FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2925128375> ?p ?o ?g. }

• W2925128375 endingPage "1240" @default.
• W2925128375 startingPage "1230" @default.
• W2925128375 abstract "MISFOLDED PROTEIN SENSING RING1 (MPSR1) is a chaperone-independent E3 ubiquitin ligase that participates in protein quality control by eliminating misfolded proteins in Arabidopsis (Arabidopsis thaliana). Here, we report that in the early stages of proteotoxic stress, cellular levels of MPSR1 increased immediately, whereas levels of HEAT SHOCK PROTEIN90.1 (AtHSP90.1) were unaltered despite massively upregulated transcription. At this stage, the gene-silencing pathway mediated by microRNA 414 (miR414) suppressed AtHSP90.1 translation. By contrast, under prolonged stress, AtHSP90.1 was not suppressed, and instead competed with MPSR1 to act on misfolded proteins, promoting the destruction of MPSR1. Deficiency or excess of MPSR1 significantly abolished or intensified the suppression of AtHSP90.1, respectively. Similar to the MPSR1-overexpressing transgenic plants, the miR414-overexpressing plants showed an increased tolerance to proteotoxic stress as compared to the wild-type plants. Although the functional relationship between MPSR1 and miR414 remains unclear, both MPSR1 and miR414 demonstrated negative modulation of the expression of AtHSP90.1. The inverse correlation between MPSR1 and AtHSP90.1 via miR414 may adjust the set-point of the HSP90-mediated protein quality control process in response to increasing stress intensity in Arabidopsis." @default.
• W2925128375 created "2019-04-01" @default.
• W2925128375 creator A5009556007 @default.
• W2925128375 creator A5032881372 @default.
• W2925128375 creator A5051879388 @default.
• W2925128375 creator A5069536475 @default.
• W2925128375 creator A5083962703 @default.
• W2925128375 date "2019-03-19" @default.
• W2925128375 modified "2023-10-16" @default.
• W2925128375 title "Inverse Correlation Between MPSR1 E3 Ubiquitin Ligase and HSP90.1 Balances Cytoplasmic Protein Quality Control" @default.
• W2925128375 cites W1754425562 @default.
• W2925128375 cites W1932667901 @default.
• W2925128375 cites W1949609863 @default.
• W2925128375 cites W1963716493 @default.
• W2925128375 cites W1965754110 @default.
• W2925128375 cites W1972999456 @default.
• W2925128375 cites W1981606645 @default.
• W2925128375 cites W1992219896 @default.
• W2925128375 cites W1995677293 @default.
• W2925128375 cites W1998792334 @default.
• W2925128375 cites W2004543547 @default.
• W2925128375 cites W2007455466 @default.
• W2925128375 cites W2010242135 @default.
• W2925128375 cites W2019383594 @default.
• W2925128375 cites W2020584700 @default.
• W2925128375 cites W2021040301 @default.
• W2925128375 cites W2021792489 @default.
• W2925128375 cites W2025902786 @default.
• W2925128375 cites W2029589758 @default.
• W2925128375 cites W2035412505 @default.
• W2925128375 cites W2076704497 @default.
• W2925128375 cites W2082382374 @default.
• W2925128375 cites W2092989899 @default.
• W2925128375 cites W2095283819 @default.
• W2925128375 cites W2099157613 @default.
• W2925128375 cites W2105798984 @default.
• W2925128375 cites W2109936231 @default.
• W2925128375 cites W2113174490 @default.
• W2925128375 cites W2114197574 @default.
• W2925128375 cites W2120453962 @default.
• W2925128375 cites W2120794445 @default.
• W2925128375 cites W2125589734 @default.
• W2925128375 cites W2139632133 @default.
• W2925128375 cites W2140197221 @default.
• W2925128375 cites W2161034934 @default.
• W2925128375 cites W2171260748 @default.
• W2925128375 cites W2265228656 @default.
• W2925128375 cites W2562623982 @default.
• W2925128375 cites W2625598731 @default.
• W2925128375 cites W2687042098 @default.
• W2925128375 cites W2734619127 @default.
• W2925128375 cites W2734814984 @default.
• W2925128375 cites W2745539279 @default.
• W2925128375 cites W2751238998 @default.
• W2925128375 cites W2765429876 @default.
• W2925128375 cites W2766377580 @default.
• W2925128375 cites W2787816332 @default.
• W2925128375 cites W2903022477 @default.
• W2925128375 doi "https://doi.org/10.1104/pp.18.01582" @default.
• W2925128375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6548273" @default.
• W2925128375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30890661" @default.
• W2925128375 hasPublicationYear "2019" @default.
• W2925128375 type Work @default.
• W2925128375 sameAs 2925128375 @default.
• W2925128375 citedByCount "8" @default.
• W2925128375 countsByYear W29251283752020 @default.
• W2925128375 countsByYear W29251283752021 @default.
• W2925128375 countsByYear W29251283752022 @default.
• W2925128375 countsByYear W29251283752023 @default.
• W2925128375 crossrefType "journal-article" @default.
• W2925128375 hasAuthorship W2925128375A5009556007 @default.
• W2925128375 hasAuthorship W2925128375A5032881372 @default.
• W2925128375 hasAuthorship W2925128375A5051879388 @default.
• W2925128375 hasAuthorship W2925128375A5069536475 @default.
• W2925128375 hasAuthorship W2925128375A5083962703 @default.
• W2925128375 hasBestOaLocation W29251283751 @default.
• W2925128375 hasConcept C104317684 @default.
• W2925128375 hasConcept C134459356 @default.
• W2925128375 hasConcept C142724271 @default.
• W2925128375 hasConcept C143065580 @default.
• W2925128375 hasConcept C205260736 @default.
• W2925128375 hasConcept C25602115 @default.
• W2925128375 hasConcept C2775932338 @default.
• W2925128375 hasConcept C2775962898 @default.
• W2925128375 hasConcept C2775988993 @default.
• W2925128375 hasConcept C2779491563 @default.
• W2925128375 hasConcept C2781452922 @default.
• W2925128375 hasConcept C54355233 @default.
• W2925128375 hasConcept C71924100 @default.
• W2925128375 hasConcept C86803240 @default.
• W2925128375 hasConcept C95444343 @default.
• W2925128375 hasConceptScore W2925128375C104317684 @default.
• W2925128375 hasConceptScore W2925128375C134459356 @default.
• W2925128375 hasConceptScore W2925128375C142724271 @default.
• W2925128375 hasConceptScore W2925128375C143065580 @default.
• W2925128375 hasConceptScore W2925128375C205260736 @default.
• W2925128375 hasConceptScore W2925128375C25602115 @default.
• W2925128375 hasConceptScore W2925128375C2775932338 @default.

• next