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• W2924877653 abstract "ABSTRACT Epstein-Barr virus (EBV), a herpes virus also termed HHV 4 and the first identified human tumor virus, establishes a stable long-term latent infection in human B cells, its preferred host. Upon induction of EBV’s lytic phase the latently infected cells turn into a virus factory, a process, that is governed by EBV. In the lytic, productive phase all herpesviruses ensure the efficient induction of all lytic viral genes to produce progeny, but certain of these genes also repress the ensuing antiviral responses of the virally infected host cells, regulate their apoptotic death or control the cellular transcriptome. We now find that EBV causes previously unknown massive and global alterations in the chromatin of its host cell upon induction of the viral lytic phase and prior to the onset of viral DNA replication. The viral initiator protein of the lytic cycle, BZLF1, binds to >10 5 binding sites with different sequence motifs in cellular chromatin and in a concentration dependent manner. Concomitant with DNA binding, silent chromatin opens locally as shown by ATAC-seq experiments, while previously wide-open cellular chromatin becomes inaccessible on a global scale within hours. While viral transcripts increase drastically, the induction of the lytic phase results in a massive reduction of cellular transcripts and a loss of chromatin-chromatin interactions of cellular promoters with their distal regulatory elements as shown in Capture-C experiments. Our data document that EBV’s lytic cycle induces discrete early processes that disrupt the architecture of host cellular chromatin and repress the cellular epigenome and transcriptome likely supporting the efficient de novo synthesis of this herpesvirus." @default.
• W2924877653 created "2019-04-01" @default.
• W2924877653 creator A5012760420 @default.
• W2924877653 creator A5028406221 @default.
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• W2924877653 creator A5065977507 @default.
• W2924877653 creator A5069430515 @default.
• W2924877653 creator A5077481610 @default.
• W2924877653 creator A5084721168 @default.
• W2924877653 creator A5084845680 @default.
• W2924877653 creator A5090277402 @default.
• W2924877653 date "2019-03-20" @default.
• W2924877653 modified "2023-09-25" @default.
• W2924877653 title "Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation" @default.
• W2924877653 cites W1514653354 @default.
• W2924877653 cites W1524314531 @default.
• W2924877653 cites W1709815505 @default.
• W2924877653 cites W1776208966 @default.
• W2924877653 cites W1841083068 @default.
• W2924877653 cites W1885323688 @default.
• W2924877653 cites W1899455654 @default.
• W2924877653 cites W1935232254 @default.
• W2924877653 cites W1955814132 @default.
• W2924877653 cites W1963680287 @default.
• W2924877653 cites W1964904043 @default.
• W2924877653 cites W1968839741 @default.
• W2924877653 cites W1970281468 @default.
• W2924877653 cites W1974223852 @default.
• W2924877653 cites W1976788864 @default.
• W2924877653 cites W1978977626 @default.
• W2924877653 cites W1979404155 @default.
• W2924877653 cites W1984820123 @default.
• W2924877653 cites W1985148567 @default.
• W2924877653 cites W1986806711 @default.
• W2924877653 cites W1994219871 @default.
• W2924877653 cites W1995332968 @default.
• W2924877653 cites W2001294950 @default.
• W2924877653 cites W2002707039 @default.
• W2924877653 cites W2003063544 @default.
• W2924877653 cites W2010324176 @default.
• W2924877653 cites W2012897051 @default.
• W2924877653 cites W2015086018 @default.
• W2924877653 cites W2015616819 @default.
• W2924877653 cites W2017086224 @default.
• W2924877653 cites W2018012447 @default.
• W2924877653 cites W2021341670 @default.
• W2924877653 cites W2021743722 @default.
• W2924877653 cites W2027231325 @default.
• W2924877653 cites W2033768471 @default.
• W2924877653 cites W2044296969 @default.
• W2924877653 cites W2045112394 @default.
• W2924877653 cites W2053011150 @default.
• W2924877653 cites W2053982216 @default.
• W2924877653 cites W2054961298 @default.
• W2924877653 cites W2059502471 @default.
• W2924877653 cites W2060262597 @default.
• W2924877653 cites W2062434608 @default.
• W2924877653 cites W2072113006 @default.
• W2924877653 cites W2072319964 @default.
• W2924877653 cites W2077941487 @default.
• W2924877653 cites W2081135713 @default.
• W2924877653 cites W2084737819 @default.
• W2924877653 cites W2085161568 @default.
• W2924877653 cites W2085610443 @default.
• W2924877653 cites W2091695015 @default.
• W2924877653 cites W2093146349 @default.
• W2924877653 cites W2095800987 @default.
• W2924877653 cites W2095844198 @default.
• W2924877653 cites W2095953096 @default.
• W2924877653 cites W2096122705 @default.
• W2924877653 cites W2097105020 @default.
• W2924877653 cites W2097175728 @default.
• W2924877653 cites W2098159895 @default.
• W2924877653 cites W2098692163 @default.
• W2924877653 cites W2102619694 @default.
• W2924877653 cites W2105959269 @default.
• W2924877653 cites W2107088342 @default.
• W2924877653 cites W2108234281 @default.
• W2924877653 cites W2110958455 @default.
• W2924877653 cites W2116109634 @default.
• W2924877653 cites W2117131162 @default.
• W2924877653 cites W2117757143 @default.
• W2924877653 cites W2119535180 @default.
• W2924877653 cites W2123029438 @default.
• W2924877653 cites W2123711411 @default.
• W2924877653 cites W2124985265 @default.
• W2924877653 cites W2127362401 @default.
• W2924877653 cites W2131829335 @default.
• W2924877653 cites W2134104386 @default.
• W2924877653 cites W2134225989 @default.
• W2924877653 cites W2134526812 @default.
• W2924877653 cites W2135644627 @default.
• W2924877653 cites W2138441377 @default.
• W2924877653 cites W2138633314 @default.
• W2924877653 cites W2140729960 @default.
• W2924877653 cites W2141301893 @default.
• W2924877653 cites W2143665924 @default.
• W2924877653 cites W2147979404 @default.
• W2924877653 cites W2148350655 @default.
• W2924877653 cites W2152722520 @default.

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