004 @default.
• W2924776977 cites W2605233023 @default.
• W2924776977 cites W2758743773 @default.
• W2924776977 doi "https://doi.org/10.1158/0008-5472.can-18-2331" @default.
• W2924776977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6522293" @default.
• W2924776977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30910803" @default.
• W2924776977 hasPublicationYear "2019" @default.
• W2924776977 type Work @default.
• W2924776977 sameAs 2924776977 @default.
• W2924776977 citedByCount "32" @default.
• W2924776977 countsByYear W29247769772019 @default.
• W2924776977 countsByYear W29247769772020 @default.
• W2924776977 countsByYear W29247769772021 @default.
• W2924776977 countsByYear W29247769772022 @default.
• W2924776977 countsByYear W29247769772023 @default.
• W2924776977 crossrefType "journal-article" @default.
• W2924776977 hasAuthorship W2924776977A5008802134 @default.
• W2924776977 hasAuthorship W2924776977A5011240484 @default.
• W2924776977 hasAuthorship W2924776977A5011567661 @default.
• W2924776977 hasAuthorship W2924776977A5018061374 @default.
• W2924776977 hasAuthorship W2924776977A5021297776 @default.
• W2924776977 hasAuthorship W2924776977A5039470453 @default.
• W2924776977 hasAuthorship W2924776977A5050607613 @default.
• W2924776977 hasAuthorship W2924776977A5059061843 @default.

• next