FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2925169610> ?p ?o ?g. }

• W2925169610 abstract "This study was designed to investigate the hemodynamic effect of rolipram, a phosphodiesterase type 4 (PDE4) inhibitor, in normal rat hearts both in vivo and in vitro and its underlying mechanism. The pressure-volume loop, isolated heart, and Ca2+ transients triggered by field stimulation or caffeine were used to analyze the hemodynamic mechanism of rolipram. The results demonstrated that rolipram (3 mg/kg, ip) significantly increased the in vivo rat heart contractility by enhancing stroke work, cardiac output, stroke volume, end-systolic volume, end-diastolic volume, end-systolic pressure, heart rate, ejection fraction, peak rate of rise of left pressure (+dp/dtmax), the slopes of end-systolic pressure-volume relationship (slope of ESPVR) named as left ventricular end-systolic elastance, and reduced the slopes of end-diastolic pressure-volume relationship (slope of EDPVR). Meanwhile, the systolic blood pressure, diastolic blood pressure, and pulse pressure were significantly enhanced by rolipram. Also, rolipram deviated normal ventricular-arterial coupling without changing the arterial elastance. Furthermore, rolipram (0.1, 1, 10 μM) also exerted positive inotropic effect in isolated rat hearts by increasing the left ventricular development pressure, and +dp/dtmax in non-paced and paced modes. Rolipram (10 μM) increased the SERCA2a activity, Ca2+ content, and Ca2+ leak rate without changing diastolic Ca2+ level. Rolipram had significant positive inotropic effect with less effect on peripheral vascular elastance and its underlying mechanism was mediated by increasing SERCA2a activity. PDE4 inhibition by rolipram resulted in a positive inotropic effect and might serve as a target for developing agents for the treatment of heart failure in clinical settings." @default.
• W2925169610 created "2019-04-01" @default.
• W2925169610 creator A5010787427 @default.
• W2925169610 creator A5012324763 @default.
• W2925169610 creator A5013667077 @default.
• W2925169610 creator A5015941197 @default.
• W2925169610 creator A5020010287 @default.
• W2925169610 creator A5035136216 @default.
• W2925169610 creator A5043197140 @default.
• W2925169610 creator A5051238737 @default.
• W2925169610 creator A5065362776 @default.
• W2925169610 creator A5067534346 @default.
• W2925169610 creator A5067669370 @default.
• W2925169610 date "2019-03-22" @default.
• W2925169610 modified "2023-09-25" @default.
• W2925169610 title "Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a" @default.
• W2925169610 cites W1706609463 @default.
• W2925169610 cites W1972029787 @default.
• W2925169610 cites W1978893552 @default.
• W2925169610 cites W1984733648 @default.
• W2925169610 cites W1986612273 @default.
• W2925169610 cites W1995559527 @default.
• W2925169610 cites W2008221502 @default.
• W2925169610 cites W2015557754 @default.
• W2925169610 cites W2022863579 @default.
• W2925169610 cites W2026716749 @default.
• W2925169610 cites W2046727216 @default.
• W2925169610 cites W2049393400 @default.
• W2925169610 cites W2051464148 @default.
• W2925169610 cites W2054773469 @default.
• W2925169610 cites W2085845988 @default.
• W2925169610 cites W2109640441 @default.
• W2925169610 cites W2116714338 @default.
• W2925169610 cites W2138134399 @default.
• W2925169610 cites W2140379282 @default.
• W2925169610 cites W2161214266 @default.
• W2925169610 cites W2265270202 @default.
• W2925169610 cites W2546095465 @default.
• W2925169610 cites W2588025879 @default.
• W2925169610 cites W2791132131 @default.
• W2925169610 cites W2797381224 @default.
• W2925169610 doi "https://doi.org/10.3389/fphar.2019.00221" @default.
• W2925169610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6439224" @default.
• W2925169610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30967774" @default.
• W2925169610 hasPublicationYear "2019" @default.
• W2925169610 type Work @default.
• W2925169610 sameAs 2925169610 @default.
• W2925169610 citedByCount "9" @default.
• W2925169610 countsByYear W29251696102020 @default.
• W2925169610 countsByYear W29251696102021 @default.
• W2925169610 countsByYear W29251696102022 @default.
• W2925169610 crossrefType "journal-article" @default.
• W2925169610 hasAuthorship W2925169610A5010787427 @default.
• W2925169610 hasAuthorship W2925169610A5012324763 @default.
• W2925169610 hasAuthorship W2925169610A5013667077 @default.
• W2925169610 hasAuthorship W2925169610A5015941197 @default.
• W2925169610 hasAuthorship W2925169610A5020010287 @default.
• W2925169610 hasAuthorship W2925169610A5035136216 @default.
• W2925169610 hasAuthorship W2925169610A5043197140 @default.
• W2925169610 hasAuthorship W2925169610A5051238737 @default.
• W2925169610 hasAuthorship W2925169610A5065362776 @default.
• W2925169610 hasAuthorship W2925169610A5067534346 @default.
• W2925169610 hasAuthorship W2925169610A5067669370 @default.
• W2925169610 hasBestOaLocation W29251696101 @default.
• W2925169610 hasConcept C126322002 @default.
• W2925169610 hasConcept C139940330 @default.
• W2925169610 hasConcept C155710745 @default.
• W2925169610 hasConcept C164705383 @default.
• W2925169610 hasConcept C178853913 @default.
• W2925169610 hasConcept C181199279 @default.
• W2925169610 hasConcept C185592680 @default.
• W2925169610 hasConcept C2776452961 @default.
• W2925169610 hasConcept C2776766087 @default.
• W2925169610 hasConcept C2776958096 @default.
• W2925169610 hasConcept C2777953023 @default.
• W2925169610 hasConcept C39133596 @default.
• W2925169610 hasConcept C55493867 @default.
• W2925169610 hasConcept C62826618 @default.
• W2925169610 hasConcept C71924100 @default.
• W2925169610 hasConcept C80461066 @default.
• W2925169610 hasConcept C84393581 @default.
• W2925169610 hasConceptScore W2925169610C126322002 @default.
• W2925169610 hasConceptScore W2925169610C139940330 @default.
• W2925169610 hasConceptScore W2925169610C155710745 @default.
• W2925169610 hasConceptScore W2925169610C164705383 @default.
• W2925169610 hasConceptScore W2925169610C178853913 @default.
• W2925169610 hasConceptScore W2925169610C181199279 @default.
• W2925169610 hasConceptScore W2925169610C185592680 @default.
• W2925169610 hasConceptScore W2925169610C2776452961 @default.
• W2925169610 hasConceptScore W2925169610C2776766087 @default.
• W2925169610 hasConceptScore W2925169610C2776958096 @default.
• W2925169610 hasConceptScore W2925169610C2777953023 @default.
• W2925169610 hasConceptScore W2925169610C39133596 @default.
• W2925169610 hasConceptScore W2925169610C55493867 @default.
• W2925169610 hasConceptScore W2925169610C62826618 @default.
• W2925169610 hasConceptScore W2925169610C71924100 @default.
• W2925169610 hasConceptScore W2925169610C80461066 @default.
• W2925169610 hasConceptScore W2925169610C84393581 @default.
• W2925169610 hasFunder F4320321001 @default.
• W2925169610 hasLocation W29251696101 @default.

• next