Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924804970> ?p ?o ?g. }
- W2924804970 endingPage "270" @default.
- W2924804970 startingPage "270" @default.
- W2924804970 abstract "Recent advances in genomics technology have led to the massive discovery of new drug targets for prostate cancer; however, none of the currently available therapeutics is curative. One of the greatest challenges is drug resistance. Combinations of therapies with distinct mechanisms of action represent a promising strategy that has received renewed attention in recent years. Combination therapies exert cancer killing functions through either concomitant targeting of multiple pro-cancer factors or more effective inhibition of a single pathway. Theoretically, the combination therapy can improve efficacy and efficiency compared with monotherapy. Although increasing numbers of drug combinations are currently being tested in clinical trials, the mechanisms by which these combinations can overcome drug resistance have yet to be fully understood. The purpose of this review is to summarize recent work on therapeutic combinations in the treatment of castration-resistant prostate cancer and discuss emerging mechanisms underlying drug resistance. In addition, we provide an overview of the current preclinical mechanistic studies on potential therapeutic combinations to overcome drug resistance." @default.
- W2924804970 created "2019-04-01" @default.
- W2924804970 creator A5053509821 @default.
- W2924804970 creator A5072668725 @default.
- W2924804970 date "2019-01-01" @default.
- W2924804970 modified "2023-09-25" @default.
- W2924804970 title "Current opinion and mechanistic interpretation of combination therapy for castration-resistant prostate cancer" @default.
- W2924804970 cites W1489963450 @default.
- W2924804970 cites W1582446028 @default.
- W2924804970 cites W1654777185 @default.
- W2924804970 cites W1882606371 @default.
- W2924804970 cites W1964160901 @default.
- W2924804970 cites W1968786809 @default.
- W2924804970 cites W1972182648 @default.
- W2924804970 cites W1977645286 @default.
- W2924804970 cites W1979811833 @default.
- W2924804970 cites W1985051375 @default.
- W2924804970 cites W1992624438 @default.
- W2924804970 cites W2003086854 @default.
- W2924804970 cites W2009607678 @default.
- W2924804970 cites W2010072924 @default.
- W2924804970 cites W2016064098 @default.
- W2924804970 cites W2017839954 @default.
- W2924804970 cites W2017919614 @default.
- W2924804970 cites W2022478555 @default.
- W2924804970 cites W2029325271 @default.
- W2924804970 cites W2031569848 @default.
- W2924804970 cites W2037700362 @default.
- W2924804970 cites W2049481073 @default.
- W2924804970 cites W2053273553 @default.
- W2924804970 cites W2060641409 @default.
- W2924804970 cites W2065016129 @default.
- W2924804970 cites W2074429860 @default.
- W2924804970 cites W2080439368 @default.
- W2924804970 cites W2083981959 @default.
- W2924804970 cites W2084891840 @default.
- W2924804970 cites W2085847636 @default.
- W2924804970 cites W2091266023 @default.
- W2924804970 cites W2092783245 @default.
- W2924804970 cites W2097226696 @default.
- W2924804970 cites W2097694375 @default.
- W2924804970 cites W2103845239 @default.
- W2924804970 cites W2103959341 @default.
- W2924804970 cites W2110534364 @default.
- W2924804970 cites W2110841612 @default.
- W2924804970 cites W2117857186 @default.
- W2924804970 cites W2118428599 @default.
- W2924804970 cites W2118498123 @default.
- W2924804970 cites W2121846636 @default.
- W2924804970 cites W2121863482 @default.
- W2924804970 cites W2123629153 @default.
- W2924804970 cites W2128628205 @default.
- W2924804970 cites W2129509993 @default.
- W2924804970 cites W2130189600 @default.
- W2924804970 cites W2130846254 @default.
- W2924804970 cites W2132441555 @default.
- W2924804970 cites W2143994426 @default.
- W2924804970 cites W2144110960 @default.
- W2924804970 cites W2146898402 @default.
- W2924804970 cites W2149131962 @default.
- W2924804970 cites W2149752186 @default.
- W2924804970 cites W2150865892 @default.
- W2924804970 cites W2156391988 @default.
- W2924804970 cites W2156923287 @default.
- W2924804970 cites W2157046916 @default.
- W2924804970 cites W2157448426 @default.
- W2924804970 cites W2160834915 @default.
- W2924804970 cites W2161112598 @default.
- W2924804970 cites W2161996879 @default.
- W2924804970 cites W2166918329 @default.
- W2924804970 cites W2169258216 @default.
- W2924804970 cites W2178183066 @default.
- W2924804970 cites W2179454156 @default.
- W2924804970 cites W2181283187 @default.
- W2924804970 cites W2235405584 @default.
- W2924804970 cites W2256020981 @default.
- W2924804970 cites W2268281268 @default.
- W2924804970 cites W2284926981 @default.
- W2924804970 cites W2338494814 @default.
- W2924804970 cites W2342931301 @default.
- W2924804970 cites W2344610509 @default.
- W2924804970 cites W2345499901 @default.
- W2924804970 cites W2405684830 @default.
- W2924804970 cites W2463867199 @default.
- W2924804970 cites W2465860350 @default.
- W2924804970 cites W2507307365 @default.
- W2924804970 cites W2509171004 @default.
- W2924804970 cites W2514715990 @default.
- W2924804970 cites W2514821758 @default.
- W2924804970 cites W2528897263 @default.
- W2924804970 cites W2531934133 @default.
- W2924804970 cites W2533072646 @default.
- W2924804970 cites W2560367415 @default.
- W2924804970 cites W2570914061 @default.
- W2924804970 cites W2587048937 @default.
- W2924804970 cites W2589771973 @default.
- W2924804970 cites W2595314544 @default.
- W2924804970 cites W2599194052 @default.