Matches in SemOpenAlex for { <https://semopenalex.org/work/W2924970350> ?p ?o ?g. }
- W2924970350 endingPage "E939" @default.
- W2924970350 startingPage "E931" @default.
- W2924970350 abstract "The objective of this study is to determine whether AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), or peroxisome proliferator-activated receptor β (PPARβ) can independently mediate the increase of glucose transporter type 4 (GLUT4) expression that occurs in response to exercise training. We found that PPARβ can regulate GLUT4 expression without PGC-1α. We also found AMPK and PPARβ are important for maintaining normal physiological levels of GLUT4 protein in the sedentary condition as well following exercise training. However, AMPK and PPARβ are not essential for the increase in GLUT4 protein expression that occurs in response to exercise training. We discovered that AMPK activation increases PPARβ via myocyte enhancer factor 2A (MEF2A), which acted as a transcription factor for PPARβ. Furthermore, exercise training increases the cooperation of AMPK and PPARβ to regulate glucose uptake. In conclusion, cooperation between AMPK and PPARβ via NRF-1/MEF2A pathway enhances the exercise training mediated adaptive increase in GLUT4 expression and subsequent glucose uptake in skeletal muscle." @default.
- W2924970350 created "2019-04-01" @default.
- W2924970350 creator A5002287349 @default.
- W2924970350 creator A5039592281 @default.
- W2924970350 creator A5040214380 @default.
- W2924970350 creator A5048447364 @default.
- W2924970350 creator A5063618672 @default.
- W2924970350 creator A5064721834 @default.
- W2924970350 date "2019-05-01" @default.
- W2924970350 modified "2023-10-16" @default.
- W2924970350 title "AMPK and PPARβ positive feedback loop regulates endurance exercise training-mediated GLUT4 expression in skeletal muscle" @default.
- W2924970350 cites W1560517084 @default.
- W2924970350 cites W1577804997 @default.
- W2924970350 cites W1775749144 @default.
- W2924970350 cites W1857724021 @default.
- W2924970350 cites W1872744326 @default.
- W2924970350 cites W1955901897 @default.
- W2924970350 cites W1972477005 @default.
- W2924970350 cites W1980435606 @default.
- W2924970350 cites W1988642111 @default.
- W2924970350 cites W1996885736 @default.
- W2924970350 cites W2000884265 @default.
- W2924970350 cites W2034618205 @default.
- W2924970350 cites W2047982128 @default.
- W2924970350 cites W2061075485 @default.
- W2924970350 cites W2062748949 @default.
- W2924970350 cites W2064754499 @default.
- W2924970350 cites W2069037616 @default.
- W2924970350 cites W2071631797 @default.
- W2924970350 cites W2077645437 @default.
- W2924970350 cites W2084321300 @default.
- W2924970350 cites W2090662467 @default.
- W2924970350 cites W2096440265 @default.
- W2924970350 cites W2103856172 @default.
- W2924970350 cites W2104476914 @default.
- W2924970350 cites W2120158532 @default.
- W2924970350 cites W2121031147 @default.
- W2924970350 cites W2125732396 @default.
- W2924970350 cites W2128557965 @default.
- W2924970350 cites W2129266853 @default.
- W2924970350 cites W2140147315 @default.
- W2924970350 cites W2144485530 @default.
- W2924970350 cites W2146283921 @default.
- W2924970350 cites W2152235545 @default.
- W2924970350 cites W2160524748 @default.
- W2924970350 cites W2165038103 @default.
- W2924970350 cites W2168808578 @default.
- W2924970350 cites W2170255149 @default.
- W2924970350 cites W2284504147 @default.
- W2924970350 cites W2611125209 @default.
- W2924970350 doi "https://doi.org/10.1152/ajpendo.00460.2018" @default.
- W2924970350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6580175" @default.
- W2924970350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30888859" @default.
- W2924970350 hasPublicationYear "2019" @default.
- W2924970350 type Work @default.
- W2924970350 sameAs 2924970350 @default.
- W2924970350 citedByCount "24" @default.
- W2924970350 countsByYear W29249703502019 @default.
- W2924970350 countsByYear W29249703502020 @default.
- W2924970350 countsByYear W29249703502021 @default.
- W2924970350 countsByYear W29249703502022 @default.
- W2924970350 crossrefType "journal-article" @default.
- W2924970350 hasAuthorship W2924970350A5002287349 @default.
- W2924970350 hasAuthorship W2924970350A5039592281 @default.
- W2924970350 hasAuthorship W2924970350A5040214380 @default.
- W2924970350 hasAuthorship W2924970350A5048447364 @default.
- W2924970350 hasAuthorship W2924970350A5063618672 @default.
- W2924970350 hasAuthorship W2924970350A5064721834 @default.
- W2924970350 hasBestOaLocation W29249703501 @default.
- W2924970350 hasConcept C104317684 @default.
- W2924970350 hasConcept C126322002 @default.
- W2924970350 hasConcept C134018914 @default.
- W2924970350 hasConcept C161573976 @default.
- W2924970350 hasConcept C170493617 @default.
- W2924970350 hasConcept C184235292 @default.
- W2924970350 hasConcept C185592680 @default.
- W2924970350 hasConcept C187345961 @default.
- W2924970350 hasConcept C2776188179 @default.
- W2924970350 hasConcept C2776780712 @default.
- W2924970350 hasConcept C2777866211 @default.
- W2924970350 hasConcept C2779306644 @default.
- W2924970350 hasConcept C2779959927 @default.
- W2924970350 hasConcept C2780124434 @default.
- W2924970350 hasConcept C55493867 @default.
- W2924970350 hasConcept C71924100 @default.
- W2924970350 hasConcept C77445288 @default.
- W2924970350 hasConcept C86339819 @default.
- W2924970350 hasConcept C86803240 @default.
- W2924970350 hasConcept C95444343 @default.
- W2924970350 hasConcept C97029542 @default.
- W2924970350 hasConceptScore W2924970350C104317684 @default.
- W2924970350 hasConceptScore W2924970350C126322002 @default.
- W2924970350 hasConceptScore W2924970350C134018914 @default.
- W2924970350 hasConceptScore W2924970350C161573976 @default.
- W2924970350 hasConceptScore W2924970350C170493617 @default.
- W2924970350 hasConceptScore W2924970350C184235292 @default.
- W2924970350 hasConceptScore W2924970350C185592680 @default.
- W2924970350 hasConceptScore W2924970350C187345961 @default.