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- W2924789905 abstract "<ns4:p><ns4:bold>Background:</ns4:bold>Malaria control heavily relies on insecticide-based interventions against mosquito vectors. However, the increasing spread of insecticide resistance is a major threat. The extent to which such resistance, notably metabolic resistance, influences the development of the<ns4:italic>Plasmodium</ns4:italic>parasite and its impact on overall malaria transmission remains poorly characterized. Here, we investigated whether glutathione S-transferase-based resistance could influence<ns4:italic>Plasmodium falciparum</ns4:italic>development in<ns4:italic>Anopheles funestus</ns4:italic>.</ns4:p><ns4:p><ns4:bold>Methods:</ns4:bold><ns4:italic>Anopheles funestus</ns4:italic>females were infected with<ns4:italic>P. falciparum</ns4:italic>gametocytes and midguts were dissected at day 7 post infection for detection/quantification of oocysts. Infection parameters were compared between individuals with different L119F-GSTe2 genotypes, and the polymorphism of the GSTe2 gene was analyzed in infected and uninfected mosquito groups.</ns4:p><ns4:p><ns4:bold>Results:</ns4:bold>Overall, 403<ns4:italic>An. funestus</ns4:italic> mosquitoes were dissected and genotyped. The frequency of the L119F-GSTe2 resistance allele was significantly higher in non-infected (55.88%) compared to infected (40.99%) mosquitoes (Fisher's exact test, P<0.0001). Prevalence of infection was significantly higher in heterozygous and homozygous susceptible genotypes (P<0.001). However, homozygous resistant and heterozygous mosquitoes exhibited significantly higher infection intensity (P<0.01). No association was observed between the GSTe2 polymorphism and the infection status of mosquitoes.</ns4:p><ns4:p><ns4:bold>Conclusion:</ns4:bold>Altogether, these results suggest that GSTe2-based metabolic resistance may affect the vectorial competence of resistant<ns4:italic>An. funestus</ns4:italic>mosquitoes to<ns4:italic>P. falciparum</ns4:italic>infection, by possibly increasing its permissiveness to<ns4:italic>Plasmodium</ns4:italic>infection.</ns4:p>" @default.
- W2924789905 created "2019-04-01" @default.
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- W2924789905 date "2019-10-11" @default.
- W2924789905 modified "2023-10-18" @default.
- W2924789905 title "Exploring the impact of glutathione S-transferase (GST)-based metabolic resistance to insecticide on vector competence of Anopheles funestus for Plasmodium falciparum" @default.
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- W2924789905 doi "https://doi.org/10.12688/wellcomeopenres.15061.2" @default.
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