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- W2924863378 endingPage "4946" @default.
- W2924863378 startingPage "4932" @default.
- W2924863378 abstract "Peptides and proteins are two classes of molecules with attractive possibilities for therapeutic applications. However, the bottleneck for the therapeutic application of many peptides and proteins is their short halflives in vivo, typically just a few minutes to hours. Half-life extension strategies have been extensively studied and many of them have been proven to be effective in the generation of long-acting therapeutics with improved pharmacokinetic and pharmacodynamic properties. In this review, we summarize the recent advances in half-life extension strategies, illustrate their potential applications and give some examples, highlighting the strategies that have been used in approved drugs and for drugs in clinical trials. Meanwhile, several novel strategies that are still in the process of discovery or at a preclinical stage are also introduced. In these strategies, the two most frequently used half-life extension methods are the reduction in the rate of renal clearance or the exploitation of the recycling mechanism of FcRn by binding to the albumin or IgG-Fc. Here, we discuss half-life extension strategies of recombinant therapeutic protein via genetic fusion, rather than chemical conjugation such as PEGylation. With the rapid development of genetic engineering and protein engineering, novel strategies for half-life extension have been emerged consistently. Some of these will be evaluated in clinical trials and may become viable alternatives to current strategies for making next-generation biodrugs." @default.
- W2924863378 created "2019-04-01" @default.
- W2924863378 creator A5002726082 @default.
- W2924863378 creator A5042115254 @default.
- W2924863378 creator A5042419038 @default.
- W2924863378 creator A5046686387 @default.
- W2924863378 creator A5085906662 @default.
- W2924863378 creator A5091136369 @default.
- W2924863378 date "2019-03-20" @default.
- W2924863378 modified "2023-10-02" @default.
- W2924863378 title "Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins" @default.
- W2924863378 cites W1478059225 @default.
- W2924863378 cites W1528046172 @default.
- W2924863378 cites W1547437295 @default.
- W2924863378 cites W1848085765 @default.
- W2924863378 cites W1873045526 @default.
- W2924863378 cites W1884460322 @default.
- W2924863378 cites W1964515043 @default.
- W2924863378 cites W1964530118 @default.
- W2924863378 cites W1968606358 @default.
- W2924863378 cites W1969215799 @default.
- W2924863378 cites W1974086743 @default.
- W2924863378 cites W1974965024 @default.
- W2924863378 cites W1975088956 @default.
- W2924863378 cites W1975687628 @default.
- W2924863378 cites W1981273187 @default.
- W2924863378 cites W1983169511 @default.
- W2924863378 cites W1986236572 @default.
- W2924863378 cites W1986482604 @default.
- W2924863378 cites W1988329494 @default.
- W2924863378 cites W1991333616 @default.
- W2924863378 cites W1996719014 @default.
- W2924863378 cites W1997792880 @default.
- W2924863378 cites W1999082606 @default.
- W2924863378 cites W2002757015 @default.
- W2924863378 cites W2005188958 @default.
- W2924863378 cites W2007102329 @default.
- W2924863378 cites W2009624023 @default.
- W2924863378 cites W2010598175 @default.
- W2924863378 cites W2013322454 @default.
- W2924863378 cites W2015811602 @default.
- W2924863378 cites W2020398834 @default.
- W2924863378 cites W2020558940 @default.
- W2924863378 cites W2022246635 @default.
- W2924863378 cites W2022325287 @default.
- W2924863378 cites W2027268124 @default.
- W2924863378 cites W2027894892 @default.
- W2924863378 cites W2029875542 @default.
- W2924863378 cites W2034327086 @default.
- W2924863378 cites W2035737764 @default.
- W2924863378 cites W2035980708 @default.
- W2924863378 cites W2043106306 @default.
- W2924863378 cites W2044526502 @default.
- W2924863378 cites W2044791218 @default.
- W2924863378 cites W2050000500 @default.
- W2924863378 cites W2051933587 @default.
- W2924863378 cites W2054088567 @default.
- W2924863378 cites W2056825212 @default.
- W2924863378 cites W2063330281 @default.
- W2924863378 cites W2064033300 @default.
- W2924863378 cites W2065219066 @default.
- W2924863378 cites W2066680692 @default.
- W2924863378 cites W2069620845 @default.
- W2924863378 cites W2071843728 @default.
- W2924863378 cites W2072150928 @default.
- W2924863378 cites W2073047768 @default.
- W2924863378 cites W2076709027 @default.
- W2924863378 cites W2077787026 @default.
- W2924863378 cites W2078810596 @default.
- W2924863378 cites W2079361682 @default.
- W2924863378 cites W2079996410 @default.
- W2924863378 cites W2080622379 @default.
- W2924863378 cites W2081405125 @default.
- W2924863378 cites W2087865968 @default.
- W2924863378 cites W2088696708 @default.
- W2924863378 cites W2088729407 @default.
- W2924863378 cites W2088867591 @default.
- W2924863378 cites W2089464982 @default.
- W2924863378 cites W2093832010 @default.
- W2924863378 cites W2096547439 @default.
- W2924863378 cites W2099381753 @default.
- W2924863378 cites W2100436247 @default.
- W2924863378 cites W2108049900 @default.
- W2924863378 cites W2111426991 @default.
- W2924863378 cites W2112512464 @default.
- W2924863378 cites W2118100404 @default.
- W2924863378 cites W2118848581 @default.
- W2924863378 cites W2125130429 @default.
- W2924863378 cites W2125311831 @default.
- W2924863378 cites W2127630336 @default.
- W2924863378 cites W2129596910 @default.
- W2924863378 cites W2129967914 @default.
- W2924863378 cites W2131063559 @default.
- W2924863378 cites W2134636215 @default.
- W2924863378 cites W2137780217 @default.
- W2924863378 cites W2138756996 @default.
- W2924863378 cites W2138788677 @default.
- W2924863378 cites W2150417402 @default.