Matches in SemOpenAlex for { <https://semopenalex.org/work/W2925186688> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2925186688 endingPage "124" @default.
- W2925186688 startingPage "117" @default.
- W2925186688 abstract "<b><i>Background:</i></b> We tested the cutaneous distribution of 50 chemicals in frozen human skin. The mass balance (MB) values for 48% of the chemicals were < 90%, possibly due to evaporation. <b><i>Methods:</i></b> We confirmed the reduction in MB was due to evaporation for two chemicals tested in skin penetration experiments using a carbon filter above the skin to trap airborne chemical. An in vitro assay was used to predict the reduction in MB due to evaporation by comparing the recovery of chemicals after 4 h of incubation at room temperature in open and closed vials. <b><i>Results:</i></b> Evaporative losses in vitro correlated well with measured MBs (i.e., < 90%) in skin penetration experiments (<i>R</i><sup>2</sup> = 0.81). There was a correlation of the MB with the vapour pressure (VP) which could be used to group chemicals according to their likelihood to evaporate during the course of a skin penetration study. There was also a correlation of MB with Henry’s law constants, melting and boiling points. <b><i>Conclusion:</i></b> Our data support the use of a quick and simple test for volatility to account for the loss of MB in skin penetration experiment due to volatility. The best parameter to indicate the potential of a chemical to evaporate is the VP." @default.
- W2925186688 created "2019-04-01" @default.
- W2925186688 creator A5004745328 @default.
- W2925186688 creator A5014509954 @default.
- W2925186688 creator A5026959014 @default.
- W2925186688 creator A5030275661 @default.
- W2925186688 creator A5042340703 @default.
- W2925186688 creator A5049971921 @default.
- W2925186688 creator A5059193098 @default.
- W2925186688 creator A5064780645 @default.
- W2925186688 creator A5065039350 @default.
- W2925186688 creator A5074271642 @default.
- W2925186688 creator A5076546186 @default.
- W2925186688 creator A5080829078 @default.
- W2925186688 date "2019-01-01" @default.
- W2925186688 modified "2023-10-15" @default.
- W2925186688 title "Use of a Simple in vitro Test to Assess Loss of Chemical due to Volatility during an in vitro Human Skin Absorption Study" @default.
- W2925186688 cites W1981955059 @default.
- W2925186688 cites W1986104523 @default.
- W2925186688 cites W1987008379 @default.
- W2925186688 cites W2144348215 @default.
- W2925186688 cites W2610861416 @default.
- W2925186688 cites W2736642393 @default.
- W2925186688 doi "https://doi.org/10.1159/000497105" @default.
- W2925186688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30889606" @default.
- W2925186688 hasPublicationYear "2019" @default.
- W2925186688 type Work @default.
- W2925186688 sameAs 2925186688 @default.
- W2925186688 citedByCount "8" @default.
- W2925186688 countsByYear W29251866882019 @default.
- W2925186688 countsByYear W29251866882020 @default.
- W2925186688 countsByYear W29251866882021 @default.
- W2925186688 countsByYear W29251866882022 @default.
- W2925186688 countsByYear W29251866882023 @default.
- W2925186688 crossrefType "journal-article" @default.
- W2925186688 hasAuthorship W2925186688A5004745328 @default.
- W2925186688 hasAuthorship W2925186688A5014509954 @default.
- W2925186688 hasAuthorship W2925186688A5026959014 @default.
- W2925186688 hasAuthorship W2925186688A5030275661 @default.
- W2925186688 hasAuthorship W2925186688A5042340703 @default.
- W2925186688 hasAuthorship W2925186688A5049971921 @default.
- W2925186688 hasAuthorship W2925186688A5059193098 @default.
- W2925186688 hasAuthorship W2925186688A5064780645 @default.
- W2925186688 hasAuthorship W2925186688A5065039350 @default.
- W2925186688 hasAuthorship W2925186688A5074271642 @default.
- W2925186688 hasAuthorship W2925186688A5076546186 @default.
- W2925186688 hasAuthorship W2925186688A5080829078 @default.
- W2925186688 hasConcept C106159729 @default.
- W2925186688 hasConcept C127413603 @default.
- W2925186688 hasConcept C162324750 @default.
- W2925186688 hasConcept C185592680 @default.
- W2925186688 hasConcept C202751555 @default.
- W2925186688 hasConcept C42475967 @default.
- W2925186688 hasConcept C43617362 @default.
- W2925186688 hasConcept C55493867 @default.
- W2925186688 hasConcept C80107235 @default.
- W2925186688 hasConcept C91602232 @default.
- W2925186688 hasConceptScore W2925186688C106159729 @default.
- W2925186688 hasConceptScore W2925186688C127413603 @default.
- W2925186688 hasConceptScore W2925186688C162324750 @default.
- W2925186688 hasConceptScore W2925186688C185592680 @default.
- W2925186688 hasConceptScore W2925186688C202751555 @default.
- W2925186688 hasConceptScore W2925186688C42475967 @default.
- W2925186688 hasConceptScore W2925186688C43617362 @default.
- W2925186688 hasConceptScore W2925186688C55493867 @default.
- W2925186688 hasConceptScore W2925186688C80107235 @default.
- W2925186688 hasConceptScore W2925186688C91602232 @default.
- W2925186688 hasIssue "3" @default.
- W2925186688 hasLocation W29251866881 @default.
- W2925186688 hasLocation W29251866882 @default.
- W2925186688 hasOpenAccess W2925186688 @default.
- W2925186688 hasPrimaryLocation W29251866881 @default.
- W2925186688 hasRelatedWork W2007023362 @default.
- W2925186688 hasRelatedWork W2100738912 @default.
- W2925186688 hasRelatedWork W2119200684 @default.
- W2925186688 hasRelatedWork W2411071714 @default.
- W2925186688 hasRelatedWork W2414267994 @default.
- W2925186688 hasRelatedWork W2432754337 @default.
- W2925186688 hasRelatedWork W2439982970 @default.
- W2925186688 hasRelatedWork W2899084033 @default.
- W2925186688 hasRelatedWork W2948807893 @default.
- W2925186688 hasRelatedWork W2778153218 @default.
- W2925186688 hasVolume "32" @default.
- W2925186688 isParatext "false" @default.
- W2925186688 isRetracted "false" @default.
- W2925186688 magId "2925186688" @default.
- W2925186688 workType "article" @default.